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Borderline personality disorder and childhood maltreatment: A genome-wide methylation analysis

Published online by Cambridge University Press:  23 March 2020

L. Stenz ,
J. Prados ,
P. Courtet ,
P. Prada ,
R. Nicastro ,
W. Adouan ,
S. Guillaume ,
E. Olié ,
J.M. Aubry  and
A. Dayer
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L. Stenz*
Affiliation:
SwitzerlandSwitzerland
J. Prados
Affiliation:
Geneva university, departement of psychiatry, Geneva, Switzerland
P. Courtet
Affiliation:
Centre Hospitalier Régional Universitaire de Montpelier, Department of Emergency Psychiatry, Montpellier, France
P. Prada
Affiliation:
University Hospitals of Geneva, Department of Mental Health and Psychiatry, Geneva, Switzerland
R. Nicastro
Affiliation:
University Hospitals of Geneva, Department of Mental Health and Psychiatry, Geneva, Switzerland
W. Adouan
Affiliation:
University of Geneva, Department of Psychiatry, Geneva, Switzerland
S. Guillaume
Affiliation:
Centre Hospitalier Régional Universitaire de Montpelier, Department of Emergency Psychiatry, Montpellier, France
E. Olié
Affiliation:
Centre Hospitalier Régional Universitaire de Montpelier, Department of Emergency Psychiatry, Montpellier, France
J.M. Aubry
Affiliation:
University Hospitals of Geneva, Department of Mental Health and Psychiatry, Geneva, Switzerland
A. Dayer
Affiliation:
Geneva Unviersity, Department of Psychiatry, Geneva, Switzerland
N. Perroud
Affiliation:
University Hospitals of Geneva, Department of Mental Health and Psychiatry, Geneva, Switzerland
*
*Corresponding author.

Abstract

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Early life adversity plays a critical role in the emergence of borderline personality disorder (BPD) and this could occur through epigenetic programming. In this perspective, we aimed to determine whether childhood maltreatment could durably modify epigenetic processes by the means of a whole-genome methylation scan of BPD subjects. Using the Illumina Infinium® Human Methylation 450 Bead Chip, global methylation status of DNA extracted from peripheral blood leucocytes was correlated to the severity of childhood maltreatment in 96 BPD subjects suffering from a high level of child adversity and 93 subjects suffering from major depressive disorder (MDD) and reporting a low rate of child maltreatment. Several CpGs within or near the following genes (IL17RA, miR124-3, KCNQ2, EFNB1, OCA2, MFAP2, RPH3AL, WDR60, CST9L, EP400, A2ML1, NT5DC2, FAM163A and SPSB2) were found to be differently methylated, either in BPD compared with MDD or in relation to the severity of childhood maltreatment. A highly relevant biological result was observed for cg04927004 close to miR124-3 that was significantly associated with BPD and severity of childhood maltreatment. miR124-3 codes for a microRNA (miRNA) targeting several genes previously found to be associated with BPD such as NR3C1. Our results highlight the potentially important role played by miRNAs in the etiology of neuropsychiatric disorders such as BPD and the usefulness of using methylome-wide association studies to uncover such candidate genes. Moreover, they offer new understanding of the impact of maltreatments on biological processes leading to diseases and may ultimately result in the identification of relevant biomarkers.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
EW282
Information
European Psychiatry , Volume 33 , Issue S1: Abstracts of the 24th European Congress of Psychiatry , March 2016 , pp. S183
Copyright
Copyright © European Psychiatric Association 2016
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