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Repeated ketamine administration redeems the time lag for citalopram's antidepressant-like effects

Published online by Cambridge University Press:  15 April 2020

G.-F. Zhang ,
W.-X. Liu ,
L.-L. Qiu ,
J. Guo ,
X.-M. Wang ,
H.-L. Sun ,
J.-J. Yang  and
Z.-Q. Zhou
G.-F. Zhang
Affiliation:
Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing210002, China
W.-X. Liu
Affiliation:
Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing210002, China
L.-L. Qiu
Affiliation:
Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing210002, China
J. Guo
Affiliation:
Department of Anesthesiology, Affiliated Hospital of Nanjing, University of Traditional Chinese Medicine, Nanjing, China
X.-M. Wang
Affiliation:
Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing210002, China
H.-L. Sun
Affiliation:
Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing210002, China
J.-J. Yang*
Affiliation:
Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing210002, China Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical College, Xuzhou, China Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou, China
Z.-Q. Zhou*
Affiliation:
Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing210002, China
*
⁎⁎Co-corresponding author. Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, China. E-mail addresses:[email protected] (J.-J. Yang)
*Corresponding author. Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, China. Tel.: +86 25 52323834; fax: +86 25 84806839. E-mail addresses:[email protected] (Z.-Q. Zhou).
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Abstract

Current available antidepressants exhibit low remission rate with a long response lag time. Growing evidence has demonstrated acute sub-anesthetic dose of ketamine exerts rapid, robust, and lasting antidepressant effects. However, a long term use of ketamine tends to elicit its adverse reactions. The present study aimed to investigate the antidepressant-like effects of intermittent and consecutive administrations of ketamine on chronic unpredictable mild stress (CUMS) rats, and to determine whether ketamine can redeem the time lag for treatment response of classic antidepressants. The behavioral responses were assessed by the sucrose preference test, forced swimming test, and open field test. In the first stage of experiments, all the four treatment regimens of ketamine (10 mg/kg ip, once daily for 3 or 7 consecutive days, or once every 7 or 3 days, in a total 21 days) showed robust antidepressant-like effects, with no significant influence on locomotor activity and stereotype behavior in the CUMS rats. The intermittent administration regimens produced longer antidepressant-like effects than the consecutive administration regimens and the administration every 7 days presented similar antidepressant-like effects with less administration times compared with the administration every 3 days. In the second stage of experiments, the combination of ketamine (10 mg/kg ip, once every 7 days) and citalopram (20 mg/kg po, once daily) for 21 days caused more rapid and sustained antidepressant-like effects than citalopram administered alone. In summary, repeated sub-anesthestic doses of ketamine can redeem the time lag for the antidepressant-like effects of citalopram, suggesting the combination of ketamine and classic antidepressants is a promising regimen for depression with quick onset time and stable and lasting effects.

Keywords

DepressionKetamineCitalopramBehavior
Type
Original article
Information
European Psychiatry , Volume 30 , Issue 4 , June 2015 , pp. 504 - 510
Copyright
Copyright © Elsevier Masson SAS 2015

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Footnotes

1

The two authors contributed equally to this work.

