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Interventions to improve adherence to antipsychotic medication in patients with schizophrenia–A review of the past decade

Published online by Cambridge University Press:  15 April 2020

E. Barkhof ,
C.J. Meijer ,
L.M.J. de Sonneville ,
D.H. Linszen  and
L. de Haan
E. Barkhof*
Affiliation:
Department of Psychiatry, Academic Medical Centre, Meibergdreef 5, 1105AZAmsterdam, The Netherlands
C.J. Meijer
Affiliation:
Department of Psychiatry, Academic Medical Centre, Meibergdreef 5, 1105AZAmsterdam, The Netherlands
L.M.J. de Sonneville
Affiliation:
Department of Clinical Child and Adolescent Studies, Leiden University, Leiden, The Netherlands
D.H. Linszen
Affiliation:
Department of Psychiatry, Academic Medical Centre, Meibergdreef 5, 1105AZAmsterdam, The Netherlands
L. de Haan
Affiliation:
Department of Psychiatry, Academic Medical Centre, Meibergdreef 5, 1105AZAmsterdam, The Netherlands
*
* Corresponding author. Tel.: +31 20 8913500; fax: +31 20 8913702. E-mail address:[email protected] (E. Barkhof).
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Abstract

Objective

Nonadherence to antipsychotic medication is highly prevalent in patients with schizophrenia and has a deleterious impact on the course of the illness. This review seeks to determine the interventions that were examined in the past decade to improve adherence rates.

Method

The literature between 2000 and 2009 was searched for randomized controlled trials which compared a psychosocial intervention with another intervention or with treatment as usual in patients with schizophrenia.

Results

Fifteen studies were identified, with a large heterogeneity in design, adherence measures and outcome variables. Interventions that offered more sessions during a longer period of time, and especially those with a continuous focus on adherence, seem most likely to be successful, as well as pragmatic interventions that focus on attention and memory problems. The positive effects of adapted forms of Motivational Interviewing found in earlier studies, such as compliance therapy, have not been confirmed.

Conclusion

Nonadherence remains a challenging problem in schizophrenia. The heterogeneity of factors related to nonadherence calls for individually tailored approaches to promote adherence. More evidence is required to determine the effects of specific interventions.

Keywords

AdherenceAntipsychoticsIntervention studiesReview of the literatureSchizophrenia
Type
Review
Information
European Psychiatry , Volume 27 , Issue 1 , January 2012 , pp. 9 - 18
Copyright
Copyright © Elsevier Masson SAS 2012

