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The dopamine D2 receptor gene TaqI A polymorphism is not associated with Novelty Seeking, Harm Avoidance and Reward Dependence in healthy subjects

Published online by Cambridge University Press:  16 April 2020

B de Brettes ,
I Berlin ,
C Laurent ,
JP Lépine ,
J Mallet  and
AJ Puech
B de Brettes
Affiliation:
Service de Pharmacologie, Hôpital Pitié-Salpêtrière, 47, Boulevard de l'Hôpital, 75013Paris
I Berlin*
Affiliation:
Service de Pharmacologie, Hôpital Pitié-Salpêtrière, 47, Boulevard de l'Hôpital, 75013Paris
C Laurent
Affiliation:
Laboratoire de Génétique moléculaire de la Neurotransmission et des Processus Neurodégénératifs C 9923 CNRS, Hôpital Pitié-Salpêtrière
JP Lépine
Affiliation:
Service de Psychiatrie, Hôpital Fernand Widal, Paris, France
J Mallet
Affiliation:
Laboratoire de Génétique moléculaire de la Neurotransmission et des Processus Neurodégénératifs C 9923 CNRS, Hôpital Pitié-Salpêtrière
AJ Puech
Affiliation:
Service de Pharmacologie, Hôpital Pitié-Salpêtrière, 47, Boulevard de l'Hôpital, 75013Paris
*
*Correspondence and reprints.
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Summary

Allele A1 of the TaqI A restriction fragment length polymorphism (RFLP) of the dopamine D2 receptor gene has been found to be associated with substance abuse and alcoholism. The personality trait of Novelty Seeking (NS) is also associated with substance abuse and dependence. We hypothesised, on the basis of involvement of dopaminergic mechanisms in substance abuse, that the presence of allele A1 of the dopamine D2 receptor gene may represent a genetic predisposition for the NS personality trait. We investigated, therefore, whether the allele A1 of the TaqI A RFLP of the dopamine D2 receptor gene is associated with the NS dimension of the Tridimensional Personality Questionnaire (TPQ) in healthy Caucasian subjects with no history of alcohol or substance abuse or dependence. We genotyped 204 subjects aged 18 to 30 years. There was no association between any of the alleles of the D2 receptor genes and any of the TPQ scores (NS, Harm Avoidance, Reward Dependence). We conclude that allele A1 of the TaqI A RFLP of the dopamine D2 receptor is not associated with NS personality trait in healthy Caucasian subjects.

Keywords

personality traitsgenotypedopamine D2 receptor
Type
Short communication
Information
European Psychiatry , Volume 13 , Issue 8 , December 1998 , pp. 427 - 430
Copyright
Copyright © Elsevier, Paris 1998

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