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Emotion processing in joint hypermobility: A potential link to the neural bases of anxiety and related somatic symptoms in collagen anomalies

Published online by Cambridge University Press:  15 April 2020

N. Mallorquí-Bagué ,
A. Bulbena ,
N. Roé-Vellvé ,
E. Hoekzema ,
S. Carmona ,
E. Barba-Müller ,
J. Fauquet ,
G. Pailhez  and
O. Vilarroya
N. Mallorquí-Bagué*
Affiliation:
Department of Psychiatry and Forensic Medicine, School of Medicine, Campus de la Universitat Autonoma de Barcelona (UAB), Barcelona, Spain Psychiatry, Psychology and Psychosomatics department, Institut Universitari Quirón Dexeus, Barcelona, Spain Neuroimaging Research Group, Fundació IMIM, Doctor Aiguader, 88, 08003Barcelona, Spain
A. Bulbena
Affiliation:
Department of Psychiatry and Forensic Medicine, School of Medicine, Campus de la Universitat Autonoma de Barcelona (UAB), Barcelona, Spain Fundació IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain Anxiety Unit, Institute of Neuropsychiatry and Addictions (INAD), Hospital del Mar, Universitat Autònoma de Barcelona, Barcelona, Spain
N. Roé-Vellvé
Affiliation:
Neuroimaging Research Group, Fundació IMIM, Doctor Aiguader, 88, 08003Barcelona, Spain
E. Hoekzema
Affiliation:
Neuroimaging Research Group, Fundació IMIM, Doctor Aiguader, 88, 08003Barcelona, Spain Netherlands Institute for Neuroscience, Meibergdreef 47, 1105 BAAmsterdam, The Netherlands
S. Carmona
Affiliation:
Neuroimaging Research Group, Fundació IMIM, Doctor Aiguader, 88, 08003Barcelona, Spain Centro de Investigación Biomédica en Red de Salud mental, Madrid, Spain Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain Departamento de Bioingeniería e Ingeniería Aeroespacial, Universidad Carlos III de Madrid, Madrid, Spain
E. Barba-Müller
Affiliation:
Department of Psychiatry and Forensic Medicine, School of Medicine, Campus de la Universitat Autonoma de Barcelona (UAB), Barcelona, Spain Neuroimaging Research Group, Fundació IMIM, Doctor Aiguader, 88, 08003Barcelona, Spain
J. Fauquet
Affiliation:
Neuroimaging Research Group, Fundació IMIM, Doctor Aiguader, 88, 08003Barcelona, Spain Department Psicobiologia i Metodologia de les Ciències de la Salut, Campus de la UAB, 08193 Bellaterra (Cerdanyola del Vallés), Barcelona, Spain
G. Pailhez
Affiliation:
Department of Psychiatry and Forensic Medicine, School of Medicine, Campus de la Universitat Autonoma de Barcelona (UAB), Barcelona, Spain Fundació IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain Anxiety Unit, Institute of Neuropsychiatry and Addictions (INAD), Hospital del Mar, Universitat Autònoma de Barcelona, Barcelona, Spain
O. Vilarroya
Affiliation:
Department of Psychiatry and Forensic Medicine, School of Medicine, Campus de la Universitat Autonoma de Barcelona (UAB), Barcelona, Spain Neuroimaging Research Group, Fundació IMIM, Doctor Aiguader, 88, 08003Barcelona, Spain
*
*Corresponding author. Passeig Marítim 25, 08003 Barcelona, Spain. Tel.: +34 932483495; fax: +34 932483445. E-mail address:[email protected] (N. Mallorquí-Bagué).
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Abstract

Background:

Joint hypermobility syndrome (JHS) has repeatedly been associated with anxiety and anxiety disorders, fibromyalgia, irritable bowel syndrome and temporomandibular joint disorder. However, the neural underpinnings of these associations still remain unclear. This study explored brain responses to facial visual stimuli with emotional cues using fMRI techniques in general population with different ranges of hypermobility.

Methods:

Fifty-one non-clinical volunteers (33 women) completed state and trait anxiety questionnaire measures, were assessed with a clinical examination for hypermobility (Beighton system) and performed an emotional face processing paradigm during functional neuroimaging.

Results:

Trait anxiety scores did significantly correlate with both state anxiety and hypermobility scores. BOLD signals of the hippocampus did positively correlate with hypermobility scores for the crying faces versus neutral faces contrast in ROI analyses. No results were found for any of the other studied ROIs. Additionally, hypermobility scores were also associated with other key affective processing areas (i.e. the middle and anterior cingulate gyrus, fusiform gyrus, parahippocampal region, orbitofrontal cortex and cerebellum) in the whole brain analysis.

Conclusions:

Hypermobility scores are associated with trait anxiety and higher brain responses to emotional faces in emotion processing brain areas (including hippocampus) described to be linked to anxiety and somatic symptoms. These findings increase our understanding of emotion processing in people bearing this heritable variant of collagen and the mechanisms through which vulnerability to anxiety and somatic symptoms arises in this population.

Keywords

Functional magnetic resonance imaging (fMRI)EmotionJoint hypermobilityAnxietyPsychosomatics
Type
Original article
Information
European Psychiatry , Volume 30 , Issue 4 , June 2015 , pp. 454 - 458
Copyright
Copyright © Elsevier Masson SAS 2015

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