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Acute and Long-term Overall Severity of Bipolar Disorder Related to Sicam-1 and Svcam-1 Serum Levels in Bipolar Depression

Published online by Cambridge University Press:  15 April 2020

B. Dunjic-Kostic ,
M. Pantovic ,
N. Petronijevic ,
M. Velimirovic ,
T. Nikolic ,
M. Lackovic ,
A. Damjanovic ,
S. Totic-Poznanovic ,
A. Jovanovic  and
M. Ivkovic
B. Dunjic-Kostic
Affiliation:
Affective disorders, Clinic for Psychiatry Clinical Centre of Serbia, Belgrade, Serbia
M. Pantovic
Affiliation:
Affective disorders, Clinic for Psychiatry Clinical Centre of Serbia, Belgrade, Serbia
N. Petronijevic
Affiliation:
Neurobiochemistry, Institute of Clinical and Medical Biochemistry and School of Medicine University of Belgrade Belgrade Serbia, Belgrade, Serbia
M. Velimirovic
Affiliation:
Neurobiochemistry, Institute of Clinical and Medical Biochemistry and School of Medicine University of Belgrade Belgrade Serbia, Belgrade, Serbia
T. Nikolic
Affiliation:
Neurobiochemistry, Institute of Clinical and Medical Biochemistry and School of Medicine University of Belgrade Belgrade Serbia, Belgrade, Serbia
M. Lackovic
Affiliation:
Affective disorders, Clinic for Psychiatry Clinical Centre of Serbia, Belgrade, Serbia
A. Damjanovic
Affiliation:
Affective disorders, Clinic for Psychiatry Clinical Centre of Serbia, Belgrade, Serbia
S. Totic-Poznanovic
Affiliation:
Affective disorders, Clinic for Psychiatry Clinical Centre of Serbia, Belgrade, Serbia
A. Jovanovic
Affiliation:
Affective disorders, Clinic for Psychiatry Clinical Centre of Serbia, Belgrade, Serbia
M. Ivkovic
Affiliation:
Affective disorders, Clinic for Psychiatry Clinical Centre of Serbia, Belgrade, Serbia

Abstract

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Introduction

Interplay between nervous and immune systems plays an important part in clinical presentation and course of affective disorders.

Aims

The aim of the study has been to assess the relation between soluble vascular cell adhesion molecule-1 (sVCAM-1) and soluble intercellular cell adhesion molecule-1 (sICAM-1), in acute and remission phase of bipolar depression, in regard to acute and long-term measures of overall severity of the bipolar disorder.

Methods

The study has explored serum levels of sVCAM-1 and sICAM-1 in 43 patients with bipolar depression. The adhesion molecules’ levels of patient group have been analyzed in acute and remission phases, in regard to bipolarity index (BPIX) and in regard to global functioning (measured by Global Assesment of Functioning Scale- GAF)

Results

The acute serum levels of sICAM-1 have been associated to BPIX. Moreover, sVCAM-1 serum selevels have been associated to BPIX in both phases of the disorder. In addition, acute sVCAM-1 levels have been associted to GAF score in accute phase.

Conclusions

Our results suggest that cellular adhesion is an important factor in clinical presentation and overall severity of bipolar disorder.

Type
Article: 0462
Information
European Psychiatry , Volume 30 , Issue S1: Abstracts of the 23rd European Congress of Psychiatry , March 2015 , pp. 1
Copyright
Copyright © European Psychiatric Association 2015
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