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ARIPIPRAZOLE INDUCED COMPULSIVE EATING DISORDER: A CASE REPORT

Published online by Cambridge University Press:  19 July 2023

M. Turki ,
A. Samet ,
F. Sahnoun ,
F. Jemil ,
S. Ellouze ,
N. Halouani  and
J. Aloulou
M. Turki
Affiliation:
Psychiatry « B », Hedi Chaker university hospital, sfax, Tunisia
A. Samet*
Affiliation:
Psychiatry « B », Hedi Chaker university hospital, sfax, Tunisia
F. Sahnoun
Affiliation:
Psychiatry « B », Hedi Chaker university hospital, sfax, Tunisia
F. Jemil
Affiliation:
Psychiatry « B », Hedi Chaker university hospital, sfax, Tunisia
S. Ellouze
Affiliation:
Psychiatry « B », Hedi Chaker university hospital, sfax, Tunisia
N. Halouani
Affiliation:
Psychiatry « B », Hedi Chaker university hospital, sfax, Tunisia
J. Aloulou
Affiliation:
Psychiatry « B », Hedi Chaker university hospital, sfax, Tunisia
*
*Corresponding author.

Abstract

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Introduction

Aripiprazole is a newer atypical antipsychotic with a favorable side-effect profile, especially a low propensity to result in metabolic syndromes.It is effective at treating bipolar disorder, the positive symptoms of schizophrenia and has the potential to treat negative and cognitive symptoms.

However, prior studies suggested that aripiprazole seem to be associated to a risk of inducing certain impulse control behaviors, such as uncontrollable gambling, hyper sexuality, as well as compulsive eating.

Objectives

We proposed to assess the evidence for compulsive eating associated with the use of aripiprazole.

Methods

We report a rare case of new onset aripiprazole induced compulsive eating behavior in a patient with bipolar disorder. Then, we conducted a literature review using“PubMed” database and keywords “Aripiprazole”, “Impulse Control Behaviors”, “Compulsive Eating”.

Results

He was a 21-year-old patient, diagnosed with bipolar 1 disorder. He was prescribed Aripiprazole, after a neuroleptic malignant syndrome induced by haloperidol (which was prescribed during the first episode psychosis).

One month following the treatment initiation, the patient complained of eating excessively. He was not able to control his eating and gained 30 Kg over the period of 4 months. Metabolic assessment showed a hypercholesterolemia.

Conclusions

Aripiprazole is a promising novel antipsychotic in mental diseases. However current evidence associates compulsive behaviors like eating with the use of Aripiprazole, probably due to the drug affinity to 5-HT receptors. More studies are needed to confirm this rare side effect.

Disclosure of Interest

None Declared

Type
Abstract
Information
European Psychiatry , Volume 66 , Special Issue S1: Abstracts of the 31st European Congress of Psychiatry , March 2023 , pp. S847
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of the European Psychiatric Association
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