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Persistent cerebellar deterioration in a patient with lobar pneumonia under lithium, carbamazepine, and trifluperidol treatment

Published online by Cambridge University Press:  16 April 2020

F Bischof ,
A Melms  and
M Fetter
F Bischof
Affiliation:
Department of Immunology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands
A Melms
Affiliation:
Department of Neurology, University of Tübingen, Tübingen, Germany
M Fetter
Affiliation:
Department of Neurology, University of Tübingen, Tübingen, Germany
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Summary

We report on a patient with schizoaffective disorder who was on combination therapy of lithium, carbamazepine, and the neuroleptic trifluperidol. He experienced a lobar pneumonia and developed an acute and persistent cerebellar deterioration which was most likely due to lithium toxicity, while the serum lithium level was within the therapeutic range. The combination of lithium, carbamazepine, and neuroleptics is common, and is generally considered to be safe. The reported case suggests that this regimen might increase the risk of intoxication with potentially disabling side-effects.

Keywords

affective disordercarbamazepinecerebellumlithiumneurolepticstoxicity
Type
Case Reports
Information
European Psychiatry , Volume 14 , Issue 3 , June 1999 , pp. 175 - 176
Copyright
Copyright © European Psychiatric Association 1999

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