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Self-rated residual symptoms do not predict 1-year recurrence of depression

Published online by Cambridge University Press:  16 April 2020

G. Bertschy ,
E. Haffen ,
N. Gervasoni ,
M. Gex-Fabry ,
C. Osiek ,
D. Marra ,
J.-M. Aubry  and
G. Bondolfi
G. Bertschy*
Affiliation:
Division of adult psychiatry, Department of psychiatry, University Hospitals of Geneva, 2, chemin du Petit-Bel-Air, 1225Chêne-Bourg, Geneva, Switzerland
E. Haffen
Affiliation:
Division of adult psychiatry, University Hospital of Besançon, boulevard Fleming, 25030Besançon, France
N. Gervasoni
Affiliation:
Academic department of psychiatry, University of Geneva and Clinique la Métairie, avenue Bois-Bougy, 1260Nyon, Switzerland
M. Gex-Fabry
Affiliation:
Division of adult psychiatry, Department of psychiatry, University Hospitals of Geneva, 2, chemin du Petit-Bel-Air, 1225Chêne-Bourg, Geneva, Switzerland
C. Osiek
Affiliation:
Division of adult psychiatry, Department of psychiatry, University Hospitals of Geneva, 2, chemin du Petit-Bel-Air, 1225Chêne-Bourg, Geneva, Switzerland
D. Marra
Affiliation:
Division of adult psychiatry, Pitié-Salpêtrière Hospital, 47, boulevard de l’Hôpital, 75634Paris cedex 13, France
J.-M. Aubry
Affiliation:
Division of adult psychiatry, Department of psychiatry, University Hospitals of Geneva, 6–8, rue du 31-Décembre, 1207Geneva, Switzerland
G. Bondolfi
Affiliation:
Division of adult psychiatry, Department of psychiatry, University Hospitals of Geneva, 6–8, rue du 31-Décembre, 1207Geneva, Switzerland
*
*Corresponding author. Tel.: +41 22 305 47 01; fax: +41 22 305 47 69. E-mail address: [email protected] (G. Bertschy).
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Abstract

Background

Residual depressive symptoms are generally documented as a risk factor for recurrence. In the absence of a specific instrument for the assessment of residual symptoms, a new 25-item Depression Residual Symptom Scale (DRSS) was elaborated and tested for recurrence prediction over a 1-year follow-up.

Sampling and methods

Fifty-nine patients in remission after a major depressive episode (MDE) were recruited in two centres. They were assessed with the DRSS and the Montgomery-Asberg Depression Rating Scale (MADRS) at inclusion and followed for 1 year according to a seminaturalistic design. The DRSS included specific depressive symptoms and subjective symptoms of vulnerability, lack of return to usual self and premorbid level of functioning.

Results

Severity of residual symptoms was not significantly associated with increased risk of recurrence. However, DRSS score was significantly higher among patients with three or more episodes than one to two episodes. Number of previous episodes and treatment interruption were not identified as significant predictors of recurrence.

Conclusion

The proposed instrument is not predictive of depressive recurrence, but is sensitive to increased perception of vulnerability associated with consecutive episodes. Limitations include small sample size, seminaturalistic design (no standardisation of treatment) and content of the instrument.

Keywords

DepressionRecurrenceRating scaleRemissionRisk factors
Type
Original articles
Information
European Psychiatry , Volume 25 , Issue 1 , January 2010 , pp. 52 - 57
Copyright
Copyright © Elsevier Masson SAS 2010

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Footnotes

*

This study was supported in part by a grant of the Swiss National Science Foundation (Grant No. 32-64112.00 to Jean-Michel Aubry, Guido Bondolfi and Gilles Bertschy).

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