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Dexamethasone suppression test and prediction of treatment response to selective antidepressants

Published online by Cambridge University Press:  16 April 2020

M Ansseau ,
P Papart ,
W Pitchot ,
M Timsit-Berthier ,
JJ Legros  and
R von Frenckell
M Ansseau
Affiliation:
Psychiatric Unit
P Papart
Affiliation:
Psychiatric Unit
W Pitchot
Affiliation:
Psychiatric Unit
M Timsit-Berthier
Affiliation:
Laboratory of Applied Cognitive Psychophysiology
JJ Legros
Affiliation:
Psychoneuroendocrinology Unit, Centre Hospitalier Universitaire du Sart Tilman, B-4000Liège, Belgium
R von Frenckell
Affiliation:
Psychiatric Unit
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Summary

The usefulness of the dexamethasone suppression test (DST) in the prediction of treatment response to selective antidepressants was tested in 56 major depressive inpatients. Following DST, patients were randomly assigned to treatment by either nomifensine, a catecholaminergic antidepressant, or zimeldine, a serotonergic antidepressant during a 3-week period and assessed by means of the second part of the Clinical Global Impressions (CGI-2). No significant difference was present between the 27 DST suppressor and the 29 DST non-suppressor patients in their overall clinical outcome. Moreover, no preferential response to nomifensine or zimeldine was noted in any of the two groups defined according to DST status. Therefore, these results do not support the usefulness of the DST in the prediction of the treatment response to antidepressants in general and to selective antidepressants in particular.

Keywords

dexamethasone suppression testprediction of outcomeantidepressantsnomifensinezimeldine
Type
Short communication
Information
European Psychiatry , Volume 7 , Issue 4 , 1992 , pp. 191 - 194
Copyright
Copyright © Elsevier, Paris 1992

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References

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