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Fluid-attenuated inversion-recovery MR imaging in schizophrenia-associated with idiopathic unconjugated hyperbilirubinemia (Gilbert's syndrome)

Published online by Cambridge University Press:  16 April 2020

Tsuyoshi Miyaoka ,
Rei Yasukawa ,
Takumi Mihara ,
Shoichi Mizuno ,
Hideaki Yasuda ,
Tsuruhei Sukegawa ,
Maiko Hayashida ,
Takuji Inagaki  and
Jun Horiguchi
Tsuyoshi Miyaoka*
Affiliation:
Department of Psychiatry, Shimane University School of Medicine, 89-1 Enyacho, Izumo693-8501, Japan
Rei Yasukawa
Affiliation:
Department of Psychiatry, Shimane University School of Medicine, 89-1 Enyacho, Izumo693-8501, Japan
Takumi Mihara
Affiliation:
Department of Psychiatry, Shimane University School of Medicine, 89-1 Enyacho, Izumo693-8501, Japan
Shoichi Mizuno
Affiliation:
Department of Psychiatry, Shimane University School of Medicine, 89-1 Enyacho, Izumo693-8501, Japan
Hideaki Yasuda
Affiliation:
Department of Psychiatry, Shimane University School of Medicine, 89-1 Enyacho, Izumo693-8501, Japan
Tsuruhei Sukegawa
Affiliation:
Department of Psychiatry, Shimane University School of Medicine, 89-1 Enyacho, Izumo693-8501, Japan
Maiko Hayashida
Affiliation:
Department of Psychiatry, Shimane University School of Medicine, 89-1 Enyacho, Izumo693-8501, Japan
Takuji Inagaki
Affiliation:
Department of Psychiatry, Shimane University School of Medicine, 89-1 Enyacho, Izumo693-8501, Japan
Jun Horiguchi
Affiliation:
Department of Psychiatry, Shimane University School of Medicine, 89-1 Enyacho, Izumo693-8501, Japan
*
*Corresponding author. Tel.: +81 853 20 2263; fax: +81 853 20 2260. E-mail address: [email protected] (T. Miyaoka).
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Abstract

Background

Patients with schizophrenia show a significantly higher frequency of hyperbilirubinemia the patients suffering from other psychiatric disorders and the general healthy population. The objective of the current study was to determine whether patients with schizophrenia-associated idiopathic unconjugated hyperbilirubinemia (Gilbert's syndrome, GS) have specific changes in signal intensities on fluid-attenuated inversion-recovery (FLAIR) magnetic resonance (MR) images.

Methods

Axial 5-mm-thick FLAIR MR images from schizophrenia patients with GS (n = 18) and schizophrenia patients without GS (n = 18), all diagnosed according to DSM-IV criteria, were compared with age- and sex-matched non-psychiatric controls (n = 18). Signal intensities in the hippocampus, amygdala, caudate, putamen, thalamus, cingulate gyrus, and insula were graded relative to cortical signal intensity in the frontal lobe.

Results

Compared to both schizophrenia patients without GS and normal controls, the schizophrenia patients with GS showed significantly increased signal intensities in almost all regions studied.

Conclusion

Patients with schizophrenia-associated GS have specific changes of signal intensities on FLAIR MR images, suggesting that schizophrenia with GS produces changes in the fronto-temporal cortex, limbic system, and basal ganglia.

Keywords

Fluid-attenuated inversion-recoveryMR imagingGilbert's syndromeSchizophrenia
Type
Original article
Information
European Psychiatry , Volume 20 , Issue 4 , June 2005 , pp. 327 - 331
Copyright
Copyright © Elsevier SAS 2005

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