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A case report of inhibition and severe desnutrition: negative symptoms in resistant schizophrenia

Published online by Cambridge University Press:  01 September 2022

P. Coucheiro Limeres*
Affiliation:
Hospital Universitario José Germain, Psychiatry Department, Leganés, Spain
B. Díez Valle
Affiliation:
Hospital Severo Ochoa, Psychiatry, Leganés, Spain
A. Cerame
Affiliation:
Hospital Universitario José Germain, Psychiatry Department, Leganés, Spain
C. Lozano Serrano
Affiliation:
Hospital Universitario José Germain, Psychiatry Department, Leganés, Spain
E. Navas Collado
Affiliation:
Hospital Universitario José Germain, Psychiatry Department, Leganés, Spain
*
*Corresponding author.

Abstract

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Introduction

The appearance of inhibitory symptoms encompassed in what are known as negative symptoms is part of the usual symptoms of schizophrenia. Sometimes this inhibition reaches a significant severity, so it is essential to know its approach.

Objectives

Case report and literature review regarding the treatment of resistant schizophrenia with a predominance of negative symptoms

Methods

We present the clinical case of a 28-year-old man diagnosed with schizophrenia at 23 years old, whose onset was characterized by delusional ideas of harm (poisoning) and delusions with a mystic-religious theme that lead him to reduce his intake until requiring a first admission for severe desnutrition. Subsequently, after two more admissions, the patient presents selective reduction in food intake, decrease in daily activity and apathy without positive symptoms.

Results

Throughout the treatment, several lines of antipsychotic treatments have been tried at the maximum tolerated dose (haloperidol, oral paliperidone and depot, aripiprazole and clozapine up to a dose of 600 mg). Clozapine resistance required testing various augmentation strategies (Venlafaxine, Lamotrigine and Electroconvulsive therapy) with low results. Finally, to complement the treatment, the patient was transferred to a mid-stay unit where psychosocial treatment with a multidisciplinary approach was started. This has allowed more continuous follow-up and thus a partial improvement of the clinic.

Conclusions

Numerous studies describe numerous augmentation strategies for clozapine-resistant schizophrenia with negative symptoms. However, the results are still inconclusive, needing more research. Meanwhile, we want to highlight the importance of complementing the treatment with psychosocial approaches.

Disclosure

No significant relationships.

Type
Abstract
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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