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Verapamil treatment in clozapine-induced sleep-related enuresis: a case report

Published online by Cambridge University Press:  16 April 2020

M Pojurovsky ,
M Schneidman ,
M Mark  and
A Weizman
M Pojurovsky
Affiliation:
Sha’ar Menashe Psychiatric Hospital, Hadera Tirat Camel Psychiatric Hospital, Haifa
M Schneidman
Affiliation:
Tirat Camel Psychiatric Hospital, Haifa
M Mark
Affiliation:
Mental Health Services, Israel Ministry of Health
A Weizman*
Affiliation:
Research Unit, Geha Psychiatric Hospital, and Felsenstein Medical Research Center, Beilinson Medical Center, PO Box 102, Sackler Faculty of Medicine, Tel Aviv University, Petah Tiqva49100, Israel
*
*Correspondence and reprints.
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Summary

Enuresis is an embarrassing rare side effect of clozapine treatment. Using single-blind placebo-control design, the antienuretic activity of the calcium channel blocker verapamil (up to 80 mg/day per os, at 21.00 hours) was evaluated in a schizophrenic patient with comorbid obsessive-compulsive disorder (OCD) who developed nocturnal functional enuresis during clozapine treatment. Verapamil (80 mg/day) displayed antienuretic activity. No correlation between the bradycardiac effect and the antienuretic activity of verapamil was detected.

Keywords

enuresisclozapineverapamil
Type
Case report
Information
European Psychiatry , Volume 10 , Issue 8 , 1995 , pp. 413 - 415
Copyright
Copyright © Elsevier, Paris 1995

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