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Verbal fluency as a possible predictor for psychosis

Published online by Cambridge University Press:  16 April 2020

H.E. Becker ,
D.H. Nieman ,
P.M. Dingemans ,
J.R. van de Fliert ,
L. De Haan  and
D.H. Linszen
H.E. Becker*
Affiliation:
Department of Psychiatry, Academic Medical Centre, Meibergdreef 5, 1105 AZAmsterdam, Netherlands
D.H. Nieman
Affiliation:
Department of Psychiatry, Academic Medical Centre, Meibergdreef 5, 1105 AZAmsterdam, Netherlands
P.M. Dingemans
Affiliation:
Department of Psychiatry, Academic Medical Centre, Meibergdreef 5, 1105 AZAmsterdam, Netherlands
J.R. van de Fliert
Affiliation:
Department of Psychiatry, Academic Medical Centre, Meibergdreef 5, 1105 AZAmsterdam, Netherlands
L. De Haan
Affiliation:
Department of Psychiatry, Academic Medical Centre, Meibergdreef 5, 1105 AZAmsterdam, Netherlands
D.H. Linszen
Affiliation:
Department of Psychiatry, Academic Medical Centre, Meibergdreef 5, 1105 AZAmsterdam, Netherlands
*
*Corresponding author: Tel.: +31 20 8913570; fax: +31 20 8913536. E-mail address: [email protected] (H.E. Becker).
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Abstract

Background

Neurocognitive abnormalities are prevalent in both first episode schizophrenia patients and in ultra high risk (UHR) patients.

Aim

To compare verbal fluency performance at baseline in UHR in patients that did and did not make the transition to psychosis.

Method

Baseline verbal fluency performance in UHR-patients (n = 47) was compared to match first episode patients (n = 69) and normal controls (n = 42).

Results

Verbal fluency (semantic category) scores in UHR-patients did not differ significantly from the score in first episode schizophrenia patients. Both the UHR group (p < 0.003) and the patient group (p < 0.0001) performed significantly worse than controls. Compared to the non-transition group, the transition group performed worse on verbal fluency, semantic category (p < 0.006) at baseline.

Conclusions

Verbal fluency (semantic category) is disturbed in UHR-patients that make the transition to psychosis and could contribute to an improved prediction of transition to psychosis in UHR-patients.

Keywords

Schizophrenia and psychosisUltra high riskNeuropsychologyTransition to psychosis
Type
Original articles
Information
European Psychiatry , Volume 25 , Issue 2 , March 2010 , pp. 105 - 110
Copyright
Copyright © Elsevier Masson SAS 2010

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