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Effects of tianeptine on behavioural and neurochemical responses to immobilization stress

Published online by Cambridge University Press:  16 April 2020

G Curzon  and
KP Datla
G Curzon
Affiliation:
Department of Neurochemistry, Institute of Neurology, 1 Wakefield Street, London, WCIN IPJ, UK
KP Datla
Affiliation:
Department of Neurochemistry, Institute of Neurology, 1 Wakefield Street, London, WCIN IPJ, UK
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Summary

The novel antidepressant drug tianeptine had an antidepressant-like effect on a rat model of depression based on the deficit in open field activity observed on the day after 2 h immobilization. Thus, tianeptine (10 mg/kg ip) given 2 h after the end of the immobilization period led to the deficit being opposed. Similar results were obtained using rats previously given 10 mg/kg of the drug per day for 13 days and a final dose 2 h after the end of immobilization. Other workers have found that tianeptine attenuates stress-induced activation of the hypothalamo-pituitary-adrenal axis. Possible relationships between these findings are discussed together with the paradoxical co-existence of the antidepressant properties of tianeptine with its ability to decrease the availability of 5-HT to receptors.

Keywords

antidepressant drugscorticosteronedepression5-HTtianeptine
Type
Research Article
Information
European Psychiatry , Volume 8 , Issue S2: Neuroendocrinological aspects of depression 28 June 1992, Nice, France , 1993 , pp. 61s - 66s
Copyright
Copyright © Elsevier, Paris 1993

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