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Autoantibodies are not Predictive Markers for the Development of Depressive Symptoms in a Population-Based Cohort of Older Adults

Published online by Cambridge University Press:  15 July 2015

R.A. Iseme ,
M. McEvoy ,
B. Kelly ,
L. Agnew ,
J. Attia ,
F.R. Walker ,
C. Oldmeadow  and
M. Boyle
R.A. Iseme*
Affiliation:
Centre for Clinical Epidemiology and Biostatistics, Faculty of Health, School of Medicine and Public Health, University of Newcastle, Callaghan, NSW, Australia Hunter Medical Research Institute Building, Level 3, Kookaburra CircuitNew Lambton Heights, 2305NSWAustralia
M. McEvoy
Affiliation:
Centre for Clinical Epidemiology and Biostatistics, Faculty of Health, School of Medicine and Public Health, University of Newcastle, Callaghan, NSW, Australia Hunter Medical Research Institute Building, Level 3, Kookaburra CircuitNew Lambton Heights, 2305NSWAustralia
B. Kelly
Affiliation:
Centre for Translational Neuroscience and Mental Health Research, The University of Newcastle, Callaghan, NSWAustralia
L. Agnew
Affiliation:
Brain Behaviour Research Group, School of Science and Technology, University of New England, McClymont Building (W34) 353, Armidale, 2351NSWAustralia
J. Attia
Affiliation:
Centre for Clinical Epidemiology and Biostatistics, Faculty of Health, School of Medicine and Public Health, University of Newcastle, Callaghan, NSW, Australia Hunter Medical Research Institute Building, Level 3, Kookaburra CircuitNew Lambton Heights, 2305NSWAustralia Division of Medicine, John Hunter Hospital, Lookout Road, New Lambton Heights, 2305NSWAustralia
F.R. Walker
Affiliation:
Laboratory of Affective Neuroscience, Medical Sciences MSB306, University of Newcastle, University Drive, Callaghan, 2308NSWAustralia
C. Oldmeadow
Affiliation:
Centre for Clinical Epidemiology and Biostatistics, Faculty of Health, School of Medicine and Public Health, University of Newcastle, Callaghan, NSW, Australia Hunter Medical Research Institute Building, Level 3, Kookaburra CircuitNew Lambton Heights, 2305NSWAustralia
M. Boyle
Affiliation:
Division of Medicine, John Hunter Hospital, Lookout Road, New Lambton Heights, 2305NSWAustralia
*
*Corresponding author. Hunter Medical Research Institute Building, Level 3, Kookaburra Circuit, New Lambton Heights, NSW 2305, Australia. Tel.: +61 0403587865; fax: +61 2404220044. E-mail address: [email protected] (R.A. Iseme).
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Abstract

Background

Autoantibodies have been implicated in the etiologic pathway of depressive disorders. Here, we determine the association between the presence of a panel of autoantibodies at baseline and change in depression symptom score over 5-year follow-up in a cohort of healthy elderly Australians.

Methods

Serum samples from 2049 randomly selected subjects enrolled in the Hunter Community Study (HCS) aged 55–85 years were assayed for a range of autoimmune markers (anti-nuclear autoantibodies, extractable nuclear antigen autoantibodies, anti-neutrophil cytoplasmic autoantibodies, thyroid peroxidase autoantibodies, tissue transglutaminase autoantibodies, anti-cardiolipin autoantibodies, rheumatoid factor and cyclic citrullinated peptide autoantibodies) at baseline. Depression symptom score was assessed using the Centre for Epidemiological Study (CES-D) scale at baseline and 5 years later.

Results

Autoantibody prevalence varied amongst our sample with ANA being the most prevalent; positive in 16% and borderline in 36% of study population. No evidence for a relationship was found between change in CES-D score over time and any autoimmune marker. Statins and high cholesterol were significantly associated with change in CES-D score over time in univariate analysis; however, these were probably confounded since they failed to remain significant following multivariable analysis.

Conclusions

Autoantibodies were not associated with change in CES-D score over time. These findings point to an absence of autoimmune mechanisms in the general population or in moderate cases of depression.