References

aan het Rot, M, Collins, KA, Murrough, JW, Perez, AM, Reich, DL, Charney, DSet al.Safety and efficacy of repeated-dose intravenous ketamine for treatment-resistant depression. Biol Psychiatry 2009;67(2):139–145.CrossRefGoogle Scholar
Adler, CM, Malhotra, AK, Elman, I, Goldberg, T, Egan, M, Pickar, Det al.Comparison of ketamine-induced thought disorder in healthy volunteers and thought disorder in schizophrenia. Am J Psychiatry 1999;156(10):1646–1049.CrossRefGoogle Scholar
Araya-Callís, C, Hiemke, C, Abumaria, N, Flugge, GChronic psychosocial stress and citalopram modulate the expression of the glian proteins GFAP and NDRG2 in the hippocampus. Psychopharmacology (Berl) 2012;224(1):209–222.CrossRefGoogle Scholar
Autry, AE, Adachi, M, Nosyreva, E, Na, ES, Los, MF, Cheng, PFet al.NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses. Nature 2011;475(7354):91–95.CrossRefGoogle ScholarPubMed
Bergman, SAKetamine: review of its pharmacology and its use in pediatric anesthesia. Anesth Prog 1999;46(1):10–20.Google ScholarPubMed
Berman, RM, Cappiello, A, Anand, A, Oren, DA, Heninger, GR, Charney, DSet al.Antidepressant effects of ketamine in depressed patients. Biol Psychiatry 2000;47(4):351–354.CrossRefGoogle ScholarPubMed
Beurel, E, Song, L, Jope, RSInhibition of glycogen synthase kinase-3 is necessary for the rapid antidepressant effect of ketamine in mice. Mol Psychiatry 2011;16(11):1068–1070.CrossRefGoogle ScholarPubMed
Browne, CA, Lucki, IAntidepressant effects of ketamine: mechanisms underlying fast-acting novel antidepressants. Front Pharmacol 2013;4:161.CrossRefGoogle ScholarPubMed
Chaviaras, S, Mak, P, Ralph, D, Krishnan, L, Broadbear, JHAssessing the antidepressant-like effects of carbetocin, an oxytocin agonist, using a modification of the forced swimming test. Psychopharmacology (Berl) 2010;210(1):35–43.CrossRefGoogle ScholarPubMed
Cornwell, BR, Salvadore, G, Furey, M, Marquardt, CA, Brutsche, NE, Grillon, Cet al.Synaptic potentiation is critical for rapid antidepressant response to ketamine in treatment-resistant major depression. Biol Psychiatry 2012;72(7):555–561.CrossRefGoogle ScholarPubMed
de Oliveira, L, Fraga, DB, De Luca, RD, Canever, L, Ghedim, FV, Matos, MPet al.Behavioral changes and mitochondrial dysfunction in a rat model of schizophrenia induced by ketamine. Metab Brain Dis 2011;26(1):69–77.CrossRefGoogle Scholar
Garcia, LS, Comim, CM, Valvassori, SS, Réus, GZ, Stertz, L, Kapczinski, Fet al.Ketamine treatment reverses behavioral and physiological alterations induced by chronic mild stress in rats. Prog Neuropsychopharmacol Biol Psychiatry 2009;33(3):450–455.CrossRefGoogle ScholarPubMed
Gigliucci, V, O’Dowd, G, Casey, S, Egan, D, Gibney, S, Harkin, AKetamine elicits sustained antidepressant-like activity via a serotonin-dependent mechanism. Psychopharmacology (Berl) 2013;228(1):157–166.CrossRefGoogle Scholar
Huang, NK, Wan, FJ, Tseng, CJ, Tung, CSAmphetamine induces hydroxyl radical formation in the striatum of rats. Life Sci 1997;61(22):2219–2229.CrossRefGoogle ScholarPubMed
Ibrahim, L, Diaz Granados, N, Jolkovsky, L, Brutsche, N, Luckenbaugh, DA, Herring, WJet al.A Randomized, placebo-controlled, crossover pilot trial of the oral selective NR2B antagonist MK-0657 in patients with treatment-resistant major depressive disorder. J Clin Psychopharmacol 2012;32(4):551–557.CrossRefGoogle ScholarPubMed
Judd, LL, Akiskal, HS, Schettler, PJ, Endicott, J, Maser, J, Solomon, DAet al.The long-term natural history of the weekly symptomatic status of bipolar I disorder. Arch Gen Psychiatry 2002;59(6):530–537.CrossRefGoogle ScholarPubMed
Kim, H, Chen, L, Lim, G, Sung, B, Wang, S, McCabe, MFet al.Brain indoleamine 2,3-dioxygenase contributes to the comorbidity of pain and depression. J Clin Invest 2012;122(8):2940–2954.CrossRefGoogle ScholarPubMed