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References

Agarwal, MRSharma, VKKishore Kumar, KVLowe, DNon-compliance with treatment in patients suffering from schizophrenia: a study to evaluate possible contributing factors. Int J Soc Psychiatry. 1998; 44(2): 92–10610.1177/002076409804400202CrossRefGoogle ScholarPubMed
Atkinson, JMCoia, DAGilmour, WH, et al.The impact of education groups for people with schizophrenia on social functioning and quality of life. Br J Psychiatry. 1996;168:199–20410.1192/bjp.168.2.199CrossRefGoogle ScholarPubMed
Azrin, NHTeichner, GEvaluation of an instructional program for improving medication compliance for chronically mentally ill outpatients. Behav Res Ther. 1998;36:849–86110.1016/S0005-7967(98)00036-9CrossRefGoogle ScholarPubMed
Battle, EHHalliburton, AWallston, KASelf-medication among psychiatric patients and adherence after discharge. J Psychosoc Nurs Ment Health Serv. 1982;20:21–28Google ScholarPubMed
Becker, MHMaimon, LASociobehavioural determinants of compliance with health and medical care recommendations. Med Care. 1975;13:10–2410.1097/00005650-197501000-00002CrossRefGoogle Scholar
Beebe, LHSmith, KCrye, C, et al.Telenursing intervention increases psychiatric medication adherence in schizophrenia outpatients. J Am Psychiatr Nurses Assoc. 2008; 14(3): 217–22410.1177/1078390308318750CrossRefGoogle ScholarPubMed
Bigelow, DAMcFarland, BHGareau, MJYoung, DJImplementation and effectiveness of a bed reduction project. Community Ment Health J. 1991;27:125–13310.1007/BF00752815CrossRefGoogle Scholar
Boczkowski, JAZeichner, ADeSanto, NNeuroleptic compliance among chronic schizophrenic outpatients: an intervention outcome report. J Consult Clin Psychiatry. 1985;53:666–67110.1037/0022-006X.53.5.666CrossRefGoogle ScholarPubMed
Bond, GRMiller, LDKrumwied, RDWard, RSAssertive case management in three CMHCs: a controlled study. Hosp Community Psychiatry. 1988;39:411–418Google ScholarPubMed
Bond, GRWitheridge, TFWasmer, D, et al.A comparison of two crisis housing alternatives to psychiatric hospitalization. Hosp Community Psychiatry. 1989;40:177–183Google ScholarPubMed
Bond, GRMcDonel, ECMiller, LDPensec, MAssertive community treatment and reference groups: an evaluation of their effectiveness for young adults with serious mental illness and substance abuse problems. Psychosoc Rehabil J. 1991;15:30–43Google Scholar
Brown, CSWright, RGChristensen, DBAssociation between type of medication instruction and patients’ knowledge, side effects, and compliance. Hosp Community Psychiatry. 1987;38:55–60Google ScholarPubMed
Buchanan, AA two-year prospective study of treatment compliance in patients with schizophrenia. Psychol Med. 1992; 22(3): 787–79710.1017/S0033291700038228CrossRefGoogle ScholarPubMed
Buchkremer, GKlingberg, SHolle, RSchulze Monking, HHornung, WPPsychoeducational psychotherapy for schizophrenic patients and their key relatives or caregivers: results of a 2-year follow-up. Acta Psychiatr Scand. 1997;96:483–49110.1111/j.1600-0447.1997.tb09951.xCrossRefGoogle ScholarPubMed
Buckley, PFCorrel, CUStrategies for dosing and switching antipsychotics for optimal clinical management. J Clin Psychiatry. 2008; 67(S1): 17–Google Scholar
Bush, CTLangford, MWRosen, PGott, WOperation outreach: intensive case management for severely psychiatrically disabled adults. Hosp Community Psychiatry. 1990;41:647–649Google ScholarPubMed
Byerly, MJThompson, ACarmody, T, et al.Validity of electronically monitored medication adherence and conventional adherence measures in schizophrenia. Psychiatr Serv. 2007;58:844–84710.1176/ps.2007.58.6.844CrossRefGoogle Scholar
Chan, SWYip, BTso, SCheng, BSTam, WEvaluation of a psychoeducation program for Chinese clients with schizophrenia and their family caregivers. Patient Educ Couns. 2009; 75(1): 67–7610.1016/j.pec.2008.08.028CrossRefGoogle ScholarPubMed
