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Psychiatric symptoms and cognitive dysfunction caused by Epstein–Barr virus-induced encephalitis

Published online by Cambridge University Press:  16 April 2020

Joachim Behr M.D. ,
Martin Schaefer M.D. ,
Eckhard Littmann Ph.D. ,
Randolf Klingebiel M.D.  and
Andreas Heinz M.D.
Joachim Behr M.D.*
Affiliation:
Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Campus Charite Mitte, Schumannstr. 20/21, 10117Berlin, Germany Neuroscience Research Center, Charite University Medicine Berlin, Campus Charite Mitte, Schumannstr. 20/21, 10117Berlin, Germany
Martin Schaefer M.D.
Affiliation:
Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Campus Charite Mitte, Schumannstr. 20/21, 10117Berlin, Germany
Eckhard Littmann Ph.D.
Affiliation:
Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Campus Charite Mitte, Schumannstr. 20/21, 10117Berlin, Germany
Randolf Klingebiel M.D.
Affiliation:
Department of Radiology, Charite University Medicine Berlin, Campus Charite Mitte, Schumannstr. 20/21, 10117Berlin, Germany
Andreas Heinz M.D.
Affiliation:
Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Campus Charite Mitte, Schumannstr. 20/21, 10117Berlin, Germany
*
*Corresponding author. Tel.: +49 30 450 539031; fax: +49 30 450 539941. E-mail address: [email protected] (J. Behr).
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Abstract

Epstein-Barr virus (EBV) encephalitis is rare and shows a wide range of clinical manifestations. We report an immunocompromised patient with EBV encephalitis diagnosed by EBV-specific PCR and antibody testing in the cerebrospinal fluid who presented with psychiatric symptoms and cognitive dysfunction in the absence of any neurological impairments or infectious signs. Clinical recovery and clearance of cerebrospinal fluid EBV DNA appeared following ganciclovir treatment within 6 weeks.

Keywords

Epstein–Barr virusPsychiatric symptomsCognitive dysfunctionEncephalitisBone marrow transplantationGanciclovir
Type
Case-report
Information
European Psychiatry , Volume 21 , Issue 8 , December 2006 , pp. 521 - 522
Copyright
Copyright © Elsevier Masson SAS 2006

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