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Amisulpride in dysthymia: results of a naturalistic study in general practice

Published online by Cambridge University Press:  16 April 2020

M Paes de Sousa*
Affiliation:
Department of Psychiatry, Hospital de Santa Maria, Av Egas Moniz 1600 Lisbon, Portuga
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Summary

A naturalistic study was conducted in general practice in Portugal on the efficacy and tolerance of low doses of amisulpride in the treatment of dysthymia. A total of 109 patients received low doses (50 – 100 mg) of amisulpride for four weeks. A global evaluation showed good or very good efficacy and tolerance in more than 80% of the patients. The social disability observed at baseline was significantly improved after the four-week treatment period. Few adverse events were observed and only four patients dropped out due to side effects. Our results suggest that low doses of amisulpride might be a safe and effective treatment for dysthymia in clinical practice.

Type
Research Article
Copyright
Copyright © Elsevier paris 1996

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References

Boyer, PLecrubier, YPuech, A et al. Treatment of dysthymia with low doses of amisulpride vs aminepline. Clin Neuropharmacol 1992; 15(1B):23CrossRefGoogle Scholar
Deniker, PGinestet, DNeuroleptiques. In: Encycl Méd-Chir Psychiatrie. 37860 B20. Paris: Elsevier, 1973Google Scholar
Gekière, FRoger, BSoret, CBorenstein, PBiological tolerance of amisulpride with long-term treatment. In:Borenstein, et al. Amisulpride. Paris: Expansion Scientifique Française, 1989; 181–7Google Scholar
Gessa, GDysthymia and depressive disorders: dopamine hypothesis. Eur Psychiatry 1996:this issueGoogle Scholar
Jenner, PMarsden, CDSubstituted benzamide drugs as selective neuroleptic agents. Neuropharmacology 1981; 20:1285–93Google ScholarPubMed
Lecrubier, YPuech, ASimon, PWidlocher, DSchizophrénie: hyper ou hypofonctionnement du système dopaminergique? Une hypothèse bipolaire. Psychologie Méd 1980; 12:2431–41Google Scholar
Lecrubier, YPuech, AJAubin, FBoyer, PDeyrieux, BImprovement by amisulpride of the negative syndrome in non-psychotic subjects. A preliminary study. Psychiatry Psychobwl 1988; 3(5):329–33CrossRefGoogle Scholar
Lecrubier, YPuech, AJBoyer, PThe Contribution of Neuropharmacology to the Understanding of Ill-Defined Psychological Disorders. In: Sartorius, NGoldberg, Dde Girolamo, GCosta e Silva, JALecrubier, YWittchen, Psychological Disorders in General Medical Settings. New York: Hogrefe & Huber Publishers, 1990; 98110Google Scholar
Protais, PHermier, CCostentin, JThe discriminant dopamine antagonist property of benzamides is observed at various times after their systemic or intracerebroventricular administration. Neuropharmacology 1985; 24:861867CrossRefGoogle ScholarPubMed
Puech, ASimon, PBoissier, JRBenzamides and classical neuroleptics. Comparison of their action using 6-apomorphine- induced effects. Eur J Pharmacol 1978; 50:291300CrossRefGoogle Scholar
Sedvall, CAlfredsson, GBjerkenstedt, LHarnryd, COxenstierna, GWiesel, FAClinical, biochemical and pharmacokinetic studies of sulpiride in schizophrenic patients. In: Ackenheil, MMatussek, MSpecial aspects of psychopharmacology. Paris: Expansion Scientifique Française, 1983; 153–70Google Scholar
Sheehan, DVThe anxiety disease. New York: Scribner and Sons, 1983Google Scholar
Sokoloff, PMartres, MPSchwartz, JCThree classes of dopamine receptor (D2, D3, D4) identified by binding studies with 3H-apomorphine and 3H-domperidone. Naunyn-Schmiedeberg's Arch Pharmacol 1980; 315:89102CrossRefGoogle Scholar
WPA Dysthymia Working Group Dysthymia in clinical practice. Br J Psychiatry 1995; 166:174–83CrossRefGoogle Scholar
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