Chien, WTChan, SWThompson, DREffects of a mutual support group for families of Chinese people with schizophrenia: 18-month follow-up. Br J Psychiatry. 2006;189:41–4910.1192/bjp.bp.105.008375CrossRefGoogle ScholarPubMed
Claassen, DFakhoury, WKFord, RPriebe, SMoney for medication: financial incentives to improve medication adherence in assertive outreach. Psychiatr Bull. 2007;31:4–710.1192/pb.31.1.4CrossRefGoogle Scholar
Connor, JRafter, NRodgers, ADo fixed-dose combination pills or unit-of-packaging improve adherence? A systematic review. Bull World Health Organ. 2004;82:935–939Google ScholarPubMed
Cramer, JARosenheck, RCompliance with medical regimes for mental and physical disorders. Psychiatr Serv. 1998;49:196–20110.1176/ps.49.2.196CrossRefGoogle Scholar
De Haan, LLavalaye, Jvan Bruggen, M, et al.Subjective experience and dopamine D2 receptor occupancy in patients treated with antipsychotics: clinical implications. Can J Psychiatry. 2004; 49(5): 290–296CrossRefGoogle ScholarPubMed
Diaz, ENeuse, ESullivan, MCPearsall, HRWoods, SWAdherence to conventional and atypical antipsychotics after hospital discharge. J Clin Psychiatry. 2004; 65(3): 354–36010.4088/JCP.v65n0311CrossRefGoogle ScholarPubMed
Dixon, LWeiden, PTorres, MLehman, AAssertive community treatment and medication compliance in the homeless mentally ill. Am J Psychiatry. 1997;154:1302–1304Google ScholarPubMed
Dolder, CRLacro, JPLeckband, SJeste, DVInterventions to improve antipsychotic medication adherence: review of recent literature. J Clin Psychopharmacol. 2003; 23(4): 389–399CrossRefGoogle ScholarPubMed
Eckman, TALiberman, RPPhipps, CCTeaching medication management skills to schizophrenic patients. J Clin Psychopharmacol. 1990;10:33–3810.1097/00004714-199002000-00006CrossRefGoogle ScholarPubMed
Elvevåg, BMaylor, EAGilbert, ALHabitual prospective memory in schizophrenia. BMC Psychiatry. 2003;3:910.1186/1471-244X-3-9CrossRefGoogle Scholar
Falloon, IRMcGill, CWBoyd, JLPederson, JFamily management in the prevention of morbidity of schizophrenia. Arch Gen Psychiatry. 1985;42:887–89610.1001/archpsyc.1985.01790320059008CrossRefGoogle ScholarPubMed
Fenton, WSBlyler, CRHeinssen, RKDeterminants of medication compliance in schizophrenia: empirical and clinical findings. Schizophr Bull. 1997; 23(4): 637–65110.1093/schbul/23.4.637CrossRefGoogle ScholarPubMed
Ford, RBeadsmore, ARyan, PRepper, JCraig, TMuijen, MProviding the safety net: case management for people with serious mental illness. J Ment Health. 1995;1:91–9710.1080/09638239550037893CrossRefGoogle Scholar
Frank, AFGunderson, JGThe role of the therapeutic alliance in the treatment of schizophrenia. Relationship to course and outcome. Arch Gen Psychiatry. 1990; 47(3): 228–23610.1001/archpsyc.1990.01810150028006CrossRefGoogle ScholarPubMed
Gilbert, PLHarris, MJMcAdams, LAJeste, DVNeuroleptic withdrawal in schizophrenic patients: a review of the literature. Arch Gen Psychiatry. 1995; 52(3): 173–18810.1001/archpsyc.1995.03950150005001CrossRefGoogle ScholarPubMed
Glick, IDClarkin, JFHaas, GLSpencer, JHA randomized clinical trial of inpatient family intervention. VI: mediating variables and outcome. Fam Process. 1991;30:85–9910.1111/j.1545-5300.1991.00085.xCrossRefGoogle ScholarPubMed
Gray, RDoes patients education enhance compliance with clozapine? A preliminary investigation. J Psychiatr Ment Health Nurs. 2000;7:285–286CrossRefGoogle ScholarPubMed
Gray, RWykes, TEdmonds, MLeese, MGournay, KEffect of a medication management training package for nurses on clinical outcomes for patients with schizophrenia: cluster randomised controlled trial. Br J Psychiatry.. 2004;185:157–162CrossRefGoogle ScholarPubMed
