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Antinuclear autoantibodies in relation to bipolar affective disorder and lithium therapy

Published online by Cambridge University Press:  16 April 2020

B Spivak ,
M Radwan ,
P Bartur ,
R Mester  and
A Weizman
B Spivak
Affiliation:
Research Unit, Ness Ziona Psychiatric Hospital, Ness Ziona
M Radwan
Affiliation:
Geha Psychiatric Hospital, Beilinson Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv
P Bartur
Affiliation:
Laboratory of Clinical Immunology, Zamenhoff Laboratory Center, Tel Aviv
R Mester
Affiliation:
Research Unit, Ness Ziona Psychiatric Hospital, Ness Ziona
A Weizman
Affiliation:
Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Beilinson Medical Center, and Research Unit, Geha Psychiatric Hospital, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
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Summary

We investigated the presence of antinuclear antibodies (ANA) in 63 drug free and lithium treated bipolar patients as compared to 37 healthy controls. Increased frequency of positive ANA was detected in bipolar patients in comparison to controls (19% vs 5%, respectively, P < 0.05). This finding was unrelated to lithium treatment. No antinative DNA antibodies or antihistone reactive antibodies were detected among the ANA positive subjects.

Keywords

bipolar affective disorderlithiumantinuclear antibodies (ANA)autoimmunity
Type
Short communication
Information
European Psychiatry , Volume 11 , Issue 1 , 1996 , pp. 50 - 52
Copyright
Copyright © 1996 Elsevier, Paris

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