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Cost of depression: effect of adherence and treatment response

Published online by Cambridge University Press:  16 April 2020

L. von Knorring ,
A.-C. Åkerblad ,
F. Bengtsson ,
Å. Carlsson  and
L. Ekselius
L. von Knorring*
Affiliation:
Department of Neuroscience, Psychiatry, Uppsala University Hospital, Uppsala University, 75185Uppsala, Sweden
A.-C. Åkerblad
Affiliation:
Department of Neuroscience, Psychiatry, Uppsala University Hospital, Uppsala University, 75185Uppsala, Sweden Medical Department, Pfizer AB, Täby, Sweden
F. Bengtsson
Affiliation:
Division of Clinical Pharmacology, Medicine and Care, Faculty of Health Sciences, Linköping University, Linköping, Sweden
Å. Carlsson
Affiliation:
Medical Department, Pfizer AB, Täby, Sweden
L. Ekselius
Affiliation:
Department of Neuroscience, Psychiatry, Uppsala University Hospital, Uppsala University, 75185Uppsala, Sweden
*
*Corresponding author. E-mail address: [email protected] (L. von Knorring).
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Abstract

Objectives:

The purpose of the present study has been to assess the societal cost of major depression and the distribution into different cost components. The impact of adherence and treatment response was also explored.

Method:

Data were collected from a randomized controlled trial of patients with major depressive disorder who were treated in a naturalistic primary care setting. Resource use and quality of life were followed during the two-year trial.

Results:

The mean total cost per patient during two years was KSEK 363 (EUR 38 953). Indirect costs were the most important component (87%), whereas the cost of drugs was minor (4.5%). No significant differences in costs or quality of life between treatment arms or between adherent and non-adherent patients were demonstrated. However, treatment responders had 39% lower total costs per patient and experienced a larger increase in quality of life compared to non-responders.

Conclusions:

Major depression has high costs for society, primarily due to indirect costs. Treatment responders have considerably lower costs per patient and higher quality of life than non-responders. This indicates that measures to increase response rates are also important from an economic perspective.

Keywords

DepressionCost of illnessQuality of lifeComplianceAdherenceResponse
Type
Original article
Information
European Psychiatry , Volume 21 , Issue 6 , September 2006 , pp. 349 - 354
Copyright
Copyright © Elsevier SAS 2006

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