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Brain anatomy of symptom stratification in schizophrenia: A voxel based morphometry study

Published online by Cambridge University Press:  23 March 2020

G. Delvecchio ,
A. Lorandi ,
C. Perilini ,
M. Barillari ,
M. Ruggeri ,
A.C. Altamura ,
M. Bellani  and
P. Brambilla
G. Delvecchio
Affiliation:
IRCCS “E. Medea”, scientific institute, San Vito al Tagliamento, Italy
A. Lorandi
Affiliation:
Azienda Ospedaliera universitaria integrata Verona, section of psychiatry, Verona, Italy
C. Perilini
Affiliation:
Biomedicine and movement sciences, section of clinical psychology, university of Verona, department of neurosciences, Verona, Italy
M. Barillari
Affiliation:
Azienda ospedaliera universitaria integrata Verona, section of radiology, Verona, Italy
M. Ruggeri
Affiliation:
Biomedicine and movement sciences, section of psychiatry, university of Verona, department of neurosciences, Verona, Italy
A.C. Altamura
Affiliation:
Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, university of Milan, department of neurosciences and mental health, Milan, Italy
M. Bellani
Affiliation:
Azienda Ospedaliera universitaria integrata Verona, section of psychiatry, Verona, Italy
P. Brambilla
Affiliation:
Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, university of Milan, department of neurosciences and mental health, Milan, Italy

Abstract

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Introduction

Although some magnetic resonance imaging (MRI) studies have investigated the existence of a relationship between clinical severity and neuroanatomical alterations in patients with schizophrenia (SCZ), the biological signature associated with illness severity in schizophrenia is still uncertain.

Objectives

This study aims to investigate structural brain abnormalities in SCZ with particular regards to the identification of potential deficits associated to the severity of illness.

Methods

1.5 T MRI data were acquired for 61 subjects with SCZ and 59 matched healthy controls (HC). The patient group was divided in two subgroups based on clinical severity, one composed by 34 mild-to-moderately ill patients and the other one by 27 severely ill patients, and compared with matched HC.

Results

The whole group of patients with SCZ had significantly reduced gray matter (GM) volumes in left inferior and middle temporal gyrus compared to HC (P < 0.05, pFWE corrected). Furthermore, compared to HC, patients with mild-to-moderate illness showed decreased GM volumes in inferior temporal gyrus (P < 0.05, pFWE corrected) whereas those with severe illness had reduced right cerebellum (P < 0.05, cFWE corrected). No differences were observed between the two subgroups of patients.

Conclusions

Our results showed significant GM volume reductions in left inferior and middle temporal gyrus in patients with SCZ compared to matched HC, confirming the role of this region in the pathophysiology of SCZ. Furthermore, we identified specific cerebellar gray matter volume reductions in patients with severe illness, which may contribute to stratify patients with SCZ according to their clinical phenotype expression, ultimately helping in guiding targeted therapeutic/rehabilitation interventions.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
e-Poster Walk: Neuroimaging and neuroscience in psychiatry
Information
European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. S345
Copyright
Copyright © European Psychiatric Association 2017
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