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Feasibility of pharmacotherapy in HIV-related affective spectrum disorders: an open trial with fluvoxamine

Published online by Cambridge University Press:  16 April 2020

P Perretta ,
C Nisita ,
E Zaccagnini ,
C Lorenzetti ,
A Nuccorini ,
GB Cassano ,
DM McNair  and
HS Akiskal
P Perretta
Affiliation:
Psychiatric Clinic I, University of Pisa Via Roma 56, 56100Pisa, Italy
C Nisita
Affiliation:
Psychiatric Clinic I, University of Pisa Via Roma 56, 56100Pisa, Italy
E Zaccagnini
Affiliation:
Psychiatric Clinic I, University of Pisa Via Roma 56, 56100Pisa, Italy
C Lorenzetti
Affiliation:
Psychiatric Clinic I, University of Pisa Via Roma 56, 56100Pisa, Italy
A Nuccorini
Affiliation:
Psychiatric Clinic I, University of Pisa Via Roma 56, 56100Pisa, Italy
GB Cassano*
Affiliation:
Psychiatric Clinic I, University of Pisa Via Roma 56, 56100Pisa, Italy
DM McNair
Affiliation:
Boston University, Boston, MA
HS Akiskal
Affiliation:
University of California at San Diego, San Diego, CA, USA
*
*Correspondence and reprints.
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Summary

Among HIV patients treated for AIDS-related adjustment, major depressive disorders and other affective disorders, we assessed in an open study the feasibility of using a serotonergic antidepressant (fluvoxamine). Thirty-five seropositive patients with the above conditions (22 men and 13 women) were followed over a minimum period of four weeks. At the end of the treatment, a large number of patients (77%) showed marked improvement. “Nuclear” depressive and anxiety symptoms remitted, while the “somatic” ones seemed less sensitive to treatment. Treatment had to be terminated prematurely due to side effects in only two patients (6%).

Keywords

fluvoxaminetreatmentHIV patientsaffective spectrum disordersorganic mood disorder
Type
Original article
Information
European Psychiatry , Volume 11 , Issue 1 , 1996 , pp. 40 - 45
Copyright
Copyright © 1996 Elsevier, Paris

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