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In vivo hippocampal 31P NMR metabolites in Alzheimer's disease and ageing

Published online by Cambridge University Press:  16 April 2020

G Mecheri ,
M Marie-Cardine ,
D Sappey-Marinier ,
H Bonmartin ,
G Albrand ,
G Ferry ,
N Coppard-Meyer  and
P Courpron
G Mecheri
Affiliation:
Lyon RTH Laënnec Medical School, Claude Bernard University and CHS, Le Vinatier, 95 bd Pinel (jeune equipe 1882 - J Dalery), 69677Bron cedex, France
M Marie-Cardine
Affiliation:
Lyon RTH Laënnec Medical School, Claude Bernard University and CHS, Le Vinatier, 95 bd Pinel (jeune equipe 1882 - J Dalery), 69677Bron cedex, France
D Sappey-Marinier
Affiliation:
Lyon-Sud Medical School, Claude-Bernard University and CHLS Jules-Courmont, Pierre-Bénite, France
H Bonmartin
Affiliation:
Lyon-Sud Medical School, Claude-Bernard University and CHLS Jules-Courmont, Pierre-Bénite, France
G Albrand
Affiliation:
Antoine-Charrial Hospital, Francheville, France
G Ferry
Affiliation:
Geriatric Medicine Unit, Les Aurélias, Craponne, France
N Coppard-Meyer
Affiliation:
Geriatric Medicine Unit, Les Aurélias, Craponne, France
P Courpron
Affiliation:
Antoine-Charrial Hospital, Francheville, France
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Summary

Memory loss is the most common early symptom of Alzheimer's disease (AD). For this study, we chose the hippocampi as regions of interest. The hippocampus, which is closely associated with memory processing, is known to be vulnerable to damage in the early stage of AD. We considered both inter-group (patients vs controls) and intra-group (right vs left hippocampus) comparisons. We examined seven patients meeting the DSM-III-R criteria of senile dementia and the National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association (NINCDS — ADRDA) criteria of probable AD, and II aged controls. This study focused on the measurement of phosphorus 31 (31P) Nuclear Magnetic Resonance (NMR) spectroscopy metabolites in each hippocampus. We found significant differences in phosphorus metabolites for both intra-group comparison (pH shifted towards relative alkalosis in the left hippocampus of patients) and inter-group consideration (reduced phosphodiesters [Pde]and elevated gamma adenosine triphosphate (ATP) in the right hippocampus, higher inorganic phosphate (pHi) in the left hippocampus for patients as compared to controls). We suggest energy failure and membrane functional breakdown in patients compared to aged controls.

Keywords

P31 NMR spectroscopyAlzheimer's diseaseageing
Type
Original article
Information
European Psychiatry , Volume 12 , Issue 3 , 1997 , pp. 140 - 148
Copyright
Copyright © Elsevier, Paris 1997

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