Krishnan, V, Nestler, EJAnimal models of depression: molecular perspectives. Curr Top Behav Neurosci 2011;7:121–147.CrossRefGoogle ScholarPubMed
Lapmanee, S, Charoenphandhu, J, Charoenphandhu, NBeneficial effects of fluoxetine, reboxetine, venlafaxine, and voluntary running exercise in stressed male rats with anxiety-and depression-like behaviors. Behav Brain Res 2013;250:316–325.CrossRefGoogle ScholarPubMed
Li, N, Lee, B, Liu, RJ, Banasr, M, Dwyer, JM, Iwata, Met al.mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists. Science 2010;329(5994):959–964.CrossRefGoogle ScholarPubMed
Li, N, Liu, RJ, Dwyer, JM, Banasr, M, Lee, B, Son, Het al.Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure. Biol Psychiatry 2011;69(8):754–761.CrossRefGoogle ScholarPubMed
Liu, Q, Yu, J, Mao-Ying, QL, Mi, WL, Li, B, Wang, YQet al.Repeated clomipramine treatment reversed the inhibition of cell proliferation in adult hippocampus induced bychronic unpredictable stress. Pharmacogenomics J 2008;8(6):375–383.CrossRefGoogle Scholar
Ma, XC, Dang, YH, Jia, M, Ma, R, Wang, F, Wu, Jet al.Long-lasting antidepressant action of ketamine, but not glycogen synthase kinase-3 inhibitor SB216763, in the chronic mild stress model of mice. PLoS One 2013;8(2):e56053.CrossRefGoogle Scholar
Maeng, S, Zarate, CA Jr., Du, J, Schloesser, RJ, McCammon, J, Chen, Get al.Cellular mechanisms underlying the antidepressant effects of ketamine: role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors. Biol Psychiatry 2008;63(4):349–352.CrossRefGoogle ScholarPubMed
Monteggia, LM, Gideons, E, Kavalali, ETThe role of eukaryotic elongation factor 2 kinase in rapid antidepressant action of ketamine. Biol Psychiatry 2013;73(12):1199–1203.CrossRefGoogle ScholarPubMed
Murrough, JW, Iosifescu, DV, Chang, LC, Al Jurdi, RK, Green, CE, Perez, AMet al.Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial. Am J Psychiatry 2013;170(10):1134–1142.CrossRefGoogle ScholarPubMed
Murrough, JW, Perez, AM, Pillemer, S, Stern, J, Parides, MK, aan het Rot, Met al.Rapid and longer-term antidepressant effects of repeated ketamine infusions in treatment-resistant major depression. Biol Psychiatry 2013;74(4):250–256.CrossRefGoogle ScholarPubMed
Nakajima, S, Suzuki, T, Watanabe, K, Kashima, H, Uchida, HAccelerating response to antidepressant treatment in depression: a review and clinical suggestions. Prog Neuropsychopharmacol Biol Psychiatry 2010;34(2):259–264.CrossRefGoogle ScholarPubMed
Nishitani, N, Nagayasu, K, Asaoka, N, Yamashiro, M, Shirakawa, H, Nakagawa, Tet al.Raphe AMPA receptors and nicotinic acetylcholine receptors mediate ketamine-induced serotonin release in the rat prefrontal cortex. Int J Neuropsychopharmacol 2014;17(8):1321–1326.CrossRefGoogle ScholarPubMed
Owolabi, RA, Akanmu, MA, Adeyemi, OIEffects of ketamine and N-methyl-d-aspartate on fluoxetine-induced antidepressant-related behavior using the forced swimming test. Neurosci Lett 2014;566:172–176.CrossRefGoogle ScholarPubMed
Parise, EM, Alcantara, LF, Warren, BL, Wright, KN, Hadad, R, Sial, OKet al.Repeated ketamine exposure induces an enduring resilient phenotype in adolescent and adult rats. Biol Psychiatry 2013;74(10):750–759.CrossRefGoogle ScholarPubMed
Perry, EB Jr., Cramer, JA, Cho, HS, Petrakis, IL, Karper, LP, Genovese, Aet al.Psychiatric safety of ketamine in psychopharmacology research. Psychopharmacology 2007;192(2):253–260.CrossRefGoogle ScholarPubMed
Preskorn, SH, Baker, B, Kolluri, S, Menniti, FS, Krams, M, Landen, JWAn innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-D-aspartate antagonist. CP-101,606, in patients ithtreatment-refractory majord epressive disorder. J Clin Psychopharmacol 2008;28(6):631–637.CrossRefGoogle Scholar
