Hostname: page-component-78c5997874-fbnjt Total loading time: 0 Render date: 2024-11-04T20:26:36.206Z Has data issue: false hasContentIssue false
  • English
  • Français

Are there differential effects of fluoxetine in retarded/blunted affect versus agitated/anxious depressives? A clinical study

Published online by Cambridge University Press:  16 April 2020

A Partiot ,
R Jouvent ,
A Pierson ,
P Baruch ,
JN Beuzen ,
S Ammar  and
D Widlöcher
A Partiot
Affiliation:
Laboratoire Lilly France, 203, Bureaux de la Colline, 92213Saint-Cloud
R Jouvent*
Affiliation:
CNRS URA 1957
A Pierson
Affiliation:
Laboratoire Lilly France, 203, Bureaux de la Colline, 92213Saint-Cloud
P Baruch
Affiliation:
Département de Psychiatrie, Hôpital de l'Enfant-Jésus, 1401, 18e rue, Québec, G1J 1Z4, Canada
JN Beuzen
Affiliation:
Laboratoire Lilly France, 203, Bureaux de la Colline, 92213Saint-Cloud
S Ammar
Affiliation:
CNRS URA 1957
D Widlöcher
Affiliation:
Service de Psychiatrie Adulte, Hôpital de La Salpêtrière, Pavillon Clérambault, 47, boulevard de l'Hôpital, 75013Paris, France
*
*Correspondence and reprints: R Jouvent, CNRS URA 1957, Personnalité et Conduites Adaptives, Pavilion Clérambault, Hôpital de La Salpêtrière, 47, boulevard de l'Hôspital,75013 Paris, France.
Get access

Summary

Background

Clinical selectivity of antidepressants with pharmacological specificity still remains under debate.

Method

In the open trial presented below, the effects of fluoxetine, a selective serotonin re-uptake inhibitor (SSRI), were compared across two groups of depressive inpatients contrasted on their symptomatological expression (agitated/anxious versus retarded/blunted affect). Sixteen patients (8 in each groups) were included in the 4-weeks treatment period and submitted to a weekly-based evaluation. Global depression, retardation, emotional blunting, agitation, anxiety and mood profile were assessed.

Results

Significant improvements of the HDRS and MADRS scores were observed in both groups. Although no group x treatment interaction was found on the global scores of depression, a differential effect according to the group was observed on anxiety, agitation, irritability and emotional lability.

Discussion

These preliminary results support the hypothesis that the effect of fluoxetine on positive clinical dimensions could lead to a differential effect in patients with agitation/anxiety when compared with patients with retardation/blunted affect.

Keywords

depressionSSRIclinical dimensionsanxietyblunted-affectagitationretardationantidepressants
Type
Original article
Information
European Psychiatry , Volume 12 , Issue 1 , 1997 , pp. 21 - 27
Copyright
Copyright © Elsevier, Paris 1997

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Abrams, R, Taylor, MA. A rating scale for emotional blunting. Am J Psychiatry 1978; 135: 226–229Google ScholarPubMed
Carney, MWP, Roth, M, Garside, RF. The diagnosis of depressive syndromes and prediction of ECT response. Br J Psychiatry 1965; 111: 659–674CrossRefGoogle Scholar
Dalery, J, Bouhassira, M, Kress, JP, Lancrenon, S, Tafani, A, Hantouche, EG. Dépressions majeures agitées-anxieuses versus émoussées-ralenties: effets différentiels de la fluoxétine. Encéphale 1995; 21: 217–225Google Scholar
Davidson, J, Turnbull, C, Strickland, R, Belyea, M. Comparative diagnostic criteria for melancholia and endogeneous depression. Arch Gen Psychiatry 1984; 41: 506–511CrossRefGoogle Scholar
Hamilton, M. A rating scale for depression. J Neurol Neurosurg Psychiatry 1960; 23: 56–62CrossRefGoogle ScholarPubMed
Jouvent, R. Evaluating the affective and cognitive effect of a drug: theoretical and methodological considerations. Arch Gerontol Geriatry 1989; 1: 165–172Google Scholar
Jouvent, R, Vindreau, C, Montreuil, M, Bungener, C, Widlöcher, D. La clinique polydimensionnelle de l'humeur dépressive. Nouvelle version de l'échelle EHD. Psychiatrie Psychobiologie 1988; 3: 245–253CrossRefGoogle Scholar
Montgomery, SA, Aìšsberg, MA. A new depression scale designed to be sensitive to change. Br J Psychiatry 1979; 134: 382–389CrossRefGoogle ScholarPubMed
Partiot, A, Pierson, A, Dodin, V, Ammar, S, Jouvent, R, Renault, B. Information process in depressives. Biol Psychiatry 1992; 31(11): 1175–1177CrossRefGoogle ScholarPubMed
Tyrer, P, Owen, RT, Cicchetti, DV. The brief scale for anxiety: A subdivision of the comprehensive psychopathological rating scale. J Neurol Neurosurg Psychiatry 1984; 47: 970–975CrossRefGoogle ScholarPubMed
Van Praag, HM, Brown, SL, Asnis, GM, et al.Beyond serotonin. A multi-aminergic perspective on abnormal behaviorBrown, SLPraag, HM VanThe Role of Serotonin in Psychiatric Disorders New-York: Bruner-Mazel Publishers, 1990; 302–332Google Scholar
Widlöcher, DPsychomotor retardation: clinical, theoretical and psychometric aspectsAkiskal, HThe Psychiatric Clinics of North America vol 6 Philadelphia: Saunders WB, 1983; 27–40Google Scholar
Submit a response

Comments

No Comments have been published for this article.