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Alcohol related cognitive impairments in schizophrenia patients : A case-control study

Published online by Cambridge University Press:  19 July 2023

B. Angerville ,
N. Vaucher ,
F. Gierski ,
F. Benzerouk ,
S. Walesa ,
J. Seree ,
M.-C. Bralet ,
A. Benyamina ,
M. Naassila  and
A. Dervaux
B. Angerville*
Affiliation:
Filière universitaire d’addictologie, EPS Barthélemy Durand, Etampes UR PSYCOMADD, Université Paris saclay, Hopital paul Brousse, Villejuif Institut de Psychiatrie (GDR 3557), CNRS, Paris
N. Vaucher
Affiliation:
Service de Psychiatrie, Centre hospitalier Abbeville, Abbeville
F. Gierski
Affiliation:
Institut de Psychiatrie (GDR 3557), CNRS, Paris Cognition Health Society Laboratory (C2S - EA 6291), University of Reims Champagne Ardenne
F. Benzerouk
Affiliation:
Institut de Psychiatrie (GDR 3557), CNRS, Paris Department of Psychiatry, Marne Public Mental Health Institution & Reims University Hospital, Reims
S. Walesa
Affiliation:
Crisalid department, EPSM Oise, Clermont-de-l’oise
J. Seree
Affiliation:
Service de Psychiatrie, Centre hospitalier Abbeville, Abbeville
M.-C. Bralet
Affiliation:
Institut de Psychiatrie (GDR 3557), CNRS, Paris Crisalid department, EPSM Oise, Clermont-de-l’oise
A. Benyamina
Affiliation:
UR PSYCOMADD, Université Paris saclay, Hopital paul Brousse, Villejuif Institut de Psychiatrie (GDR 3557), CNRS, Paris
M. Naassila
Affiliation:
Institut de Psychiatrie (GDR 3557), CNRS, Paris GRAP U 1247, INSERM-Université Picardie Jules Verne, Amiens, France
A. Dervaux
Affiliation:
Filière universitaire d’addictologie, EPS Barthélemy Durand, Etampes UR PSYCOMADD, Université Paris saclay, Hopital paul Brousse, Villejuif Institut de Psychiatrie (GDR 3557), CNRS, Paris
*
*Corresponding author.

Abstract

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Introduction

Cognitive impairment is a well-recognized key feature of schizophrenia. However, these cognitive impairments may be worsened by alcohol consumption. Up to 80% of patients with alcohol use disorders (AUD) display cognitive impairments. Screening for those impairments with a full neuropsychological assessment may be difficult. The Brief Evaluation Alcohol-Related Neuropsychological Impairments (BEARNI) is a specific tool for screening those impairments easy to implement in in clinical practice (Ritz et al. Alcoholism: Clinical and Experimental Research 2015; 39, 2249-60). To our knowledge, no previous studies have assessed the alcohol-related cognitive impairments using the BEARNI test in schizophrenia patients.

Objectives

The objective of the study was to compare BEARNI mean scores between a group of schizophrenia patients with alcohol use disorders and a group of schizophrenia patients without alcohol use disorder.

Methods

39 patients with schizophrenia and AUD (SCZ/AUD +) (82% males, mean age 44.9 ± 11.0 years-old) and 49 patients with schizophrenia without AUD (SCZ/AUD-) (65% males, mean age 42.6 ± 11.4 years-old) consecutively included in the study, were assessed using the BEARNI test. All patients met DSM-5 criteria for schizophrenia and AUD. Demographic and clinical variables were also collected, using the Alcohol Use Disorders Identification Test (AUDIT) and the Positive and Negative Syndrome Scale (PANSS). The primary endpoint of the study was the difference in BEARNI cognitive mean scores between the SCZ/AUD+ and SCZ/AUD- groups.

Results

There was no difference between the two groups regarding demographic variables or PANSS mean scores (59.1 ± 12.8 vs 58.1 ± 14.0; t=-0.3; p=0.7). The AUDIT mean score was higher in the group of patients SCZ/AUD+ (20.6 ± 7.8 vs 1.6 ± 1.5; t=-14.7; p<0.0001). Total BEARNI and cognitive BEARNI mean scores were significantly lower in the group of patients SCZ/AUD+ compared to the group of patients SCZ/AUD- (10.6 ± 4.8 vs 12.6 ± 5.2; t=1.8, p=0.03 and 8.1 ± 3.9 vs 9.8 ± 3.6 t=2.0, p=0.04, respectively). The mean subscores of delayed verbal memory, alphabetical ordination, and alternating verbal fluency subtests were also significantly lower in the group of patients SCZ/+ group (respectively 1,0 ± 0.9 vs 1.6 ± 1.2, t= 2.5, p=0.01; 2,1 ± 1.2 vs 2.5 ± 1.1, t= 1.6, p=0.04; 3.3 ±1.5 vs 3.8 ± 1.5, t= 1.8, p=0.03).

Conclusions

The present study found cognitive impairments using BEARNI test in schizophrenia patients with AUD compared to their counterparts without AUD. Screening alcohol related cognitive impairments using BEARNI could be easier in patients in schizophrenia patients with AUD than usual neurocognitive assessments

Disclosure of Interest

None Declared

Type
Abstract
Information
European Psychiatry , Volume 66 , Special Issue S1: Abstracts of the 31st European Congress of Psychiatry , March 2023 , pp. S335
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of the European Psychiatric Association
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