Hostname: page-component-745bb68f8f-f46jp Total loading time: 0 Render date: 2025-01-07T21:23:38.822Z Has data issue: false hasContentIssue false
  • English
  • Français

Abnormalities in Cortical Gray Matter Density in Borderline Personality Disorder

Published online by Cambridge University Press:  15 April 2020

R. Rossi ,
M. Lanfredi ,
M. Pievani ,
M. Boccardi ,
P.E. Rasser ,
P.M. Thompson ,
E. Cavedo ,
M. Cotelli ,
S. Rosini  and
R. Beneduce
...Show all authors
R. Rossi*
Affiliation:
Unit of Psychiatry, IRCCS Istituto Centro San Giovanni di Dio-Fatebenefratelli, via Pilastroni 4, 25125Brescia, Italy
M. Lanfredi
Affiliation:
Unit of Psychiatry, IRCCS Istituto Centro San Giovanni di Dio-Fatebenefratelli, via Pilastroni 4, 25125Brescia, Italy
M. Pievani
Affiliation:
LENITEM, Laboratory of Epidemiology, Neuroimaging, & Telemedicine, Istituto Centro San Giovanni di Dio-Fatebenefratelli, Brescia, Italy
M. Boccardi
Affiliation:
LENITEM, Laboratory of Epidemiology, Neuroimaging, & Telemedicine, Istituto Centro San Giovanni di Dio-Fatebenefratelli, Brescia, Italy
P.E. Rasser
Affiliation:
Centre for translational Neuroscience and Mental Health, The University of Newcastle, New South Wales, Australia Schizophrenia Research Institute, Darlinghurst, Australia Hunter Medical Research Institute, Newcastle, Australia
P.M. Thompson
Affiliation:
Imaging Genetics Center, Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA, USA
E. Cavedo
Affiliation:
LENITEM, Laboratory of Epidemiology, Neuroimaging, & Telemedicine, Istituto Centro San Giovanni di Dio-Fatebenefratelli, Brescia, Italy Cognition, neuroimaging and brain diseases Laboratory, Centre de Recherche de l’Insitut du Cerveau et de la Moelle (CRICM) UMRS_975, Université Pierre-et-Marie-Curie, Paris, France
M. Cotelli
Affiliation:
Unit of Neuropsychology, IRCCS Istituto Centro San Giovanni di Dio-Fatebenefratelli, Brescia, Italy
S. Rosini
Affiliation:
Unit of Neuropsychology, IRCCS Istituto Centro San Giovanni di Dio-Fatebenefratelli, Brescia, Italy
R. Beneduce
Affiliation:
Unit of Psychiatry, IRCCS Istituto Centro San Giovanni di Dio-Fatebenefratelli, via Pilastroni 4, 25125Brescia, Italy
S. Bignotti
Affiliation:
Unit of Psychiatry, IRCCS Istituto Centro San Giovanni di Dio-Fatebenefratelli, via Pilastroni 4, 25125Brescia, Italy
L.R. Magni
Affiliation:
Unit of Psychiatry, IRCCS Istituto Centro San Giovanni di Dio-Fatebenefratelli, via Pilastroni 4, 25125Brescia, Italy
L. Rillosi
Affiliation:
Unit of Psychiatry, IRCCS Istituto Centro San Giovanni di Dio-Fatebenefratelli, via Pilastroni 4, 25125Brescia, Italy
S. Magnaldi
Affiliation:
Unit of Neuroradiology, Poliambulanza Hospital, Brescia, Italy
M. Cobelli
Affiliation:
Unit of Neuroradiology, Poliambulanza Hospital, Brescia, Italy
G. Rossi
Affiliation:
Unit of Psychiatry, IRCCS Istituto Centro San Giovanni di Dio-Fatebenefratelli, via Pilastroni 4, 25125Brescia, Italy
G.B. Frisoni
Affiliation:
LENITEM, Laboratory of Epidemiology, Neuroimaging, & Telemedicine, Istituto Centro San Giovanni di Dio-Fatebenefratelli, Brescia, Italy Memory Clinic and LANVIE, Laboratory of Neuroimaging of Aging, University Hospitals, University of Geneva, Geneva, Switzerland
*
*Corresponding author. Tel.: +39 030 35017719; fax: +39 030 3501592. E-mail address:[email protected] (R. Rossi).
Get access

Abstract

Background:

Borderline personality disorder (BPD) is a chronic condition with a strong impact on patients’ affective, cognitive and social functioning. Neuroimaging techniques offer invaluable tools to understand the biological substrate of the disease. We aimed to investigate gray matter alterations over the whole cortex in a group of Borderline Personality Disorder (BPD) patients compared to healthy controls (HC).

