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Axis I psychiatric diagnoses in adolescents and young adults with 22q11 deletion syndrome

Published online by Cambridge University Press:  15 April 2020

O.Y. Ousley*
Affiliation:
Emory University School of Medicine, Emory Autism Center, Department of Psychiatry and Behavioral Sciences, 1551 Shoup Court, 30322Atlanta, Georgia, United States
E. Smearman
Affiliation:
Medical Scientist Training Program, Emory University School of Medicine, School of Medicine Bldg., Suite 375-B, 1648 Pierce Drive, 30322Atlanta, Georgia, United States Emory University Rollins School of Public Health, Department of Behavioral Sciences and Health Education30322Atlanta, Georgia, United States
S. Fernandez-Carriba
Affiliation:
Emory University School of Medicine, Emory Autism Center, Department of Psychiatry and Behavioral Sciences, 1551 Shoup Court, 30322Atlanta, Georgia, United States Emory University, Departments of Pediatrics30322Atlanta, Georgia, United States
K.A. Rockers
Affiliation:
Emory University School of Medicine, Department of Human Genetics30322Atlanta, Georgia, United States
K. Coleman
Affiliation:
Emory University School of Medicine, Department of Human Genetics30322Atlanta, Georgia, United States Children's Healthcare of Atlanta, 1405 Clifton Road NE, 30322Atlanta, Georgia, United States Nell Hodgson Woodruff School of Nursing30322Atlanta, Georgia, United States
E.F. Walker
Affiliation:
Emory University School of Medicine, Emory Autism Center, Department of Psychiatry and Behavioral Sciences, 1551 Shoup Court, 30322Atlanta, Georgia, United States Emory University, Department of Psychology30322Atlanta, Georgia, United States
J.F. Cubells
Affiliation:
Emory University School of Medicine, Emory Autism Center, Department of Psychiatry and Behavioral Sciences, 1551 Shoup Court, 30322Atlanta, Georgia, United States Emory University School of Medicine, Department of Human Genetics30322Atlanta, Georgia, United States
*
*Corresponding author. Tel.: +1 404 727 8350; fax: +1 404 727 3969. E-mail address:[email protected] (O.Y. Ousley).
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Abstract

Background

22q11.2 deletion syndrome (22q11DS) associates with schizophrenia spectrum disorders (SSDs), autism spectrum disorders (ASDs), and other psychiatric disorders, but co-occurrence of diagnoses are not well described.

Methods

We evaluated the co-occurrence of SSDs, ASDs and other axis I psychiatric diagnoses in 31 adolescents and adults with 22q11DS, assessing ASDs using either stringent Collaborative Program for Excellence in Autism (ASD-CPEA) criteria, or less stringent DSM-IV criteria alone (ASD-DSM-IV).

Results

Ten (32%) individuals met criteria for an SSD, five (16%) for ASD-CPEA, and five others (16%) for ASD-DSM-IV. Of those with ASD-CPEA, one (20%) met SSD criteria. Of those with ASD-DSM-IV, four (80%) met SSD criteria. Depressive disorders (8 individuals; 26%) and anxiety disorders (7; 23%) sometimes co-occurred with SSDs and ASDs. SSDs, ASDs, and anxiety occurred predominantly among males and depression predominantly among females.

Conclusions

Individuals with 22q11DS can manifest SSDs in the presence or absence of ASDs and other axis I diagnoses. The results suggest that standard clinical care should include childhood screening for ASDs, and later periodic screening for all axis I diagnoses.

Type
Original article
Copyright
Copyright © European Psychiatric Association

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