Hostname: page-component-78c5997874-t5tsf Total loading time: 0 Render date: 2024-11-02T22:56:40.952Z Has data issue: false hasContentIssue false
  • English
  • Français

Structure and function of the corpus callosum in schizophrenia: What's the connection?

Published online by Cambridge University Press:  16 April 2020

AS David ,
C Minne ,
P Jones ,
I Harvey  and
MA Ron
AS David
Affiliation:
Department of Psychological Medicine, King's College Hospital and the Institute of Psychiatry, London
C Minne
Affiliation:
The Maudsley Hospital, London
P Jones
Affiliation:
Department of Psychological Medicine, King's College Hospital and the Institute of Psychiatry, London
I Harvey
Affiliation:
Department of Psychological Medicine, King's College Hospital and the Institute of Psychiatry, London The Institute of Neurology, Queen Square, London, UK
MA Ron
Affiliation:
The Institute of Neurology, Queen Square, London, UK
Get access

Summary

Tests of both structure and function of the corpus callosum have revealed abnormalities in schizophrenic patients. One such functional test employed lateralised Stroop stimuli presented tachistoscopically, to measure the transfer of interference and facilitation between the cerebral hemispheres. An attempt was made to relate indices of callosal transfer to clinical and demographic variables, including family history, as well as to indices of brain morphology. The latter included ventricle: brain ratio (VBR) measured by computed tomography (CT) scanning on 31 DSMIII schizophrenics, and the cross-sectional area of the corpus callosum from magnetic resonance imaging (MRI), obtained from 20 of these patients. VBR did not relate to functional measures; however, anterior callosal area correlated with indices of callosal connectivity. Patients with auditory hallucinations had smaller anterior callosal areas and tended to show less connectivity. The results show links between functional and structural measures of the corpus callosum, but their precise nature remains unclear.

Keywords

corpus callosummagnetic resonance imagingstroophallucinationsschizophrenia
Type
Original Articles
Information
European Psychiatry , Volume 10 , Issue 1 , 1995 , pp. 28 - 35
Copyright
Copyright © Elsevier, Paris 1995