Keywords

AutoantibodiesDepressionAutoimmunityCentre for Epidemiological Study Depression (CES-D) scaleDepressive symptomsAutoimmune markers
Type
Original article
Information
European Psychiatry , Volume 30 , Issue 6 , September 2015 , pp. 694 - 700
Copyright
Copyright © Elsevier Masson SAS 2015

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Footnotes

Abbreviations: CES-D, Centre for Epidemiological Study Depression; SLE, Systemic lupus erythematosus; ANA, Anti-nuclear autoantibodies; ENA, Extractable nuclear antigen autoantibodies; Sm, Anti-Smith; RNP, Ribo-nucleoprotein; SS-A, Sjogren's Syndrome A; SS-B, Sjogren's Syndrome B; SCL-70, Topoisomerase-I; JO-1, Autoantibodies against amino acyl-tRNA synthetases; IgG, Immunoglobulin G; IgA, Immunoglobulin A; ANCA, Anti-neutrophil cytoplasmic autoantibodies; TPO-Ab, Thyroid peroxidase autoantibodies; TTG-Ab, Tissue transglutaminase autoantibodies; ACGA, Anti-cardiolipin autoantibodies; RHF, Rheumatoid factor; CCP-Ab, Cyclic citrullinated peptide autoantibodies; hsCRP, High sensitivity C-reactive protein; DNA, Deoxyribonucleic acid; HCS, Hunter community study; LDL, Low-density lipoprotein; TGs, Triglycerides; BMI, Body Mass Index; PAL, Physical activity level; ARFS, Australian Recommended Food Score; FFQ, Food Frequency Questionnaire; DQESv2, Dietary Questionnaire for Epidemiological Studies version 2; AGHE, Australian Guide to Healthy Eating; ELISA, Enzyme-Linked Immunosorbent Assay; GPL, IgG phospholipid units; IU/mL, International unit per millilitre; EU/mL, Enzyme immunoassay units per millilitre; SD, Standard deviation; DAGs, Directed Acyclic Graphs; CNS, Central nervous system.