Methods:

Magnetic resonance-based cortical pattern matching was used to assess cortical gray matter density (GMD) in 26 BPD patients and in their age- and sex-matched HC (age: 38 ± 11; females: 16, 61%).

Results:

BPD patients showed widespread lower cortical GMD compared to HC (4% difference) with peaks of lower density located in the dorsal frontal cortex, in the orbitofrontal cortex, the anterior and posterior cingulate, the right parietal lobe, the temporal lobe (medial temporal cortex and fusiform gyrus) and in the visual cortex (P < 0.005). Our BPD subjects displayed a symmetric distribution of anomalies in the dorsal aspect of the cortical mantle, but a wider involvement of the left hemisphere in the mesial aspect in terms of lower density. A few restricted regions of higher density were detected in the right hemisphere. All regions remained significant after correction for multiple comparisons via permutation testing.

Conclusions:

BPD patients feature specific morphology of the cerebral structures involved in cognitive and emotional processing and social cognition/mentalization, consistent with clinical and functional data.

Keywords

Borderline personality disorderNeuroimagingMRI
Type
Original article
Information
European Psychiatry , Volume 30 , Issue 2 , February 2015 , pp. 221 - 227
Copyright
Copyright © Elsevier Masson SAS 2014

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Adolphs, R., Spezio, M.. Role of the amygdala in processing visual social stimuli. Prog Brain Res 2006; 156 2: 363–378.CrossRefGoogle ScholarPubMed
Allison, T., Puce, A., McCarthy, G.. Social perception from visual cues: role of the STS region. Trends Cogn Sci 2000; 4 2: 267–278.CrossRefGoogle ScholarPubMed
Bagby, R.M., Taylor, G.J., Parker, J.D.. The Twenty-item Toronto Alexithymia Scale--II. Convergent, discriminant, and concurrent validity. J Psychosom Res 1994; 38 2: 33–40.CrossRefGoogle ScholarPubMed
Bearden, C.E., Thompson, P.M., Dutton, R.A., et al.Three-dimensional mapping of hippocampal anatomy in unmedicated and lithium-treated patients with bipolar disorder. Neuropsychopharmacology 2008;33 :1229–1238.CrossRefGoogle ScholarPubMed
Beer, J.S., John, O.P., Scabini, D., Knight, R.T.. Orbitofrontal cortex and social behavior: integrating self-monitoring and emotion-cognition interactions. J Cogn Neurosci 2006;18 :871–879.CrossRefGoogle ScholarPubMed
Boccardi, M., Frisoni, G.B., Hare, R.D., Cavedo, E., et al.Cortex and amygdala morphology in psychopathy. Psychiatry Res 2011;193 :85–92.CrossRefGoogle ScholarPubMed
Bøen, E., Westlye, L.T., Elvsåshagen, T., et al.Regional cortical thinning may be a biological marker for borderline personality disorder. Acta Psychiatr Scand 2013. http://dx.doi.org/10.1111/acps.12234Google ScholarPubMed
Bokde, A.L., Lopez-Bayo, P., Meindl, T., Pechler, S., et al.Functional connectivity of the fusiform gyrus during a facematching task in subjects with mild cognitive impairment. Brain 2006;129 :1113–1124.CrossRefGoogle Scholar
Brambilla, P., Soloff, P.H., Sala, M., Nicoletti, M.A., et al.Anatomical MRI study of borderline personality disorder patients. Psychiatry Res 2004;131 :125–133.CrossRefGoogle ScholarPubMed
Braus, D.F., Ende, G., Weber-Fahr, W., Demirakca, T., Henn, F.A.. Favorable effect on neuronal viability in the anterior cingulate gyrus due to long-term treatment with atypical antipsychotics: an MRSI study. Pharmacopsychiatry 2001;34 :251–253.CrossRefGoogle Scholar
Brunner, R., Henze, R., Parzer, P., Kramer, J., et al.Reduced prefrontal and orbitofrontal gray matter in female adolescents with borderline personality disorder: is it disorder specific?. Neuroimage 2010;49 :114–120.CrossRefGoogle ScholarPubMed
