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Body mass index (BMI) of drug-naïve psychotic adolescents based on a population of adolescent psychiatric inpatients*

Published online by Cambridge University Press:  05 September 2008

Jaana Juutinen ,
Helinä Hakko ,
V. Benno Meyer-Rochow ,
Pirkko Räsänen ,
Markku Timonen  and
The STUDY-70 research group
Jaana Juutinen*
Affiliation:
Department of Public Health Science and General Practice, University of Oulu, P.O. Box 5000, FIN 90014, Oulu, Finland
Helinä Hakko
Affiliation:
Oulu University Hospital, Department of Psychiatry, P.O. Box 26, 90290 OYS, Oulu, Finland
V. Benno Meyer-Rochow
Affiliation:
Jacobs University (formerly known as International University Bremen), School of Engineering and Science, D-28725 Bremen, Germany
Pirkko Räsänen
Affiliation:
Department of Psychiatry, University of Oulu, P.O. Box 5000, FIN-90014, Finland
Markku Timonen
Affiliation:
Department of Public Health Science and General Practice, University of Oulu, P.O. Box 5000, FIN 90014, Oulu, Finland
*
*Corresponding author. Tel.: +358 8 5375636; fax: +358 8 537 5661.E-mail address: [email protected] (J. Juutinen).
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Abstract

Objective

To investigate the connection between overweight and first-episode schizophrenia spectrum as well as non-schizophrenia spectrum psychiatric disorders in adolescent male and female drug-naïve psychiatric inpatients, whose illness was early onset.

Method

Three hundred twenty-three adolescents with no past or present psychiatric medication, 12–17 years of age, admitted to the psychiatric inpatient care (Oulu University Hospital, Northern Finland) between April 2001 and March 2006. DSM-IV diagnoses were based on the “Schedule for Affective Disorder and Schizophrenia for School-Age Children Present and Lifetime” (K-SADS-PL). An adolescent was defined as overweight if his or her BMI was greater than or equal to the 85th percentile.

Results

Overweight values were highest in drug-naïve adolescent boys with first-episode schizophrenia spectrum (RR: 2.5, 95%CI: 1.08–4.29) and non-schizophrenia spectrum (RR: 2.80, 95%CI: 2.20–3.45) disorders. The RR in girls with non-schizophrenia spectrum disorders was 1.73 (95%CI: 1.31–2.23), but in those with first-episode schizophrenia spectrum disorders RR did not differ from general population.

Conclusions

In our study sample of first-episode schizophrenia spectrum drug-naïve adolescents, overweight was shown to be prevalent in all diagnostic groups other than first-episode schizophrenia spectrum psychotic girls. To the best of our knowledge, this is the first study in which overweight was analyzed and verified among drug-naïve adolescent boys, suffering from first-episode schizophrenia spectrum disorder. To what extent our results are applicable to other regions and study groups, remains to be seen.

Keywords

AdolescenceOverweightPsychotic disordersBody mass indexGender difference
Type
Original article
Information
European Psychiatry , Volume 23 , Issue 7 , October 2008 , pp. 521 - 526
Copyright
Copyright © Elsevier Masson SAS 2008

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Footnotes

*

The STUDY-70 research group: Medical supervisors: Professor Pirkko Räsänen, University of Oulu, Department of Psychiatry; Professor Jaakko Lappalainen, Yale University, School of Medicine, Department of Psychiatry; Professor Mauri Marttunen, Helsinki Central University Hospital, Department of Adolescent Psychiatry, Peijas; Administrative supervisors: Kaisa Riala, MD, PhD, Taru Ollinen, MD, PhD, and Kristian Läksy, MD, PhD, Oulu University Hospital, Department of Psychiatry; Statistical consultants: Helinä Hakko, PhD, and Kaisa Karvonen, B.Sc, Oulu University Hospital, Department of Psychiatry; Senior researchers: Professor Markku Timonen, University of Oulu, Department of Public Health Sciences and General Practice; Researchers: Essi Ilomäki, MD, Risto Ilomäki, MD, Vesa Tikkanen, medical student, University of Oulu, Department of Psychiatry; Matti Laukkanen, M.Sc, Oulu University Hospital, Department of Psychiatry.