Gray, RLeese, MBindman, J, et al.Adherence therapy for people with schizophrenia. European multicentre randomised controlled trial. Br J Psychiatry. 2006;189:508–514CrossRefGoogle ScholarPubMed
Greenberg, RNOverview of patient compliance with medication dosing: a literature review. Clin Ther. 1984; 6(5): 592–599Google ScholarPubMed
Giuffrida, ATorgerson, DJShould we pay the patient? Review of financial incentives to enhance patient compliance. BMJ. 1997; 315(7110): 703–707CrossRefGoogle ScholarPubMed
Guimon, LEguiluz, IBulbena, AGroup pharmacotherapy in schizophrenics: attitudinal and clinical changes. Eur J Psychiatry. 1993;7:147–154Google Scholar
Harris, NLovell, KDay, JRoberts, CAn evaluation of a medication management training programme for community mental health professionals; service user level outcomes. A cluster randomised controlled trial. Int J Nurs Stud. 2008;46:645–652CrossRefGoogle ScholarPubMed
Hayward, PChan, NKemp, R, et al.Medication self-management: a preliminary report on an intervention to improve medication compliance. J Ment Health. 1995;4:511–517CrossRefGoogle Scholar
Herz, MIPsychosocial treatment. Psychiatr Ann. 1996;26:531–535CrossRefGoogle Scholar
Hogarty, GEAnderson, CMReiss, DJ, et al.Family psychoeducation, social skills training, and maintenance chemotherapy in the aftercare treatment of schizophrenia, I: one-year effects of a controlled study on relapse and expressed emotion. Arch Gen Psychiatry. 1986;43:633–642CrossRefGoogle Scholar
Hogarty, GEAnderson, CMReiss, DJ, et al.Family psychoeducation, social skills training, and maintenance chemotherapy in the aftercare treatment of schizophrenia, II: two-year effects of a controlled study on relapse and adjustment. Arch Gen Psychiatry. 1991;48:340–347CrossRefGoogle Scholar
Hogarty, GEKornblith, SJGreenwald, D, et al.Three-year trials of personal therapy among schizophrenic patients living with or independent of family. I: description of study and effects on relapse rates. Am J Psychiatry. 1997;154:1504–1513CrossRefGoogle ScholarPubMed
Hornung, WPKieserg, AFeldmann, RBuchkremer, GPsychoeducational training for schizophrenic patients: background, procedure and empirical findings. Patient Educ Couns. 1996;29:257–268CrossRefGoogle ScholarPubMed
Hornung, WPKlingberg, SFeldmann, RSchonauer, KSchulze Monking, HCollaboration with drug treatment by schizophrenic patients with and without psychoeducational training: results of a 1-year follow-up. Acta Psychiatr Scand. 1998;97:213–21910.1111/j.1600-0447.1998.tb09990.xCrossRefGoogle ScholarPubMed
Hudson, TJOwen, RRThrush, CR, et al.Guideline implementation and patient-tailoring strategies to improve medication adherence for schizophrenia. J Clin Psychiatry. 2008;69:74–80CrossRefGoogle Scholar
Jeste, SDPatterson, TLPalmer, BWDolder, CRGoldman, SJeste, DVCognitive predictors of medication adherence among middle-aged and older outpatients with schizophrenia. Schizophr Res. 2003; 63(1–2–): 49–58CrossRefGoogle ScholarPubMed
Kashner, TMRader, LERodell, DEBeck, CMRodell, LRMuller, KFamily characteristics, substance abuse, and hospitalization patterns of patients with schizophrenia. Hosp Community Psychiatry. 1991;42:195–197Google ScholarPubMed
Kelly, GRScott, JAMedication compliance and health education among outpatients with chronic mental disorders. Med Care. 1990;28:1181–1197CrossRefGoogle ScholarPubMed
Kemp, RHayward, PApplewhaite, GEveritt, BDavid, ACompliance therapy in psychotic patients: randomised controlled trial. BMJ. 1996; 312(10): 345–34910.1136/bmj.312.7027.345CrossRefGoogle ScholarPubMed
Kemp, RKirov, GEveritt, BHayward, PDavid, ARandomised controlled trial of compliance therapy: 18-month follow-up. Br J Psychiatry. 1998;172:413–419CrossRefGoogle ScholarPubMed