Calarge, C, Andreasen, N.C., O’Leary, D.S.. Visualizing how one brain understands another: a PET study of theory of mind. Am J Psychiatry 2003;160 :1954–1964.CrossRefGoogle ScholarPubMed
Chanen, A.M., Velakoulis, D., Carison, K., Gaunson, K., Wood, S.J., Yuen, H.P., et al.Orbitofrontal, amygdala and hippocampal volumes in teenagers with first-presentation borderline personality disorder. Psychiatry Res 2008;163 :116–125.CrossRefGoogle ScholarPubMed
de Araujo Filho, G.M., Abdallah, C., Sato, J.R., et al.Morphometric hemispheric asymmetry of orbitofrontal cortex in women with borderline personality disorder: a multi-parameter approach. Psychiatry Res 2014;223 :61–66.CrossRefGoogle ScholarPubMed
de Araujo, T.B., de Araujo Filho, G.M., Sato, J.R., de Araújo, C.M., et al.Cortical morphology changes in women with borderline personality disorder: a multimodal approach. Rev Bras Psiquiatr 2014;36 :32–38.CrossRefGoogle Scholar
de Girolamo, G., Picardi, A., Micciolo, R., Falloon, I., et al.Residential care in Italy. National survey of non-hospital facilities. Br J Psychiat 2002;181 :220–225.CrossRefGoogle ScholarPubMed
First, M.B., Spitzer, R.L., Gibbon, J.B.W., Williams, M., Benjamin, L.Structured Clinical Interview for DSM-IV Axis II Personality Disorders (SCID-II). New York: New York State Psychiatric Institute, Biometric Research Department; 1994.Google Scholar
First, M.B., Spitzer, R.L., Gibbon, M., Williams, J.B.W.Structured Clinical Interview for DSM-IV Axis I Disorders–Patient Edition (SCID-I/P). New York: New York State Psychiatric Institute, Biometric Research Department; 1994.Google Scholar
Frisoni, G.B., Prestia, A., Adorni, A., et al.In vivo neuropathology of cortical changes in elderly persons with schizophrenia. Biol Psychiatry 2009;66 :578–585.CrossRefGoogle ScholarPubMed
Galluzzi, S., Testa, C., Boccardi, M., Bresciani, L., et al.The Italian Brain Normative Archive of structural MR scans: norms for medial temporal atrophy and white matter lesions. Aging Clin Exp Res 2009;21 :266–276.CrossRefGoogle ScholarPubMed
Germanà, C., Kempton, M.J., Sarnicola, A., et al.The effects of lithium and anticonvulsants on brain structure in bipolar disorder. Acta Psychiat Scand 2010;122 :481–487.CrossRefGoogle ScholarPubMed
Gigantesco, A., Vittorielli, M., Pioli, R., Falloon, I.R., Rossi, G., Morosini, P.. The VADO approach in psychiatric rehabilitation: a randomized controlled trial. Psychiat Ser 2006;57 :1778–1783.CrossRefGoogle ScholarPubMed
Goodman, M., Hazlett, E.A., Avedon, J.B., Siever, D.R., et al.Anterior cingulate volume reduction in adolescents with borderline personality disorder and co-morbid major depression. J Psychiatr Res 2011;45 :803–807.CrossRefGoogle ScholarPubMed
Hamilton, M.. A rating scale for depression. J Neurol Neurosurg Psychiatry 1960;23 :56–62.CrossRefGoogle ScholarPubMed
Hazlett, E.A., New, A.S., Newmark, R., Haznedar, M.M., et al.Reduced anterior and posterior cingulate gray matter in borderline personality disorder. Biol Psychiatry 2005;58 :614–623.CrossRefGoogle ScholarPubMed
Herpertz, S.C., Dietrich, T.M., Wenning, B., Krings, T., Erberich, S.G., Willmes, K., et al.Evidence of abnormal amygdala functioning in borderline personality disorder: a functional MRI study. Biol Psychiatry 2001;50 :292–298.CrossRefGoogle ScholarPubMed
Hibar, D.P., van Erp, T.G.M., Rasmussen, J., et al.Meta-analysis of structural brain differences in bipolar disorder: the ENIGMA-Bipolar Disorder Project. Seattle, WA: OHBM; 2013.Google Scholar
Hill, J., Pilkonis, P., Morse, J., Feske, U., et al.Social domain dysfunction and disorganization in borderline personality disorder. Psychol Med 2008;38 :135–146.CrossRefGoogle ScholarPubMed