Rushforth, SL, Steckler, T, Shoaib, MNicotine improves working memory span capacity in rats following sub-chronic ketamine exposure. Neuropsychopharmacology 2011;36(13):2774–2781.CrossRefGoogle ScholarPubMed
Shiroma, PR, Johns, B, Kuskowski, M, Wels, J, Thuras, P, Albott, CSet al.Augmentation of response and remission to serial intravenous; subanesthetic ketamine in treatment resistant depression. J Affect Disord 2014;155:123–129.CrossRefGoogle ScholarPubMed
Skolnick, P, Popik, P, Trullas, RGlutamate-based antidepressants: 20 years on. Trends Pharmacol Sci 2009;30(11):563–569.CrossRefGoogle Scholar
Szymkowicz, SM, Finnegan, N, DaleR, MA 12-month naturalistic observation of three patients receiving repeat intravenous ketamine infusions for their treatment-resistant depression. J Affect Disord 2013;147(1–3):416–420.CrossRefGoogle ScholarPubMed
Thase, ME, Haight, BR, Richard, N, Rockett, CB, Mitton, M, Modell, JGet al.Remission rates following antidepressant therapy with bupropion or selective serotonin reuptake inhibitors: a meta-analysis of original data from 7 randomized controlled trials. J Clin Psychiatry 2005;66(8):974–981.CrossRefGoogle ScholarPubMed
Tokita, K, Yamaji, T, Hashimoto, KRoles of glutamate signaling in preclinical and/or mechanistic models of depression. Pharmacol Biochem Behav 2012;100(4):688–704.CrossRefGoogle ScholarPubMed
Tomiya, M, Fukushima, T, Kawai, J, Aoyama, C, Mitsuhashi, S, Santa, Tet al.Alterations of plasma and cerebrospinal fluid glutamate levels in rats treated with the N-methyl-D-aspartate receptor antagonist, ketamine. Biomed Chromatogr 2006;20(6–7):628–633.CrossRefGoogle ScholarPubMed
Trivedi, MH, Rush, AJ, Wisniewski, SR, Nierenberg, AA, Warden, D, Ritz, Let al.Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice. Am J Psychiatry 2006;163(1):28–40.CrossRefGoogle ScholarPubMed
Wang, X, Yang, Y, Zhou, X, Wu, J, Li, J, Jiang, Xet al.Propofol pretreatment increases antidepressant-like effects induced by acute administration of ketamine in rats receiving forced swimming test. Psychiatry Res 2011;185(1–2):248–253.CrossRefGoogle ScholarPubMed
Yang, J, Pei, Y, Pan, YL, Jia, J, Shi, C, Yu, Yet al.Enhanced antidepressant-like effects of electroacupuncture combined with citalopram in a rat model of depression. Evid Based Complement Alternat Med 2013;2013:107380.Google Scholar
Zarate, CA Jr., Singh, JB, Carlson, PJ, Brutsche, NE, Ameli, R, Luckenbaugh, Aet al.A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression. Arch Gen Psychiatry 2006;63(8):856–864.CrossRefGoogle ScholarPubMed
Zarate, CA Jr., Brutsche, NE, Ibrahim, L, Franco-Chaves, J, Diazgranados, N, Cravchik, Aet al.Replication of ketamine's antidepressant efficacy in bipolar depression: a randomized controlled add-on trial. Biol Psychiatry 2012;71(11):939–946.CrossRefGoogle ScholarPubMed
Zhang, GF, Wang, N, Shi, JY, Xu, SX, Li, XM, Ji, MHet al.Inhibition of L-arginine-nitric oxide pathway mediates the antidepressant effects of ketamine on rats in the forced swimming test. Pharmacol Biochem Behav 2013;110:8–12.CrossRefGoogle ScholarPubMed
Zhou, Z, Zhang, G, Li, X, Liu, X, Wang, N, Qiu, Let al.Loss of phenotype of parvalbumin interneurons in rat prefrontal cortex is involved in antidepressant- and propsychotic-like behaviors following acute and repeated ketamine administration. Mol Neurobiol 2014 [Epub ahead of print].Google ScholarPubMed
Zuo, DY, Wu, YL, Yao, WX, Cao, Y, Wu, CF, Tanaka, MEffect of MK-801 and ketamine on hydroxyl radical generation in the posterior cingulate and retrosplenial cortex of free-moving mice, as determined by in vivo microdialysis. Pharmacol Biochem Behav 2007;86(1):1–7.CrossRefGoogle ScholarPubMed
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