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Association of regional grey matter abnormalities with cognitive functions in the at risk mental state

Published online by Cambridge University Press:  16 April 2020

S.J. Borgwardt ,
E.W. Radue ,
P.K. McGuire  and
A. Riecher-Rössler
S.J. Borgwardt
Affiliation:
Department of Outpatient Psychiatry University Hospital Basel, Basel, Switzerland Department of Neuroradiology, University Hospital Basel, Basel, Switzerland Institute of Psychiatry, King's College, London, United Kingdom
E.W. Radue
Affiliation:
Department of Neuroradiology, University Hospital Basel, Basel, Switzerland
P.K. McGuire
Affiliation:
Institute of Psychiatry, King's College, London, United Kingdom
A. Riecher-Rössler
Affiliation:
Department of Outpatient Psychiatry University Hospital Basel, Basel, Switzerland

Abstract

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Objective

There is some evidence that psychosis and its prodrome are associated with neuroanatomical abnormalities and cognitive deficits. However, the brain structure - cognition associations in this disorder are less clear. The aim of the study was to investigate brain structure – cognition associations in individuals with an At Risk Mental State (ARMS) relative to patients with first-episode psychosis and healthy volunteers.

Methods

The subjects were recruited through a specialised clinic for the early detection of psychosis (FEPSY) at the Psychiatric Outpatient Department, University Hospital Basel. We examined structural brain abnormalities, identified using voxel-based morphometry (VBM), and cognitive function (general intelligence, attention, executive function, and working memory) in 32 individuals at high risk of developing psychosis (ARMS), 22 patients with a first-episode psychosis and 11 healthy volunteers.

Results

We expect that regional grey matter volume abnormalities are associated with specific cognitive deficits in people with an ARMS.

Conclusions

We predict that some associations are specific to individuals with an ARMS and may be a correlate of their increased vulnerability to psychosis. Furthermore, we expect structure – cognition associations within the high risk group to be associated with the subsequent onset of psychosis.

Type
S18. Symposium: Can we Improve the Prediction of the Onset of Psychosis
Information
European Psychiatry , Volume 22 , Issue S1: 15th AEP Congress - Abstract book - 15th AEP Congress , March 2007 , pp. S31
Copyright
Copyright © European Psychiatric Association 2007
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