Irle, E., Lange, C., Sachsse, U.. Reduced size and abnormal asymmetry of parietal cortex in women with borderline personality disorder. Biol Psychiatry 2005;57 :173–182.CrossRefGoogle ScholarPubMed
Irle, E., Lange, C., Weniger, G., Sachsse, U.. Size abnormalities of the superior parietal cortices are related to dissociation in borderline personality disorder. Psychiatry Res 2007;156 :139–149.CrossRefGoogle ScholarPubMed
Lenzenweger, M.F.. Current status of the scientific study of the personality disorders: an overview of epidemiological, longitudinal, experimental psychopathology, and neurobehavioral perspectives. J Am Psychoanal Assoc 2010;58 :741–778.CrossRefGoogle ScholarPubMed
MacDonald, D., Avis, D., Evans, A.. Multiple surface identification and matching in magnetic resonance imaging. Proc SPIE 1994;2359 :160–169.CrossRefGoogle Scholar
Meyer-Lindenberg, A., Tost, H.. Neural mechanisms of social risk for psychiatric disorders. Nat Neurosci 2012;15 :663–668.CrossRefGoogle ScholarPubMed
Mier, D., Lis, S., Esslinger, C., Sauer, C., et al.Neuronal correlates of social cognition in borderline personality disorder. Soc Cogn Affect Neurosci 2013;8 :531–537.CrossRefGoogle ScholarPubMed
Minzenberg, M.J., Fan, J., New, A.S., Tang, C.Y., Siever, L.J.. Frontolimbic structural changes in borderline personality disorder. J Psychiatr Res 2008;42 :727–733.CrossRefGoogle ScholarPubMed
Narr, KL, Bilder, R.M., Toga, A.W., Woods, R.P., et al.Mapping cortical thickness and gray matter concentration in first episode schizophrenia. Cereb Cortex 2005;15 :708–719.CrossRefGoogle ScholarPubMed
Patton, J.H., Stanford, M.S., Barratt, E.S.. Factor structure of the Barratt impulsiveness scale. J Clin Psychol 1995;51 :768–774.3.0.CO;2-1>CrossRefGoogle ScholarPubMed
Putnam, K.M., Silk, K.R.. Emotion dysregulation and the development of borderline personality disorder. Dev Psychopathol 2005;17 :899–925.CrossRefGoogle ScholarPubMed
Rasser, P.E., Johnston, P., Lagopoulos, J., Ward, P.B., et al.Functional MRI BOLD response to Tower of London performance of first-episode schizophrenia patients using cortical pattern matching. Neuroimage 2005;26 :941–951.CrossRefGoogle Scholar
Riello, R., Sabattoli, F., Beltramello, A., Bonetti, M., et al.Brain volumes in healthy adults aged 40 years and over: a voxel-based morphometry study. Aging Clin Exp Res 2005;17 :329–336.CrossRefGoogle ScholarPubMed
Rizzolatti, G., Craighero, L.. The mirror-neuron system. Annu Rev Neurosci 2004;27 :169–192.CrossRefGoogle ScholarPubMed
Roncone, R., Ventura, J., Impallomeni, M., Falloon, I.R., et al.Reliability of an Italian standardized and expanded Brief Psychiatric Rating Scale (BPRS 4.0) in raters with high vs. low clinical experience. Acta Psychiat Scand 1999;100 :229–236.CrossRefGoogle ScholarPubMed
Ross, E.D., Homan, R.W., Buck, R.. Differential hemispheric lateralization of primary and social emotions. Neuropsychiatry Neuropsychol Behav Neurol 1994;7 :1–19.Google Scholar
Rossi, R., Ge Girolamo, G.Epidemiologia del disturbo borderline di personalità e delle comorbilità in Asse I. In: Sanza, M., Asioli, F., Ferrannini, L., editors. Disturbo Borderline di Personalità: continuità e discontinuità nel trattamento Milan: Centro Scientifico Editore; 2010.Google Scholar
Rossi, R., Lanfredi, M., Pievani, M., Boccardi, M., Beneduce, R., Rillosi, L., et al.Volumetric and topographic differences in hippocampal subdivisions in borderline personality and bipolar disorders. Psychiatry Res 2012;203 :132–138.CrossRefGoogle ScholarPubMed
Rossi, R., Pievani, M., Lorenzi, M., Boccardi, M., et al.Structural brain features of borderline personality and bipolar disorders. Psychiatry Res 2013;213 :83–91.CrossRefGoogle ScholarPubMed