References

Aljadani, H.M., Patterson, A., Sibbritt, D., Hutcheson, M.J., Jensen, M.E., Collins, C.E.Diet quality measured by fruit and vegetable intake, predicts weight change in young women. J Obesity 2013;2013:10. http://dx.doi.org/10.1155/2013/525161.CrossRefGoogle ScholarPubMed
Almeida-Montes, L.G., Valles-Sanchez, V., Moreno-Aguilar, J., Chavez-Balderas, R.A., Garcia-Marin, J.A., Cortes Sotres, J.F., et al.Relation of serum cholesterol, lipid, serotonin and tryptophan levels to severity of depression and to suicide attempts. J Psychiatr Neurosci 2000;25:371–377.Google ScholarPubMed
Apter, A., Laufer, N., Bar-Sever, M., Har-Even, D., Ofek, H., Weizman, A.Serum cholesterol, suicidal tendencies, impulsivity, aggression, and depression in adolescent psychiatric inpatients. Biol Psychiatry 1999;46:532–541.CrossRefGoogle ScholarPubMed
Arnett, F.C., Reveille, J.D., Moutsopoulos, H.M., Georgescu, L., Elkon, K.B.Ribosomal P autoantibodies in systemic lupus erythematosus. Frequencies in different ethnic groups and clinical and immunogenetic associations. Arthritis Rheum 1996;39(11):1833–1839.CrossRefGoogle ScholarPubMed
Beekman, A.T., Deeg, D.J., Van Limbeek, J., Braam, A.W., De Vries, M.Z., Van Tillburg, W.Criterion validity of the Centre for Epidemiological Studies Depression Scale (CES-D): results from a community-based sample of older subjects in the Netherlands. Psychol Med 1997;27(1):231–235.CrossRefGoogle Scholar
Bizzaro, N.Autoantibodies as predictors of disease: the clinical and experimental evidence. Autoimmun Rev 2007;6:325.CrossRefGoogle ScholarPubMed
Boston, F.P., Serdar, M.D., Reveley, M.A.Cholesterol and mental disorder. Br J Psychiatry 1996;169:682–689.CrossRefGoogle ScholarPubMed
Chandrashekar, K., Meti, V., Saritha, M.K.Antidepressant activity of statins in albino mice an experimental study. IJCRR 2013;5(6):42–45.Google Scholar
Cheng, P., Jiang, T., Wuyang, J., Chen, Y.Depression, another autoimmune disease from the view of autoantibodies. Med Hypotheses 2009;173(4):508–509.CrossRefGoogle Scholar
Collins, E.C., Young, F.A., Hodge, A.Diet quality is associated with higher nutrient intake and self rated health in middle aged women. J Am Coll Nutr 2008;27(1):146–157.CrossRefGoogle Scholar
Deberdt, R., van Hooren, J., Biesbrouk, M., Amery, W.Antinuclear factor positive in mental depression: a single entity?. Biol Psychiatry 1976;11(1):69–74.Google Scholar
Fessel, W.J.Macroglobin elevations in functional mental illness. Nature 1962;193:1005.CrossRefGoogle ScholarPubMed
Gao, H.X., Campbell, S.R., Min-Hui, C., Zong, P., hee Hwang, J., Gulinello, M., et al.Depression is an early disease manifestation in lupus-prone MRL.lpr mice. J Neuroimmunol 2009;207(1–2):45–56.CrossRefGoogle ScholarPubMed
Gao, H.X., Sanders, E., Tieng, A.T., Putterman, C.Sex and autoantibody titers determine the development of neuropsychiatric manifestations in lupus-prone mice. J Neuroimmunol 2010;229(1–2):112–122.CrossRefGoogle ScholarPubMed
Greenland, S., Pearl, J., Robins, M.J.Causal diagrams for epidemiologic research. Epidemiology 1999;10(1):37–48.CrossRefGoogle ScholarPubMed
Haringsma, R., Engels, G.I., Beekman, A.T., Spinhoven, P.The Criterion validity of the Centre for Epidemiological Studies Depression Scale (CES-D) in a sample of selfreferred elderly with depressive symptomatology. Int J Geriatr Psychiatry 2004;19(6):558–563.CrossRefGoogle Scholar
Harris, B., Othman, S., Davies, J.A., Weppner, G.J., Richards, C.J., Newcombe, R.G., et al.Association between postpartum thyroid dysfunction and thyroid antibodies and depression. BMJ 1992;305(6846):152–156.CrossRefGoogle ScholarPubMed
Hornig, M., Amsterdam, J.D., Kamoun, M., Goodman, D.B.Autoantibody disturbances in affective disorders: a function of age and gender?. J Affect Dis 1999;55(1):29–37.CrossRefGoogle ScholarPubMed
Iseme, R.A., McEvoy, M., Kelly, B., Agnew, L., Attia, J., Walker, F.R.Autoantibodies and depression: evidence for a causal link?. Neurosci Biobehav Rev 2014;40:62–79.CrossRefGoogle ScholarPubMed
Julian, L.J., Gregorich, S.E., Tonner, C., Yazdany, J., Trupin, L., Criswell, L.A., et al.Using the center for epidemiologic studies depression scale to screen for depression in systemic lupus erythematosus. Arthritis Care Res 2011;63(6):884–890. http://dx.doi.org/10.1002/acr.20447.CrossRefGoogle ScholarPubMed
