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The BDNF-Val66Met polymorphism modulates parental rearing effects on adult psychiatric symptoms: A community twin-based study

Published online by Cambridge University Press:  15 April 2020

P. Ibarra ,
S. Alemany ,
M. Fatjó-Vilas ,
A. Córdova-Palomera ,
X. Goldberg ,
B. Arias ,
I. González-Ortega ,
A. González-Pinto ,
I. Nenadic  and
L. Fañanás
P. Ibarra
Affiliation:
Anthropology Unit, Department of Animal Biology, Faculty of Biology, University of Barcelona and Biomedicine Institute of the University of Barcelona (IBUB), Avenue Diagonal, 643, 08028Barcelona, Spain
S. Alemany
Affiliation:
Anthropology Unit, Department of Animal Biology, Faculty of Biology, University of Barcelona and Biomedicine Institute of the University of Barcelona (IBUB), Avenue Diagonal, 643, 08028Barcelona, Spain Centre for Biomedical Research Network on Mental Health (CIBERSAM), Doctor Esquerdo, 46, 28007Madrid, Spain
M. Fatjó-Vilas
Affiliation:
Anthropology Unit, Department of Animal Biology, Faculty of Biology, University of Barcelona and Biomedicine Institute of the University of Barcelona (IBUB), Avenue Diagonal, 643, 08028Barcelona, Spain Centre for Biomedical Research Network on Mental Health (CIBERSAM), Doctor Esquerdo, 46, 28007Madrid, Spain
A. Córdova-Palomera
Affiliation:
Anthropology Unit, Department of Animal Biology, Faculty of Biology, University of Barcelona and Biomedicine Institute of the University of Barcelona (IBUB), Avenue Diagonal, 643, 08028Barcelona, Spain Centre for Biomedical Research Network on Mental Health (CIBERSAM), Doctor Esquerdo, 46, 28007Madrid, Spain
X. Goldberg
Affiliation:
Anthropology Unit, Department of Animal Biology, Faculty of Biology, University of Barcelona and Biomedicine Institute of the University of Barcelona (IBUB), Avenue Diagonal, 643, 08028Barcelona, Spain Centre for Biomedical Research Network on Mental Health (CIBERSAM), Doctor Esquerdo, 46, 28007Madrid, Spain
B. Arias
Affiliation:
Anthropology Unit, Department of Animal Biology, Faculty of Biology, University of Barcelona and Biomedicine Institute of the University of Barcelona (IBUB), Avenue Diagonal, 643, 08028Barcelona, Spain Centre for Biomedical Research Network on Mental Health (CIBERSAM), Doctor Esquerdo, 46, 28007Madrid, Spain
I. González-Ortega
Affiliation:
Centre for Biomedical Research Network on Mental Health (CIBERSAM), Doctor Esquerdo, 46, 28007Madrid, Spain Department of Psychiatry, Alava University Hospital (Santiago), EHU/UPV, Kronikgune, Olaguibel 29, Vitoria, Spain
A. González-Pinto
Affiliation:
Centre for Biomedical Research Network on Mental Health (CIBERSAM), Doctor Esquerdo, 46, 28007Madrid, Spain Department of Psychiatry, Alava University Hospital (Santiago), EHU/UPV, Kronikgune, Olaguibel 29, Vitoria, Spain
I. Nenadic
Affiliation:
Department of Psychiatry and Psychotherapy, Jena University Hospital, 07743Jena, Germany
L. Fañanás*
Affiliation:
Anthropology Unit, Department of Animal Biology, Faculty of Biology, University of Barcelona and Biomedicine Institute of the University of Barcelona (IBUB), Avenue Diagonal, 643, 08028Barcelona, Spain Centre for Biomedical Research Network on Mental Health (CIBERSAM), Doctor Esquerdo, 46, 28007Madrid, Spain
*
*Corresponding author. Unitat d’Antropologia, Dep. Biologia Animal, Facultat Biologia, Universitat de Barcelona, Avenue Diagonal 643, 08028 Barcelona, Spain. Tel.: +34 93 402 1461; fax: +34 93 403 5740. E-mail address:lfananas@ub.edu (L. Fañanás).
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Abstract

Purpose:

To test whether firstly, different parental rearing components were associated with different dimensions of psychiatric symptoms in adulthood, secondly BDNF-Val66Met polymorphism moderated this association and thirdly, this association was due to genetic confounding.

Method:

Perceived parental rearing according to Parental Bonding Instrument (PBI), psychiatric symptoms evaluated with the Brief Symptom Inventory (BSI) and the BDNF-Val66Met polymorphism were analyzed in a sample of 232 adult twins from the general population.

Results:

In the whole sample, paternal care was negatively associated with depression. Maternal overprotection was positively associated with paranoid ideation, obsession-compulsion and somatization. Gene-environment interaction effects were detected between the BDNF-Val66Met polymorphism and maternal care on phobic anxiety, paternal care on hostility, maternal overprotection on somatization and paternal overprotection also in somatization. In the subsample of MZ twins, intrapair differences in maternal care were associated with anxiety, paranoid ideation and somatization.

Conclusions:

Met carriers were, in general, more sensitive to the effects of parental rearing compared to Val/Val carriers in relation to anxiety and somatization. Contra-intuitively, our findings suggest that high rates of maternal care might be of risk for Met carriers regarding anxiety. Results from analyses controlling for genetic confounding were in line with this finding.

Keywords

Parental rearingPsychiatric symptomsBDNF-Val66Met polymorphismTwinsGeneral populationGene-environment interaction
Type
Original articles
Information
European Psychiatry , Volume 29 , Issue 5 , June 2014 , pp. 293 - 300
Copyright
Copyright © Elsevier Masson SAS 2014

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Footnotes

1

These authors contributed equally to this work.

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