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Amisulpride versus fluoxetine in dysthymia: preliminary results of a double-blind comparative study

Published online by Cambridge University Press:  16 April 2020

E Smeraldi ,
E Haefele ,
G Crespi ,
GL Casadei ,
F Biondi  and
E Vigorelli
E Smeraldi
Affiliation:
Ospedale San Raffaele, via Prinetti 29, 20127Milan
E Haefele
Affiliation:
Ospedale San Raffaele, via Prinetti 29, 20127Milan
G Crespi
Affiliation:
Ospedale San Raffaele, via Prinetti 29, 20127Milan
GL Casadei
Affiliation:
Medical Department, Synthélabo, Limito, Italy
F Biondi
Affiliation:
Medical Department, Synthélabo, Limito, Italy
E Vigorelli
Affiliation:
Medical Department, Synthélabo, Limito, Italy
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Summary

The efficacy and safety of low doses of amisulpride (50 mg/day) and of fluoxetine (20 mg/day) were compared respectively in 139 and 129 outpatients with dysthymia during three months in a multi-centre double-blind trial. No statistically significant difference between the two groups was found in the number of responders at study-end with the Montgomery and Asberg Depressive Rating Scale, which was the main criterion for efficacy. In addition, amisulpride was well tolerated. These preliminary results suggest that low doses of amisulpride may be effective in the treatment of dysthymic patients.

Keywords

amisulpridebenzamidetreatmentdysthymiafluoxetine
Type
Research Article
Information
European Psychiatry , Volume 11 , Issue S3 , 1996 , pp. 141s - 143s
Copyright
Copyright © Elsevier paris 1996

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