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An fMRI study of emotional face encoding in youth at risk for bipolar disorder

Published online by Cambridge University Press:  15 April 2020

W.-L. Tseng ,
B.L. Bones ,
R.R. Kayser ,
A.K. Olsavsky ,
S.J. Fromm ,
D.S. Pine ,
E. Leibenluft  and
M.A. Brotman
W.-L. Tseng*
Affiliation:
Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
B.L. Bones
Affiliation:
Georgetown University School of Medicine, Washington, DC, USA.
R.R. Kayser
Affiliation:
Georgetown University School of Medicine, Washington, DC, USA.
A.K. Olsavsky
Affiliation:
UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA.
S.J. Fromm
Affiliation:
Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
D.S. Pine
Affiliation:
Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
E. Leibenluft
Affiliation:
Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
M.A. Brotman
Affiliation:
Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
*
* Corresponding author at: Building 15K Room 208, MSC 2670, 15K North Drive, Bethesda, MD 20892, USA. E-mail address:[email protected] (W.-L. Tseng).
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Abstract

Face memory deficits may be a bipolar disorder (BD) endophenotype. BD (n = 27) and unaffected youth at risk (n = 13) exhibited middle frontal gyrus hypoactivation during successful vs. unsuccessful encoding. Parahippocampal gyrus dysfunction was found in BD and at-risk youth (vs. low-risk, n = 37). Middle occipital gyrus hypoactivation was only present in BD.

Keywords

fMRIPediatric bipolar disorderAt riskFace memoryEndophenotype
Type
Short communication
Information
European Psychiatry , Volume 30 , Issue 1 , January 2015 , pp. 94 - 98
Copyright
Copyright © European Psychiatric Association 2020

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