References

Allison, D.B.Fontaine, K.R.Heo, M.Mentore, J.L.Cappelleri, J.C.Chandler, L.P.et al.The distribution of body mass index among individuals with and without schizophrenia J Clin Psychiatry. 60 1999 215–220CrossRefGoogle ScholarPubMed
Cameron, D.E.Early schizophrenia Am J Psychiatry. 95 1938 567–578CrossRefGoogle Scholar
Dworkin, R.H.Patterns of sex differences in negative symptoms and social functioning consistent with separate dimensions of schizophrenic psychopathology Am J Psychiatry. 147 1990 347–349Google ScholarPubMed
Gordon, C.T.Frazier, J.A.McKenna, K.Giedd, J.Zametkin, A.Zahn, T.et al.Childhood-onset schizophrenia: an NIMH study in progress Schizophr Bull. 20 1994 697–712CrossRefGoogle ScholarPubMed
Hughes, J.M.Li, L.Chinn, S.Rona, R.J.Trends in growth in England and Scotland, 1972–1994 Arch Dis Child. 76 1997 182–189CrossRefGoogle Scholar
Kautiainen, S.Rimpelä, A.Vikat, A.Virtanen, S.M.Secular trends in overweight and obesity among Finnish adolescents in 1977–1999 Int J Obes Relat Metab Disord. 26 2002 544–552CrossRefGoogle ScholarPubMed
Kelly, D.L.Conley, R.R.Love, R.C.Horn, D.S.Ushchak, C.M.Weight gain in adolescents treated with risperidone and conventional antipsychotic over six months J Child Adolesc Psychopharmacol. 8 1998 151–159CrossRefGoogle ScholarPubMed
Kumra, S.Jacobsen, L.K.Lenane, M.Karp, B.I.Frazier, J.A.Smith, A.K.et al.Childhood-onset schizophrenia: an open-label study of olanzapine in adolescents J Am Acad Child Adolesc Psychiatry. 37 1998 377–385CrossRefGoogle ScholarPubMed
Kaufman, J.Birmaher, B.Brendt, D.Rao, U.Flynn, C.Moreci, P.et al.Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): initial reliability and validity data J Am Acad Child Adolesc Psychiatry. 36 1997 980–988CrossRefGoogle ScholarPubMed
Kim-Cohen, J.Caspi, A.Moffitt, T.E.Harrington, H.Milne, B.J.Poulton, R.Prior juvenile diagnoses in adults with mental disorder: developmental follow-back of a prospective-longitudinal cohort Arch Gen Psychiatry. 60 2003 709–717CrossRefGoogle ScholarPubMed
Lamertz, C.M.Jacobi, C.Yassouridis, A.Arnold, K.Henkel, A.W.Are obese adolescents and young adults at higher risk for mental disorders? A community survey Obes Res. 10 2002 1152–1160CrossRefGoogle Scholar
Mahoney, L.T.Burns, T.L.Stanford, W.Thompson, B.H.Witt, J.D.Rost, C.A.et al.Coronary risk factors measured in childhood and young adult life are associated with coronary artery calcification in young adults: the Muscatine Study J Am Coll Cardiol. 27 1996 277–284CrossRefGoogle Scholar
Martin, A.Landau, J.Leebens, P.Ulizio, K.Cicchetti, D.Scahill, L.et al.Risperidone-associated weight gain in children and adolescents: a retrospective chart review J Child Adolesc Psychopharmacol. 10 2000 259–268CrossRefGoogle ScholarPubMed
McConville, B.J.Arvanitis, L.A.Thyrum, P.T.Yeh, C.Wilkinson, L.A.Chaney, R.O.et al.Pharmacokinetics, tolerability, and clinical effectiveness of quetiapine fumarate: an open-label trial in adolescents with psychotic disorders J Clin Psychiatry. 61 2000 252–260CrossRefGoogle ScholarPubMed
Mäkikyrö, T.H.Hakko, H.H.Timonen, M.J.Lappalainen, J.A.S.Ilomäki, R.S.Marttunen, M.J.et al.Smoking and suicidality among adolescent psychiatric patients J Adolesc Health. 34 2004 250–253CrossRefGoogle ScholarPubMed