Klingberg, SSchneider, SWittorf, ABuchkremer, GWiedemann, GCollaboration in outpatient antipsychotic drug treatment: analysis of potentially influencing factors. Psychiatry Res. 2008; 161(2): 225–23410.1016/j.psychres.2007.07.027CrossRefGoogle ScholarPubMed
Lacro, JPDunn, LBDolder, CRLeckband, SGJeste, DVPrevalence of and risk factors for medication nonadherence in patients with schizophrenia: a comprehensive review of recent literature. J Clin Psychiatry. 2002; 63(10): 892–909CrossRefGoogle ScholarPubMed
Leff, JKuipers, LBerkowitz, RSturgeon, DA controlled trial of social interventions in the families of schizophrenia patients: two-year follow-up. Br J Psychiatry. 1985;146:594–600CrossRefGoogle Scholar
Leff, JBerkowitz, RShavit, NStrachan, AGlass, IVaughn, CA trial of family therapy versus a relatives group for schizophrenia. Br J Psychiatry. 1989;154:58–66CrossRefGoogle Scholar
Leff, JBerkowitz, RShavit, NStrachan, AGlass, IVaughn, CA trial of family therapy versus a relatives group for schizophrenia: two-year follow-up. Br J Psychiatry. 1990;157:571–577CrossRefGoogle Scholar
Lehman, AFKreyenbuhl, JBuchanan, RW, et al.The Schizophrenia Patient Outcomes Research Team (PORT): updated treatment recommendations 2003. Schizophr Bull. 2004; 30(2): 193–21710.1093/oxfordjournals.schbul.a007071CrossRefGoogle ScholarPubMed
Leucht, SBarnes, TRKissling, WEngel, RRCorrell, CKane, JMRelapse prevention in schizophrenia with new-generation antipsychotics: a systematic review and exploratory meta-analysis of randomized, controlled trials. Am J Psychiatry. 2003; 160(7): 1209–1222CrossRefGoogle ScholarPubMed
Leucht, SHeres, SEpidemiology, clinical consequences, and psychosocial treatment of nonadherence in schizophrenia. J Clin Psychiatry. 2006; 67(S5): 3–8Google Scholar
Li, ZArthur, DFamily education for people with schizophrenia in Beijing, China. Br J Psychiatry. 2005;187:339–345CrossRefGoogle ScholarPubMed
Lindenmayer, JPLiu-Seifert, HKulkarni, PM, et al.Medication nonadherence and treatment outcome in patients with schizophrenia or schizoaffective disorder with sub-optimal prior response. J Clin Psychiatry. 2009; 70(7): 990–996CrossRefGoogle ScholarPubMed
Linszen, DDingemans, PVan Der Does, JW, et al.Treatment, expressed emotion, and relapse in recent onset schizophrenic disorders. Psychol Med. 1996;26:333–342CrossRefGoogle ScholarPubMed
McEvoy, JPFreter, SEverett, G, et al.Insight and the clinical outcome of schizophrenic patients. J Nerv Ment Dis. 1989; 177(1): 48–51CrossRefGoogle ScholarPubMed
McFarlane, WRLukens, ELink, B, et al.Multiple-family groups and psychoeducation in the treatment of schizophrenia. Arch Gen Psychiatry. 1995;52:679–687CrossRefGoogle ScholarPubMed
Macpherson, RJerrom, BHughes, AA controlled study of education about drug treatment in schizophrenia. Br J Psychiatry. 1996;168:709–717CrossRefGoogle Scholar
Malm, UThe influence of group therapy on schizophrenia. Acta Psychiatr Scand. 297Suppl.1982 1–6510.1111/j.1600-0447.1982.tb00288.xCrossRefGoogle ScholarPubMed
Maneesakorn, SRobson, DGournay, K, et al.An RCT of adherence therapy for people with schizophrenia in Chiang Mai, Thailand. J Clin Nurs. 2007;16:1302–1312CrossRefGoogle ScholarPubMed
Merinder, LBViuff, AGLaugesen, HDClemmensen, KMisfelt, SEspensen, BPatient and relative education in community psychiatry: a randomized controlled trial regarding its effectiveness. Soc Psychiatry Psychiatr Epidemiol. 1999;34:287–294CrossRefGoogle ScholarPubMed
Miller, WRRollnick, SMotivational interviewing: preparing people for change. New York: Guilford Press; 2002.Google Scholar
Modrcin, MRapp, CAPoertner, JThe evaluation of case management services with the chronically mentally ill. Eval Program Plann 1988; 11: 307–314CrossRefGoogle ScholarPubMed
Möller, HJClinical evaluation of negative symptoms in schizophrenia. Eur Psychiatry 2007; 22: 380–386CrossRefGoogle Scholar
