Hostname: page-component-586b7cd67f-tf8b9 Total loading time: 0 Render date: 2024-11-28T00:06:43.511Z Has data issue: false hasContentIssue false
  • English
  • Français

Psychosis-proneness correlates with expression levels of dopaminergic genes

Published online by Cambridge University Press:  15 April 2020

P. Grant ,
F. Gabriel ,
Y. Kuepper ,
C. Wielpuetz  and
J. Hennig
P. Grant*
Affiliation:
Center for Psychobiology and Behavioral Medicine, Justus-Liebig-University Giessen, Otto-Behaghel-Str. 10F, 35394Giessen, Germany
F. Gabriel
Affiliation:
Center for Psychobiology and Behavioral Medicine, Justus-Liebig-University Giessen, Otto-Behaghel-Str. 10F, 35394Giessen, Germany
Y. Kuepper
Affiliation:
Center for Psychobiology and Behavioral Medicine, Justus-Liebig-University Giessen, Otto-Behaghel-Str. 10F, 35394Giessen, Germany
C. Wielpuetz
Affiliation:
Center for Psychobiology and Behavioral Medicine, Justus-Liebig-University Giessen, Otto-Behaghel-Str. 10F, 35394Giessen, Germany
J. Hennig
Affiliation:
Center for Psychobiology and Behavioral Medicine, Justus-Liebig-University Giessen, Otto-Behaghel-Str. 10F, 35394Giessen, Germany
*
*Corresponding author. Tel.: +496419926155; fax: +496419926159. E-mail address:[email protected] (P. Grant).
Get access

Abstract

Psychosis-proneness or schizotypy is a personality organisation mirroring individual risk for schizophrenia-development. Believed to be a fully dimensional construct sharing considerable geno- and phenotypal variance with clinical schizophrenia, it has become an increasingly promising tool for basic psychosis-research. Although many studies show genetic commonalities between schizotypy and schizophrenia, changes in regulation of gene expression have never been examined in schizotypy before. We therefore extracted RNA from the blood, a valid surrogate for brain tissue, of a large sample of 67 healthy male volunteers and correlated the activities of all genes relevant for dopaminergic neurotransmission with the positive schizotypy-scale of the O-LIFE. We found significant negative correlations regarding the expression of the genes COMT, MAOB, DRD4, DRD5 and FOS, indicating that increased schizotypy coincides with higher levels of dopaminergic dysregulation on the mRNA-level. Considering the advantages of this method, we suggest that it be applied more often in fundamental psychosis-research.

Keywords

Schizophrenia and psychosisMolecular biologyPsychosis pronenessSchizotypyGene expressionEndophenotype
Type
Short Communications
Information
European Psychiatry , Volume 29 , Issue 5 , June 2014 , pp. 304 - 306
Copyright
Copyright © Elsevier Masson SAS 2014

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

☆

These data were, in part, presented at the 2013-meeting of the International Society for the Study of Individual Differences.