Mustillo, S.Worthman, C.Erkanli, A.Keeler, G.Angold, A.Costello, E.J.Obesity and psychiatric disorder: developmental trajectories Pediatrics. 111 2003 851–859CrossRefGoogle ScholarPubMed
Power, C.Lake, J.K.Cole, T.J.Measurement and long-term health risks of child and adolescent fatness Int J Obes. 21 1997 507–526CrossRefGoogle ScholarPubMed
Preston, N.J.Orr, K.G.Date, R.Nolan, L.Castle, D.J.Gender difference in premorbid adjustment of patients with first episode psychosis Schizophr Res. 55 2002 285–290CrossRefGoogle Scholar
Pine, D.S.Cohen, P.Brook, J.Coplan, J.D.Psychiatric symptoms in adolescence as predictors of obesity in early adulthood: a longitudinal study Am J Public Health. 87 1997 1303–1310CrossRefGoogle ScholarPubMed
Ratzoni, G.Gothelf, D.Brand-Gothelf, A.Reidman, J.Kikinzon, L.Gal, G.et al.Weight gain associated with olanzapine and risperidone in adolescent patients: a comparative prospective study J Am Acad Child Adolesc Psychiatry. 41 2002 337–343CrossRefGoogle ScholarPubMed
Ross, R.G.Novins, D.Farley, G.K.Adler, L.E.A 1-year open-label trial of olanzapine in school-age children with schizophrenia J Child Adolesc Psychopharmacol. 13 2003 301–309CrossRefGoogle ScholarPubMed
Richardson, L.P.Garrison, M.M.Drangsholt, M.Mancl, L.LeResche, L.Associations between depressive symptoms and obesity during puberty Gen Hosp Psychiatry. 28 2006 313–320CrossRefGoogle ScholarPubMed
Sullivan, S.H.The onset of schizophrenia Am J Psychiatry. 6 1927 105–134CrossRefGoogle Scholar
Strassnig, M.Brar, J.S.Ganguli, R.Body mass index and quality of life in community-dwelling patients with schizophrenia Schizophr Res. 62 2003 73–76CrossRefGoogle ScholarPubMed
Troiano, R.P.Flegal, K.M.Kuczmarski, R.J.Campbell, S.M.Johnson, C.L.Overweight prevalence and trends for children and adolescents. The National Health and Nutrition Examination Surveys, 1963–1991 Arch Pediatr Adolesc Med. 149 1995 1085–1091CrossRefGoogle Scholar
Vieweg, W.V.R.Sood, A.B.Pandurangi, A.Silverman, J.J.Newer antipsychotic drugs and obesity in children and adolescents. How should we assess drug-associated weight gain? Acta Psychiatr Scand. 111 2005 177–184CrossRefGoogle ScholarPubMed
Vieweg, W.V.R.Kuhnley, L.J.Kuhnley, E.J.Anum, E.A.Sood, B.Pandurangi, A.et al.Body mass index (BMI) in newly admitted child and adolescent psychiatric inpatients Prog Neuropsychopharmacol Biol Psyciahtry. 29 2005 511–515CrossRefGoogle ScholarPubMed
Vila, G.Zipper, E.Dabbas, M.Bertrand, C.Robert, J.J.Ricour, C.et al.Mental disorders in obese children and adolescents Psychosom Med. 66 2004 387–394Google ScholarPubMed
World Health Organization, Obesity: preventing and managing the global epidemic 1998 World Health Organization GenevaGoogle Scholar
www.kaypahoito.fi/xmedia/extra/hoi/hoi50034a.pdfGoogle Scholar
www.kaypahoito.fi/xmedia/extra/hoi/hoi50034b.pdfGoogle Scholar
Wirshing, D.A.Meyer, J.M.Obesity in patients with schizophreniaMayer, J.M.Nasrallah, H.Medical illness and schizophrenia. 2003 American Psychiatric Press Inc. Washington, DC39–55Google Scholar
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