Morken, GGrawe, RWWiden, JHEffects of an integrated treatment on antipsychotic medication adherence in a randomized trial in recent-onset schizophrenia. J Clin Psychiatry 2007;68(4):566–571CrossRefGoogle Scholar
Newcomer, JWHaupt, DWThe metabolic effects of antipsychotic medications. Can J Psych 2006; 51: 480–491CrossRefGoogle ScholarPubMed
O’Donnell, CDonohoe, GSharkey, L, et al.Compliance therapy: a randoimised cotrolled trail in schizophrenia. BMJ 2003;327(7419):834CrossRefGoogle Scholar
Perkins, DOAdherence to antipsychotic medications. J Clin Psychiatry 60Suppl. 211999 25–30Google ScholarPubMed
Petersen, LJeppesen, PThorup, AAbel, MBØhlenschlaeger, J, et al.A randomised multicentre trial of integrated versus standard treatment for patients with a first episode of psychotic illness. BMJ 2005;331(7517):602CrossRefGoogle ScholarPubMed
Pijnenborg, GHWithaar, FKBrouwer, WHTimmerman, MEvan den Bosch, RJEvans, JJThe efficacy of SMS text messages to compensate for the effects of cognitive impairments in schizophrenia. Br J Clin Psychol 2009 [Epub].Google Scholar
Priebe, SBurton, AAshby, D, et al.Financial incentives to improve adherence to anti-psychotic maintenance medication in non-adherent patients – a cluster randomised controlled trial (FIAT). BMC Psychiatry 2009;9:61CrossRefGoogle ScholarPubMed
Ran, MSXiang, MZChan, CL, et al.Effectiveness of psychoeducational intervention for rural Chinese families experiencing schizophrenia-a randomised controlled trial. Soc Psychiatry Psychiatr Epidemiol 2003;38(2):69–75CrossRefGoogle ScholarPubMed
Razali, MSYahya, HCompliance with treatment in schizophrenia: a drug intervention program in a developing country. Acta Psychiatr Scand 1995; 91: 331–33510.1111/j.1600-0447.1995.tb09790.xCrossRefGoogle Scholar
Razali, SMHasanah, CIKhan, ASubramaniam, MPsychosocial interventions for schizophrenia. J Ment Health 2000; 9: 283–28910.1080/713680246CrossRefGoogle Scholar
Remington, GJAdams, MEDepot neuroleptic therapy: clinical considerations. Can J Psychiatry 403 Suppl. 11995 S5–S11Google ScholarPubMed
Robinson, DWoerner, MAlvir, J, et al.Predictors of relapse following response from a first episode of schizophrenia or schizoaffective disorder. Arch Gen Psychiatry 1999; 56: 241–247CrossRefGoogle ScholarPubMed
Robinson, DGWoerner, MGAlvir, JMBilder, RMHinrichsen, GALieberman, JAPredictors of medication discontinuation by patients with first episode schizophrenia and schizoaffective disorder. Schizophr Res 2002; 57: 209–219CrossRefGoogle ScholarPubMed
Sands, RGCnaan, RATwo models of case management: assessing their impact. Community Ment Health J 1994; 30: 441–457CrossRefGoogle Scholar
Schooler, NRKeith, SJSevere, JB, et al.Relapse and rehospitalization during maintenance treatment of schizophrenia: the effects of dose reduction and family treatment. Arch Gen Psychiatry 1997; 54: 453–463CrossRefGoogle ScholarPubMed
Schooler, NRRelapse and rehospitalization: comparing oral and depot antipsychotics. J Clin Psychiatry 64Suppl. 162003 14–17Google ScholarPubMed
Seltzer, ARoncar, IGarfinkel, PEffect of patient education on medication compliance. Can J Psychiatry 1980; 25: 638–645CrossRefGoogle ScholarPubMed
Solomon, PDraine, JThe efficacy of a consumer case management team: 2-year outcomes of a randomized trial. J Ment Health Adm 1995; 22: 135–146CrossRefGoogle ScholarPubMed
Spaniel, FVohlídka, PHrdlicka, J, et al.ITAREPS: information technology aided relapse prevention programme in schizophrenia. Schizophr Res 2008; 98: 312–317CrossRefGoogle Scholar
Stein, LITest, MAAlternative to mental hospital treatment. I: conceptual model, treatment program, and clinical evaluation. Arch Gen Psychiatry 1980; 37: 392–397CrossRefGoogle ScholarPubMed
Strang, JSFalloon, IRMoss, HBRazani, JBoyd, JLThe effects of family therapy on treatment compliance in schizophrenia. Psychopharmacol Bull 1981; 17: 87–88Google Scholar