References

Avramopoulos, D., Stefanis, N.C., Hantoumi, I., Smyrnis, N., Evdokimidis, I., Stefanis, C.N.Higher scores of self reported schizotypy in healthy young males carrying the COMT high activity allele. Mol Psychiatry 2002;7(7):706–711. http://dx.doi.org/10.1038/sj.mp.4001070.CrossRefGoogle ScholarPubMed
Claridge, G.Theoretical background and issues. In: Claridge, G.Schizotypy – Implications for Illness and Health 1st ed.Oxford, New York, Tokyo: Oxford University Press; 1997. p. 3–18.CrossRefGoogle Scholar
de Jong, S., Boks, M.P., Fuller, T.F., Strengman, E., Janson, E., de Kovel, C.G.A gene co-expression network in whole blood of schizophrenia patients is independent of antipsychotic-use and enriched for brain-expressed genes. PLoS One 2012;7(6):e39498 [doi:http://doi:10.1371/journal.pone.0039498 PONE-D-11-16822[pii]].CrossRefGoogle ScholarPubMed
Ettinger, U., Corr, P.J., Mofidi, A., Williams, S.C., Kumari, V.Dopaminergic basis of the psychosis-prone personality investigated with functional magnetic resonance imaging of procedural learning. Front Hum Neurosci 2013;7:130 [http://doi:10.3389/fnhum.2013.00130].CrossRefGoogle ScholarPubMed
Glatt, S.J., Everall, I.P., Kremen, W.S., Corbeil, J., Sasik, R., Khanlou, N.Comparative gene expression analysis of blood and brain provides concurrent validation of SELENBP1 up-regulation in schizophrenia. Proc Natl Acad Sci U S A 2005;102(43):15533–15538 [http://doi:0507666102 [pii]10.1073/pnas.0507666102].CrossRefGoogle Scholar
Grant, P.Letter to the Editor: haloperidol but not dopamine rapidly induces neuronal death: comments on “A systematic review of the effects of antipsychotic drugs on brain volume”. Psychol Med 2013;43(07):1568 [http://doi:S0033291713001001 [pii] 10.1017/S0033291713001001].CrossRefGoogle Scholar
Grant, P., Kuepper, Y., Mueller, E., Wielpuetz, C., Mason, O., Hennig, J.Dopaminergic foundations of schizotypy as measured by the German version of the Oxford-Liverpool Inventory of Feelings and Experiences (O-LIFE) – a suitable endophenotype of schizophrenia. Front Hum Neurosci 2013;7(1): [http://doi:10.3389/fnhum.2013.00001].CrossRefGoogle ScholarPubMed
Grazioplene, R.G., Chavez, R.S., DeYoung, C.G.Disconnected Minds, Open Minds: white matter correlates of high Openness support a dimensional model of psychosis. Paper presented at the ISSID 2013, Barcelona 2013.Google Scholar
Harrison, P.J., Weinberger, D.R.Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol Psychiatry 2005;10(1):40–48 [image 45. http://doi:10.1038/sj.mp.4001558 4001558 [pii]].CrossRefGoogle ScholarPubMed
Hemby, S.E., Ginsberg, S.D., Brunk, B., Arnold, S.E., Trojanowski, J.Q., Eberwine, J.H.Gene expression profile for schizophrenia: discrete neuron transcription patterns in the entorhinal cortex. Arch Gen Psychiatry 2002;59(7):631–640 [http://doi:yoa20032 [pii]].CrossRefGoogle ScholarPubMed
Howes, O.D., Kapur, S.The dopamine hypothesis of schizophrenia: version III. The final common pathway. Schizophr Bull 2009;35(3):549–562 [http://doi:10.1093/schbul/sbp006].CrossRefGoogle ScholarPubMed
Iwamoto, K., Kato, T.Gene expression profiling in schizophrenia and related mental disorders. Neuroscientist 2006;12(4):349–361 [http://doi:12/4/349 [pii] 10.1177/1073858406287536].CrossRefGoogle ScholarPubMed
Lenzenweger, M.F.Schizotypy – an organizing framework for schizophrenia research. Curr Dir Psychol Sci 2006;15(4):162–166 [http://doi:10.1111/j.1467-8721.2006.00428.x].CrossRefGoogle Scholar
Macare, C., Woestmann, N.M., Aichert, D.S., Meindl, T., Ettinger, U.The Schizotypal Brain – An fMRI Antisaccade Task Study. Paper presented at the ISSID 2013, Barcelona 2013.Google Scholar
Mason, O., Claridge, G.The Oxford-Liverpool Inventory of Feelings and Experiences (O-LIFE): further description and extended norms. Schizophr Res 2006;82(2–3):203–211 [http://doi:10.1016/j.schres.2005.12.845].CrossRefGoogle ScholarPubMed
Maycox, P.R., Kelly, F., Taylor, A., Bates, S., Reid, J., Logendra, R.Analysis of gene expression in two large schizophrenia cohorts identifies multiple changes associated with nerve terminal function. Mol Psychiatry 2009;14(12):1083–1094 [http://doi:mp200918[pii]10.1038/mp.2009.18].CrossRefGoogle ScholarPubMed
Sheldrick, A.J., Krug, A., Markov, V., Leube, D., Michel, T.M., Zerres, K.Effect of COMT val(158)met genotype on cognition and personality. Eur Psychiatry 2008;23(6):385–389. http://dx.doi.org/10.1016/j.eurpsy.2008.05.002.CrossRefGoogle Scholar
Smyrnis, N., Avramopoulos, D., Evdokimidis, I., Stefanis, C.N., Tsekou, H., Stefanis, N.C.Effect of schizotypy on cognitive performance and its tuning by COMT val(158) met genotype variations in a large population of young men. Biol Psychiatry 2007;61(7):845–853http://dx.doi.org/10.1016/j.biopsych.2006.07.019.CrossRefGoogle Scholar
Supplementary material: Image

Grant et al. supplementary material

Supplementary materials

Download Grant et al. supplementary material(Image)
Image 659.1 KB
Supplementary material: File

Grant et al. supplementary material

Supplementary materials

Download Grant et al. supplementary material(File)
File 38.9 KB
Supplementary material: File

Grant et al. supplementary material

Table S1

Download Grant et al. supplementary material(File)
File 44.5 KB
Submit a response

Comments

No Comments have been published for this article.