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

American Psychiatric Association.Diagnostic and Statistical Manual of Mental Disorders, Revised Third Edition Washington DC: American Psychiatric Association, 1987Google Scholar
Annett, M.A classification of hand preference by association analysis. Br J Psychol. 1970;1: 303–2110.1111/j.2044-8295.1970.tb01248.xCrossRefGoogle Scholar
Barta, PEPearlson, GDPowers, RE et at. Auditory hallucinations and smaller superior temporal gyral volume in schizophrenia. Am J Psychiatry. 1990;147: 1457–62Google Scholar
Beaumont, JGDimond, SJBrain disconnection and schizophrenia. Br J Psychiatry. 1973;123: 661–210.1192/bjp.123.6.661CrossRefGoogle Scholar
Bech, PKastrup, MRafaelsen, OJMini-compendium of rating scales for states of anxiety, depression, mania and schizophienia with corresponding DSMIII syndromes. Acta Psychiatr Scand. 73suppl 3261986 32–7Google Scholar
Benson, DFZaidel, EThe Dual Brain. New York: Guilford Press, 1985Google Scholar
Bigelow, LBNasrallah, HARauscher, FPCorpus callosum thickness in chronic schizophrenia. Br J Psychiatry. 1983;142: 284–710.1192/bjp.142.3.284CrossRefGoogle ScholarPubMed
Casanova, MFSanders, RDGoldberg, TE et al. Morphometry of the corpus callosum in monozygotic twins discordant for schizophrenia: a magnetic resonance imaging study. J Neurol Neurosurg Psychiatry. 1990;53: 416–2110.1136/jnnp.53.5.416CrossRefGoogle ScholarPubMed
Clarke, JMLufkin, RBZaidel, ECorpus callosum morphometry and dichotic listening performance: individual differences in functional interhemispheric inhibition. Neuropsychologia. 1993;31: 547–5710.1016/0028-3932(93)90051-ZCrossRefGoogle ScholarPubMed
Clarke, SKraftsik, RVan, der Loos H et al. Forms and measures of adult and developing human corpus callosum: Is there sexual dimorphism?. J Comp Neurol. 1989;280: 213–3010.1002/cne.902800205CrossRefGoogle Scholar
Cleghorn, JMFranco, SSzechtman, BToward a brain map of auditory hallucinations. Am J Psychiatry. 1992;149: 1062–9Google Scholar
Coger, RWSerafetinides, EASchizophrenia, corpus callosum, and interhemispheric communication: a review. Psychiatry Res. 1990;34: 163–8410.1016/0165-1781(90)90017-YCrossRefGoogle ScholarPubMed
Cook, NDThe Brain Code: Mechanisms of Information Transfer and the Role of the Corpus Callosum. London: Methuen, 1986Google Scholar
David, ASTachistoscopic tests of colour naming and matching in schizophrenia: evidence for posterior callosum dysfunction?. Psychol Med. 1987;17: 621–3010.1017/S0033291700025861CrossRefGoogle ScholarPubMed
David, ASStroop interference within and between the cerebral hemispheres: studies in normals and acallosals. Neuropsychologia. 1992;30: 161–7510.1016/0028-3932(92)90025-HCrossRefGoogle ScholarPubMed
David, ASCallosal transfer in schizophrenia: too much or too little?. J Abnorm Psychol. 1993;102: 573–910.1037/0021-843X.102.4.573CrossRefGoogle ScholarPubMed
David, ASWacharasindhu, ALishman, WADevelopmental abnormalities of the corpus callosum and severe psychiatric disorders: review and case series. J Neurol Neurosurg Psychiatry. 1993;56: 85–9310.1136/jnnp.56.1.85CrossRefGoogle ScholarPubMed
DeLisi, LEHoff, ALSchwartz, JE et al. Brain morphology in first-episode schizophrenic-like psychotic patients: a quantitative magnetic resonance imaging study. Biol Psychiatry. 1991;29: 159–7510.1016/0006-3223(91)90044-MCrossRefGoogle ScholarPubMed
Demeter, SRingo, JLDoty, RWMorphometric analysis of the human corpus callosum and anterior commissure. Hum Neurobiol. 1988;6: 219–26Google ScholarPubMed
Doty, RWSchizophrenia: a disease of interhemispheric processes at forebrain and brainstem levels?. Behav Brain Res. 1989;34: 1–3310.1016/S0166-4328(89)80087-7CrossRefGoogle ScholarPubMed
Dyer, FNInterference and facilitation for color naming with separate bilateral presentations of the word and color. J Exp Psychol. 1973;99: 314–710.1037/h0035245CrossRefGoogle Scholar
Green, PHallet, SHunter, MAbnormal interhemispheric integration and hemisphere specialization in schizophrenics and high-risk children. In: JH, GruzelierP, FlorHenryLaterality and Psychopathology. Amsterdam: Elsevier Science Publishers, 1986 443–70Google Scholar
Günther, WPetsch, RSteinberg, R et al. Brain dysfunction during motor activation and corpus callosum alterations in schizophrenia measured by cerebral blood flow and magnetic resonance imaging. Biol Psychiatry. 1991;29: 535–5510.1016/0006-3223(91)90090-9CrossRefGoogle ScholarPubMed
Habib, MGayraud, DOliva, A et al. Effects of handedness and sex on the morphology of the corpus callosum: a study with brain magnetic resonance imaging. Brain Cognition. 1991;16: 41–6110.1016/0278-2626(91)90084-LCrossRefGoogle ScholarPubMed