Kuijpens, J.L., Vader, H.L., Drexhage, H.A., Wiersinga, W.M., Van Son, M.J., Pop, V.J.Thyroid peroxidase antibodies during gestation are a marker for subsequent depression postpartum. Eur J Endocrinol 2001;145(5):579–584.CrossRefGoogle ScholarPubMed
Le Donne, M., Settineri, S., Benvenga, S.Early postpartum alexithymia and risk for depression: relationship with serum thyrotrophin, free thyroid hormones and thyroid autoantibodies. Psychoneuroendocrinology 2012;37(4):433–519.CrossRefGoogle ScholarPubMed
Legros, S., Mendelwicz, J., Wybran, J.Immunoglobulins, autoantibodies and other serum protien fractions in psychiatric disorders. Eur Arch Psychiatr Nuerol Sci 1985;235(1):9–11.CrossRefGoogle Scholar
McEvoy, M., Smith, W., D’Este, C., Duke, J., Peel, R., Schofield, P., et al.The Hunter Community Study. Int J Epidemiol 2010;39(6):1452–1463.CrossRefGoogle ScholarPubMed
Nakao, M., Yano, E.Relationship between major depression and high serum cholesterol in Japanese men. Tohoku J Exp Med 2004;204:273–287.CrossRefGoogle ScholarPubMed
Nakao, M., Ando, K., Nomura, S., Kuboki, T., Uehara, Y., Toyooka, T., et al.Depressive mood accompanies hypercholesterolemia in Japanese young adults. Jpn Heart J 2001;42:739–748.CrossRefGoogle Scholar
Nojima, Y., Minota, S., Yamada, A., Takaku, F., Aotsuka, S., Yokohari, R.Correlation of antibodies to ribosomal P protein with psychosis in patientswith systemic lupus erythematosus. Ann Rheum Dis 1992;51(9):1053–1055.CrossRefGoogle Scholar
O’Neil, A., Sanna, L., Redlich, C., Sanderson, K., Jacka, F., Williams, J.L., et al.The impact of statins on psychological wellbeing: a systematic review and metaanalysis. BMC Med 2012;10:154.CrossRefGoogle Scholar
Parsaik, K.A., Singh, B., Hassan, M.M., Singh, K., Mascarenhas, S.S., Williams, M.D., et al.Statin use and risk of depression: a systematic review and meta-analysis. J Affect Dis 2014;160:62–67.CrossRefGoogle ScholarPubMed
Pop, V.J., de Rooy, H.A., Vader, H.L., van der Heide, D., van Son, M., Komproe, I.H., et al.Postpartum thyroid dysfunction and depression in an unselected population. N Engl J Med 1991;324(25):1815–1816.Google Scholar
Potter, J.L., Collins, C.E., Brown, L.J., Hure, A.J.Diet quality of Australian breast cancer survivors: a cross-sectional analysis from the Australian Longitudinal Study on Women's Health. J Hum Nutr Diet 2014;27:569–576.CrossRefGoogle ScholarPubMed
Radloff, L.S.The CES-D Scale. Appl Psychol Meas 1977;1(3):385401.CrossRefGoogle Scholar
Sakic, B., Szechtman, H., Denburg, S.D., Denburg, J.A.Immunosuppressive treatment prevents behavioural deficit in autoimmune MRL-lpr mice. Physiol Behav 1995;58(4):797–802.Google ScholarPubMed
Sakic, B., Denburg, J.A., Denburg, S.D., Szechtman, H.Blunted sensitivity to sucrose reward in autoimmune MRL-lpr mice: a curve shift study. Brain Res Bull 1996;41(5):305–311.CrossRefGoogle Scholar
Sakic, B., Kolb, B., Whishaw, I.Q., Gonry, G., Szechtman, H., Denburg, J.A.Immunosuppression prevents neuronal atrophy in lupus prone mice: evidence for brain damage induced by autoimmune disease. J Neuroimmunol 2000;111(1–2):93101.CrossRefGoogle ScholarPubMed
Sakić, B., Szechtman, H., Denburg, J.A.Neurobehavioural alterations in autoimmune mice. Neurosci Biobehav Rev 1997;21(3):327–340.Google Scholar
Stanojcic, M., Loheswaran, G., Xu, L., Hoffman, S.A., Sakic, B.Intrathecal antibodies and brain damage in autoimmune MRL mice. Brain Behav Immun 2010;24(2):289–297.CrossRefGoogle ScholarPubMed
Tandon, V., Bano, G., Khajuria, V., Parihar, A., Gupta, S.Pleiotropic effects of statins. Indian J Pharmacol 2005;37:77–85.CrossRefGoogle Scholar
Tanskanen, A., Vartiainen, E., Tuomilehto, J., Viinamaki, H., Lehtonen, J., Puska, P.High serum cholesterol and risk of suicide. Am J Psychiatry 2000;157:648–650.CrossRefGoogle ScholarPubMed
Tuccori, M., Montagnani, S., Mantarro, S., Capogrosso-Sansone, A., Ruggiero, E., Saporiti, A., et al.Neuropsychiatric adverse events associated with statins: epidemiology, pathophysiology, prevention and management. CNS Drugs 2014;28(3):249–272.CrossRefGoogle ScholarPubMed
William, S., Sakic, B., Hoffman, S.A.Circulating brain-reactive autoantibodies and behavioural deficits in MRL model of CNS lupus. J. Neuroimmunol 2010;218(1–2):73–82.CrossRefGoogle Scholar
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