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The effects of trazodone on sleep disturbances induced by brofaromine

Published online by Cambridge University Press:  16 April 2020

PMJ Haffmans  and
MS Vos
PMJ Haffmans
Affiliation:
Stichting RBC, location Monsterseweg, Monsterseweg 83, 2553the Hague, the Netherlands
MS Vos
Affiliation:
Stichting RBC, location Monsterseweg, Monsterseweg 83, 2553the Hague, the Netherlands
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Summary

The effects of trazodone on subjective and objective sleep parameters were compared to those of placebo in a double-blind design in seven patients who developed insomnia during treatment with the selective and reversible MAO-A inhibitor, brofaromine. Trazodone significantly increased deep sleep and altered the architecture of sleep in these patients. Subjectively, patients reported a better and deeper sleep. No negative interactions between brofaromine and trazodone were observed and side-effects were minimal. A low dose of trazodone may be a safe and effective agent in the treatment of MAO-I induced insomnia.

Keywords

depressioninsomniaMAO-A inhibitortrazodone
Type
Short Communications
Information
European Psychiatry , Volume 14 , Issue 3 , June 1999 , pp. 167 - 171
Copyright
Copyright © European Psychiatric Association 1999

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