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Psychosocial functioning in patients with treatment resistant depression

Published online by Cambridge University Press:  16 April 2020

Timothy Petersen ,
George I. Papakostas ,
Yasmin Mahal ,
Wendy M. Guyker ,
Erin C. Beaumont ,
Jonathan E. Alpert ,
Maurizio Fava  and
Andrew A. Nierenberg
Timothy Petersen*
Affiliation:
Department of Psychiatry, Depression Clinical and Research Program, Massachusetts General Hospital, 15 Parkman Street, WAC 812Boston, MA 02114, USA
George I. Papakostas
Affiliation:
Department of Psychiatry, Depression Clinical and Research Program, Massachusetts General Hospital, 15 Parkman Street, WAC 812Boston, MA 02114, USA
Yasmin Mahal
Affiliation:
Department of Psychiatry, Depression Clinical and Research Program, Massachusetts General Hospital, 15 Parkman Street, WAC 812Boston, MA 02114, USA
Wendy M. Guyker
Affiliation:
Department of Psychiatry, Depression Clinical and Research Program, Massachusetts General Hospital, 15 Parkman Street, WAC 812Boston, MA 02114, USA
Erin C. Beaumont
Affiliation:
Department of Psychiatry, Depression Clinical and Research Program, Massachusetts General Hospital, 15 Parkman Street, WAC 812Boston, MA 02114, USA
Jonathan E. Alpert
Affiliation:
Department of Psychiatry, Depression Clinical and Research Program, Massachusetts General Hospital, 15 Parkman Street, WAC 812Boston, MA 02114, USA
Maurizio Fava
Affiliation:
Department of Psychiatry, Depression Clinical and Research Program, Massachusetts General Hospital, 15 Parkman Street, WAC 812Boston, MA 02114, USA
Andrew A. Nierenberg
Affiliation:
Department of Psychiatry, Depression Clinical and Research Program, Massachusetts General Hospital, 15 Parkman Street, WAC 812Boston, MA 02114, USA
*
*Corresponding author. [email protected] (T. Petersen).
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Abstract

Background

Depression is a disorder that causes disability, with a profound adverse impact on all areas of psychosocial functioning. This is particularly true for those with treatment resistant depression (TRD). However, to date, no systematic assessments of psychosocial functioning for patients with TRD have been conducted.

Methods

In the present study, we used the Longitudinal Interval Follow-up Evaluation (LIFE) scale to measure psychosocial functioning in 92 patients with TRD. These patients met formal criteria for TRD and were part of a clinical trial examining the efficacy of lithium augmentation of nortriptyline.

Results

Clinicians rated this sample of patients as experiencing mild to moderate impairment in work-related activities, good to fair interpersonal relations, poor level of involvement in recreational activities, and mild impairment of ability to enjoy sexual activity. Patients and clinicians rated global social adjustment as poor.

Conclusions

Patients with formally defined TRD experience significant impairment in psychosocial functioning. In this sample a tendency existed for both clinicians and patients to assign more severely impaired global ratings when compared with ratings for specific functional areas.

Keywords

Treatment resistant depressionPsychosocial functioning
Type
Original article
Information
European Psychiatry , Volume 19 , Issue 4 , June 2004 , pp. 196 - 201
Copyright
Copyright © European Psychiatric Association 2002

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