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Increased serum drug concentrations in concomitant treatment with citalopram, clomipramine and alprazolam

Published online by Cambridge University Press:  16 April 2020

U Lepola ,
E Leinonen  and
H Koponen
U Lepola
Affiliation:
Psychiatric Research Clinic of Kuopio, Asemakatu 46 B, SF-70110Kuopio
E Leinonen
Affiliation:
Psychiatric Research Clinic of Kuopio, Asemakatu 46 B, SF-70110Kuopio
H Koponen
Affiliation:
Moisio Hospital, Mikkeli, Finland
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Summary

We report the case of a patient with major depression and obsessive-compulsive disorder who had simultaneously high serum citalopram, clomipramine, and alprazolam concentrations probably due to the reciprocal competitive inhibition of the cytochrome P450-catalyzed oxidative metabolism.

Keywords

alprazolamcitalopramclomipraminecytochrome P450drug interaction
Type
Case report
Information
European Psychiatry , Volume 9 , Issue 6 , 1994 , pp. 312 - 314
Copyright
Copyright © European Psychiatric Association 1994

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References

Antal, EJEreshefsky, LWells, BEvans, RLRichards, ALTownsend, RJSmith, RBMulti-center evaluation of the kinetic and clinical interaction of alprazolam and imipramine Clin Pharmacol Ther 1986;39:178Google Scholar
Brosen, KCytochrom P450 gen-superfamiliens betydning for laegemidlers kliniske farmakokinetik Ugeskr Laeg 1991;153: 417-22Google Scholar
Brosen, KIsozyme specific drug oxidation: genetic polymorphism and drug-drug interactions Nord J Psychiatry 1993:47 (suppl 30):21-6CrossRefGoogle Scholar
Crewe, HKLennard, MSTucker, GTWoods, FRHaddock, REThe effect of selective serotonin re-uptake inhibitors on cytochrome P4502D6 (CYP2D6) activity in human liver microsomes Br J Clin Pharmacol 1992;34: 262-5CrossRefGoogle ScholarPubMed
Fredricsson-Overo, K The Role of Pharmacokinetics in the Development of New Drugs: an Illustration by Studies on Citalopram. Department of Biochemistry. H Lundbeck A/S, Copenhagen. Thesis, 1986Google Scholar
Goodman, WKMcDougle, CJPrice, LHPharmacotherapy of obsessive-compulsive disorder J Clin Psychiatry 1992;53 (suppl 4):29-37Google ScholarPubMed
Greenblatt, DJvon Moltke, LLHarmatz, JSCiraulo, DAShader, RIAlprazolam pharmacokinetics, metabolism, and plasma levels: clinical implications J Clin Psychiatry 1993;54 (suppl 10):4-11Google ScholarPubMed
Lin, WFrade, PSimultaneous quantification of eight tricyclic antidepressants in serum by high performance liquid chromatography Ther Drux Monit 1987;9: 448-55CrossRefGoogle Scholar
Montgomery, SAThe place of obsessive compulsive disorder in the diagnostic hierarchy Int Clin Psychopharmacol 1992;7 (suppl 1): 19–23CrossRefGoogle ScholarPubMed
Preskorn, SHSimpson, STricyclic antidepressant-induced delirium and plasma drug concentrations Am J Psychiatry 1982; 139:822-3Google Scholar
Zohar, JZohar-Kadouch, RCKindler, SCurrent concepts in the pharmacological treatment of obsessive compulsive disorder Drugs 1992;43: 210-8CrossRefGoogle ScholarPubMed
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