Harvey, IMcGuffin, PWilliams, MToone, BKThe ventricle-brain ratio in functional psychoses: an admixture analysis. Psychiatr Res. 1990;35: 61–910.1016/0925-4927(90)90009-UCrossRefGoogle ScholarPubMed
Harvey, IRon, MAMurray, RLewis, SBarker, GMcManus, DMRI in schizophrenia: basal ganglia and white matter T1 times. Psychol Med. 1991;21: 587–9810.1017/S0033291700022224CrossRefGoogle ScholarPubMed
Harvey, IRon, MAdu, Boulay GWicks, DLewis, SWFeinstein, AMurray, RReduction of cortical volume in schizophrenia on magnetic resonance imaging. Psychol Med. 1992;23: 591–60410.1017/S003329170002537XCrossRefGoogle Scholar
Johnstone, ECCrow, TJFrith, CDHusband, JKreel, LCerebral ventricular size and cognitive impairment in chronic schizophrenia. Lancet. 1976;ii:924–610.1016/S0140-6736(76)90890-4CrossRefGoogle Scholar
MacLeod, CMHalf a century of research on the Stroop effect: an integrative review. Psychol Bull. 1991;109: 163–20310.1037/0033-2909.109.2.163CrossRefGoogle Scholar
McKeever, WFJackson, TLCerebral dominance assessed by object-and colour-naming latencies: sex and familial sinistrality effects. Brain Lang. 1979;7: 175–9010.1016/0093-934X(79)90015-4CrossRefGoogle Scholar
McManus, DGKermode, AGTofts, PSA repositioning technique for cerebral magnetic resonance imaging of patients with multiple sclerosis. Society of Magnetic Resonance in Medicine, abstracts (vol. 2) of the 8th annual meeting, Amsterdam, 1989 617Google Scholar
Nasrallah, HAThe unintegrated right cerebral hemispheric consciousness as alien intruder. Compr Psychiatry. 1985;26: 273–8210.1016/0010-440X(85)90072-0CrossRefGoogle ScholarPubMed
Nasrallah, HAAndreasen, NCCoffman, JAA controlled magnetic resonance imaging study of corpus callosum in schizophrenia. Biol Psychiatry. 1986;21: 274–8210.1016/0006-3223(86)90048-XCrossRefGoogle Scholar
Nelson, HEO'Connell, NADementia: the estimation of premorbid intelligence levels using the new adult reading test. Cortex. 1978 234–4410.1016/S0010-9452(78)80049-5CrossRefGoogle ScholarPubMed
Oepen, GFüngeld, MHöll, T et al. Schizophrenia —an emotional hypersensitivity of the right cerebral hemisphere. Int J Psychophysiol. 1987;5: 261–4CrossRefGoogle ScholarPubMed
O'Kusky, JStrauss, EKosaka, B et al. The corpus callosum is larger with right-hemisphere cerebral dominance. Ann Neurol. 1988;24: 379–8310.1002/ana.410240305CrossRefGoogle Scholar
Raine, AHarrison, GNReynolds, GP et al. Structural and functional characteristics of the corpus callosum in schizophrenics, psychiatric controls, and normal controls. Arch Gen Psychiatry. 1990;47: 1060–410.1001/archpsyc.1990.01810230076012CrossRefGoogle ScholarPubMed
Randall, PLSchizophrenia, abnormal connection and brain evolution. Med Hypotheses. 1983;10: 247–8010.1016/0306-9877(83)90114-7CrossRefGoogle ScholarPubMed
Robb, RABarillot, CInteractive display and analysis of 3-D medical images. IEEE Trans Med Imaging. 1989;8: 217–2610.1109/42.34710CrossRefGoogle ScholarPubMed
Rosenthal, RBigelow, LBQuantitative brain measures in chronic schizophrenia. Br J Psychiatry. 1972;121: 259–6410.1192/bjp.121.3.259CrossRefGoogle Scholar
Schneider, KClinical Psychopathology. New York: Grune and Stratton, 1959Google Scholar
Schwarzkopf, SBNasrallah, HAOlson, SCFamily history and brain morphology in schizophrenia: an MRI study. Psychiatr Res Neuroimaging. 1991;40: 49–6010.1016/0925-4927(91)90028-OCrossRefGoogle Scholar
Swayze, VWAndreasen, NCEhrhardt, JCYoh, WTCAlliger, RJCohen, GADevelopmental abnormalities of the corpus callosum in schizophrenia. Arch Neurol. 1990;47: 805–810.1001/archneur.1990.00530070103018CrossRefGoogle Scholar
Wing, JKCooper, JESartorius, NMeasurement and Classification of Psychiatric Symptoms. Cambridge: Cambridge University Press, 1974Google Scholar
Uematsu, MKaiya, HThe morphology of the corpus callosum in schizophrenia. An MRI study. Schizophr Res. 1988;1: 391–810.1016/0920-9964(88)90020-5CrossRefGoogle ScholarPubMed
Witelson, SFHand and sex differences in the isthmus and genu of the human corpus callosum: a postmortem morphological study. Brain. 1989;112: 799–83510.1093/brain/112.3.799CrossRefGoogle ScholarPubMed
Woodruff, PWRPearlson, GDGeer, MJBarta, PEChilcoat, HDA computerized magnetic resonance imaging of corpus callosum morphology in schizophrenia. Psychol Med. 1993;23: 45–5610.1017/S0033291700038836CrossRefGoogle Scholar
Young, AWMethodological and theoretical bases. In: Beaumont, JGDivided Visual Field Studies of Cerebral Organisation. London: Academic Press, 1982Google Scholar
Zaidel, EClarke, JMSuyenobu, BHemispheric independence: a paradigm case for cognitive neuroscience. In: Scheibel, AWeschler, ANeurobiology of Higher Cognitive Functioning. New York: Guilford Press, 1990Google Scholar
Submit a response

Comments

No Comments have been published for this article.