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Pain modulation role of melatonin in eating disorders

Published online by Cambridge University Press:  16 April 2020

H. Papezová ,
A. Yamamotová  and
J. Nedvídková
H. Papezová*
Affiliation:
Department of Psychiatry, 1st Faculty of Medicine, Charles University Prague, Ke Karlovu 11, 12821Prague 2, Czech Republic
A. Yamamotová
Affiliation:
Department of Normal, Pathological and Clinical Physiology, 3rd Faculty of Medicine, Charles University Prague, Prague, Czech Republic
J. Nedvídková
Affiliation:
Institute of Endocrinology, Prague, Czech Republic
*
*Correspondence and reprints. E-mail address: [email protected] (H. Papezová).
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Abstract

The objective of this study was to test the effect of melatonin on thermal pain threshold in female patients with eating disorders. Fourteen patients were included in the study. We found a parabolic relation between pain threshold and the content of urine sulfatoxymelatonin (r = 0.6299, P < 0.05). We can speculate that increase in severity of eating disorder pathology may decrease both the melatonin level and pain sensitivity. In contrast with expected melatonin analgesic effect, our results showed its possible normalizing influence as well on pathologically decreased pain sensitivity.

Type
Short communication
Information
European Psychiatry , Volume 16 , Issue 1 , February 2001 , pp. 68 - 70
Copyright
Copyright © Éditions scientifiques et médicales Elsevier SAS.

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