Streicker, SKAmdur, MDincin, JEducating patients about psychiatric medications: failure to enhance compliance. Psychosoc Rehabil J 1986; 4: 15–28Google Scholar
Tarrier, NThe community management of schizophrenia: a controlled trial of a behavioural intervention with families to reduce relapse. Br J Psychiatry 1988; 153: 532–542CrossRefGoogle ScholarPubMed
Telles, CKarno, MMintz, J, et al.Immigrant families coping with schizophrenia: behavioural family intervention v case management with a low-income Spanish-speaking population. Br J Psychiatry 1995; 167: 473–479CrossRefGoogle ScholarPubMed
Turner, EHMatthews, AMEftihia Linardatos, E, et al.Selective publication of antidepressant trials and its onfluence on apparent Efficay. N Eng J Med 2008; 358: 252–260CrossRefGoogle Scholar
Uzenoff, SRPerkins, DOHamer, RMWiesen, CAPenn, DLA preliminary trial of adherence-coping-education (ACE) therapy for early psychosis. J Nerv Ment Dis 2008; 196: 572–575CrossRefGoogle ScholarPubMed
Valenstein, MKavanagh, JLee, Tet al. Using a pharmacy-based intervention to improve antispychotic adherence among patients with serious mental illness. Schizophr Bull 2009 [Epub Nov 21:1–10].Google Scholar
Van Putten, PWhy do schizophrenic patients refuse to take their drugs?. Arch Gen Psychiatry 1974; 31: 67–72CrossRefGoogle ScholarPubMed
Van Putten, TCrumpton, EYale, CDrug refusal in schizophrenia and the wish to be crazy. Arch Gen Psychiatry 1976;33(12):1443–1446CrossRefGoogle ScholarPubMed
Velligan, DILam, YWGlahn, DC, et al.Defining and assessing adherence to oral antipsychotics: a review of the literature. Schizophr Bull 2006; 32: 724–742CrossRefGoogle ScholarPubMed
Velligan, DIWang, MDiamond, P, et al.Relationships among subjective and objective measures of adherence to oral antipsychotic medications. Psychiatr Serv 2007;58(9):1187–1192CrossRefGoogle ScholarPubMed
Velligan, DIDiamond, PMMintz, J, et al.The use of individually tailored environmental supports to improve medication adherence and outcomes in schizophrenia. Schizophr Bull 2008;34(3):483–493CrossRefGoogle Scholar
Velligan, DIWeiden, PJSajatovic, M, et al.The expert consensus guideline series: adherence problems in patients with serious and persistent mental illness. J Clin Psychiatry 70Suppl. 42009 1–46Google ScholarPubMed
Weiden, PJShaw, EMann, JCauses of neuroleptic noncompliance. Psychiatr Ann 1986; 16: 571–575CrossRefGoogle Scholar
Weiden, PIOlfson, MCost of relapse in schizophrenia. Schizophr Bull 1995; 21: 419–429CrossRefGoogle Scholar
Weiden, PJKozma, CGrogg, ALocklear, JPartial compliance and risk of rehospitalization among California Medicaid patients with schizophrenia. J Psychiatr Serv 2004;55(8):886–89110.1176/appi.ps.55.8.886CrossRefGoogle ScholarPubMed
Xiang, MRan, MLi, SA controlled evaluation of psychoeducational family intervention in a rural Chinese community. Br J Psychiatry 1994; 165: 544–548CrossRefGoogle Scholar
Xiong, WPhillips, MRXiong, H, et al.Family-based intervention for schizophrenic patients in China: a randomised controlled trial. Br J Psychiatry 1994; 165: 239–247CrossRefGoogle ScholarPubMed
Young, JLZonana, HVShepler, LMedication noncompliance in schizophrenia: codification and update. Bull Am Acad Psychiatry Law 1986; 14: 105–122Google ScholarPubMed
Zhang, MWang, MLi, JPhillips, MRRandomised-control trial of family intervention for 78 first-episode male schizophrenic patients: an 18-month study in Suzhou, Jiangsu. Br J Psychiatry Suppl 1994; 24: 96–102CrossRefGoogle Scholar
Zygmunt, AOlfson, MBoyer, CAMechanic, DInterventions to improve medication adherence in schizophrenia. Am J Psychiatry 2002;159(10):1653–1664CrossRefGoogle Scholar
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