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Association between inflammatory parameters and neuropsychiatric symptoms in COVID-19 patients treated in hospital del mar Post-COVID psychiatry functional unit

Published online by Cambridge University Press:  19 July 2023

L. Vargas Puértolas ,
T. Legido Gil ,
E. Pechuán Martínez ,
À. Arroyo Núñez  and
S. Oller Canet
L. Vargas Puértolas*
Affiliation:
Psychiatry
T. Legido Gil
Affiliation:
Psychology
E. Pechuán Martínez
Affiliation:
Psychiatry
À. Arroyo Núñez
Affiliation:
Mental health nurse, Hospital del Mar, Barcelona, Spain
S. Oller Canet
Affiliation:
Psychiatry
*
*Corresponding author.

Abstract

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Introduction

There is increasing interest in the association between neuropsychiatric symptoms in patients with COVID-19 and the proinflammatory status of the disease. Hospital del Mar Post-Covid Psychiatry Unit carried out a descriptive study to analyze the link between inflammation and mental health symptoms in COVID-19 patients.

Objectives

Relate inflammation parameters to the presence of neuropsychiatric symptoms in COVID-19 patients treated at the Hospital del Mar Post-Covid Psychiatry Unit.

Methods

A database of patients evaluated by the Post-covid Psychiatry unit was developed. Clinical variables, whether hospitalization is required and inflammation indicators during COVID-19 infection (PCR and IL-6 analytical values) were recorded.

Three screening scales for psychiatric symptoms were given to the patients: PHQ-9 for depression (1-4: minimal depression, 5-9: mild, 10-14: moderate, 15-19: moderately severe, 20-27: severe), GAD-7 for anxiety (cutoff point >=6) and PCL-5 for post-traumatic stress symptoms (cutoff point >6).

T-student statistics for independent samples and the pearson correlation were used to relate inflammation parameters to depression, anxiety and post-traumatic stress symptoms obtained from the scales.

Results

149 patients were attended between may 2020 and april 2021. 78 patients had PCR value and 52 had IL-6 value. There is no correlation between the score obtained on the PHQ-9, GAD-7 and PCL-5 scales and PCR or IL-6 value.

There is no relation between being hospitalized for covid infection and the values of PHQ9 and GAD7. Patients hospitalized had lower scores in PCL-5 scale (t=2.67, p=0.009). There are no differences in the scale scores among patients requiring orotracheal intubation or not.

Conclusions

In this descriptive study, inflammation parameters were not related with psychiatric symptoms in COVID-19 patients. Neither association was found between the inflammation parameters and the severity of COVID-19 symptoms, measured in terms of hospitalization requirement.

Disclosure of Interest

None Declared

Type
Abstract
Information
European Psychiatry , Volume 66 , Special Issue S1: Abstracts of the 31st European Congress of Psychiatry , March 2023 , pp. S408
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of the European Psychiatric Association
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