Hostname: page-component-cd9895bd7-jn8rn Total loading time: 0 Render date: 2024-12-25T14:00:54.499Z Has data issue: false hasContentIssue false
  • English
  • Français

COMT Val158Met polymorphism is related with interpersonal problem solving in schizophrenia

Published online by Cambridge University Press:  16 April 2020

A. Üçok ,
M. Öztürk ,
Z. Duman  and
G. Saruhan-Direskeneli
A. Üçok*
Affiliation:
Istanbul University, Istanbul Faculty of Medicine, Department of Psychiatry, Millet Street, Capa, 34390Istanbul, Turkey
M. Öztürk
Affiliation:
Istanbul University, Istanbul Faculty of Medicine, Department of Psychiatry, Millet Street, Capa, 34390Istanbul, Turkey
Z. Duman
Affiliation:
Dokuz Eylul University, School of Nursing, Izmir, Turkey
G. Saruhan-Direskeneli
Affiliation:
Istanbul University, Istanbul Faculty of Medicine, Department of Physiology, Istanbul, Turkey
*
*E-mail address: [email protected] (A. Üçok).
Get access

Abstract

Objective

The aim of this study was to investigate associations between COMT Val158Met polymorphism, and interpersonal problem solving capacity and cognitive functions in schizophrenia.

Methods

COMT Val158Met polymorphism was studied with ARMS-PCR method in 99 outpatients with schizophrenia. Brief Psychiatric Rating Scale was used to assess symptom severity. The Assessment of Interpersonal Problem Solving Skills (AIPSS) was used to evaluate problem solving capacity. Continuous Performance Test (CPT) and Wisconsin Card Sorting Test (WCST), were used to measure cognition.

Results

Patients with Met/Met genotype had higher AIPSS subscores for detecting the problem, than those with Val/Val at baseline (p = 0.02). Met allele was also found to be related with higher AIPSS-receiving skills (p = 0.04). Val allele was found to be related with more commission errors in CPT (p = 0.03). There was no relation between Val158Met polymorphism and WCST and clinical measurements.

Conclusion

Our findings suggest that Val allele might be related to poor performance on detecting the interpersonal problems, and attention in schizophrenia.

Keywords

SchizophreniaCOMT Val158MetCognitionAttentionInterpersonal problem solving
Type
Psychiatric Genetics
Information
European Psychiatry , Volume 25 , Issue 6 , October 2010 , pp. 320 - 322
Copyright
Copyright © Elsevier Masson SAS 2010

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Addington, J, Addington, DNeurocognitive and social functioning in schizophrenia. Schizophr Bull 1999;25:173–182.CrossRefGoogle Scholar
Bertolino, A, Rubino, V, Sambataro, F, Blasi, G, Latorre, V, Fazio, Let al.Prefrontal-hippocampal coupling during memory processing is modulated by COMT val158met genotype. Biol Psychiatry 2006;60:1250–1258.CrossRefGoogle ScholarPubMed
Bilder, RM, Volavka, J, Czobor, P, Malhotra, AK, Kennedy, JL, Ni, Xet al.Neurocognitive correlates of the COMT Val(158)Met polymorphism in chronic schizophrenia. Biol Psychiatry 2002;52:701–707.CrossRefGoogle ScholarPubMed
Blasi, G, Mattay, VS, Bertolino, A, Elvevåg, B, Callicott, JH, Das, Set al.Effect of catechol-O-methyltransferase val158met genotype on attentional control. J Neurosci 2005;25:5038–5045.CrossRefGoogle ScholarPubMed
Donahoe, CP, Carter, MJ, Bloem, WD, Hirsch, GL, Laasi, N, Wallace, CJAssessment of interpersonal problem solving skills. Psychiatry 1990;53:329–339.CrossRefGoogle ScholarPubMed
Egan, MF, Goldberg, TE, Kolachana, BS, Callicott, JH, Mazzanti, CM, Straub, REet al.Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. PNAS 2001;98:6917–6922.CrossRefGoogle ScholarPubMed
Heaton, RKWisconsin Cart Sorting Test Manual. Odessa: Psychological Assessment resources; 1980.Google Scholar
Li, T, Ma, X, Hu, X, Wang, Y, Yan, C, Meng, Het al.PRODH gene is associated with executive function in schizophrenic families. Am J Med Genet B Neuropsychiatr Genet 147B 2008 654–657.CrossRefGoogle ScholarPubMed
Lukoff, D, Liberman, RP, Nuechterlein, KHSymptom monitoring in the rehabilitation of schizophrenic patients. Schizophr Bull 1986;12:578–602.CrossRefGoogle ScholarPubMed
Roffman, JL, Weiss, AP, Deckersbach, T, Freudenreich, O, Henderson, DC, Wong, DHet al.Interactive effects of COMT Val108/158Met and MTHFR C677T on executive function in schizophrenia. Am J Med Genet B Neuropsychiatr Genet 2008;147:990–995.CrossRefGoogle Scholar
Ruiz-Sanz, JI, Aurrekoetxea, I, Ruiz del Agua, A, Ruiz-Larrea, MBDetection of catechol-O-methyltransferase Val158Met polymorphism by a simple one-step tetra-primer amplification refractory mutation system-PCR. Mol Cell Prob 2007;21:202–207.CrossRefGoogle ScholarPubMed
Ucok, A, Atlı, H, Cetinkaya, Z, Kandemir, PETurkish version of the assessment of interpersonal problem solving skills. Arch Neuropsi 2002;39:113–118. [in Turkish]Google Scholar
Ucok, A, Alpsan, H, Cakir, S, Saruhan-Direskeneli, GAssociation of a serotonin receptor 2A gene polymorphism with cognitive functions in patients with schizophrenia. Am J Med Genet B Neuropsychiatr Genet 2007;144:704–707.CrossRefGoogle Scholar
Ucok, A, Çakır, S, Çetinkaya, Z, Dişcigil, A, Kandemir, P, Atlı, HCognitive predictors of skill acquisition on social problem solving in patients with schizophrenia. Eur Arch Psychiatr Clin Neurosci 2006;256:388–394.CrossRefGoogle ScholarPubMed
Submit a response

Comments

No Comments have been published for this article.