Rüsch, N., van Elst, L.T., Ludaescher, P., Wilke, M., et al.A voxel-based morphometric MRI study in female patients with borderline personality disorder. Neuroimage 2003;20 :385–392.CrossRefGoogle ScholarPubMed
Santarelli, L., Saxe, M., Gross, C., Surget, A., et al.Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 2003;301 :805–809.CrossRefGoogle ScholarPubMed
Schmahl, C.G., Vermetten, E., Elzinga, B.M., Douglas Bremner, J.. Magnetic resonance imaging of hippocampal and amygdala volume in women with childhood abuse and borderline personality disorder. Psychiatry Res 2003;122 :193–198.CrossRefGoogle ScholarPubMed
Sharp, C., Fonagy, P.Social cognition and attachment-related disorders. Sharp, C., Fonagy, P., Goodyer, I., Social Cognition and Developmental Psychopathology Oxford: Oxford University Press; 2008. p.269–302.CrossRefGoogle Scholar
Shattuck, D.W., Sandor-Leahy, S.R., Schaper, K.A., Rottenberg, D.A., Leahy, R.M.. Magnetic resonance image tissue classification using a partial volume model. Neuroimage 2001;13 :856–876.CrossRefGoogle ScholarPubMed
Skodol, A.E., Gunderson, J.G., Shea, M.T., McGlashan, T.H., et al.The Collaborative Longitudinal Personality Disorders Study (CLPS): overview and implications. J Pers Disord 2005;19 :487–504.CrossRefGoogle ScholarPubMed
Sowell, E.R., Thompson, P.M., Rex, D., Kornsand, D., et al.Mapping sulcal pattern asymmetry and local cortical surface gray matter distribution in vivo: maturation in perisylvian cortices. Cereb Cortex 2002;12 :17–26.CrossRefGoogle ScholarPubMed
Spielberger, C.D., Gorsuch, R.L., Lushene, P.R., Vagg, P.R., Jacobs, A.G.Manual for the State-Trait Anxiety Inventory (Form Y). Palo Alto: Consulting Psychologists Press, Inc; 1983.Google Scholar
Tebartz van Elst, L., Hesslinger, B., Thiel, T., et al.Frontolimbic brain abnormalities in patients with borderline personality disorder: a volumetric magnetic resonance imaging study. Biol Psychiatry 2003;54 :163–171.CrossRefGoogle ScholarPubMed
Thompson, P.M., Hayashi, K.M., de Zubicaray, G., Janke, A.L., et al.Dynamics of gray matter loss in Alzheimer's disease. J Neurosci 2003;23 :994–1005.CrossRefGoogle ScholarPubMed
Thompson, P.M., Hayashi, K.M., De Zubicaray, G.I., et al.Mapping hippocampal and ventricular change in Alzheimer disease. Neuroimage 2004;22 :1754–1766.CrossRefGoogle ScholarPubMed
Thompson, P.M., Woods, R.P., Mega, M.S., Toga, A.W.. Mathematical/computational challenges in creating deformable and probabilistic atlases of the human brain. Hum Brain Map 2000;9 :81–92.3.0.CO;2-8>CrossRefGoogle ScholarPubMed
Turner, J.A., Hibar, D.P., Rasmussen, J., et al.A Prospective Meta-Analysis of Subcortical Brain Volumes in Schizophrenia via the ENIGMA Consortium. Seattle, WA: OHBM; 2013.Google Scholar
van Erp, T.G.M., Hibar, D.P., Rasmussen, J., et al.A Large-Scale Meta-Analysis of Subcortical Brain Volume Abnormalities in Schizophrenia via the ENIGMA Consortium. Society for Biological Psychiatry (SOBP); 2013.Google Scholar
Van Leemput, K., Maes, F., Vandermeulen, D., Suetens, P.Automated model-based tissue classification of MR images of the brain. IEEE T Med Imaging 1999;18 :897–908.CrossRefGoogle ScholarPubMed
Van Leemput, K., Maes, F., Vandermeulen, D., Suetens, P.Automated model-based bias field correction of MR images of the brain. IEEE T Med Imaging 1999;18 :885–896.CrossRefGoogle ScholarPubMed
Weniger, G., Lange, C., Sachsse, U., Irle, E.Reduced amygdala and hippocampus size in trauma-exposed women with borderline personality disorder and without posttraumatic stress disorder. J Psychiatry Neurosci 2009;34 :383–388.Google ScholarPubMed
Zanarini, M.C., Frankenbur, F.R., Weingeroff, J.L., Reich, D.B., et al.The course of substance use disorders in patients with borderline personality disorder and Axis II comparison subjects: a 10-year follow-up study. Addiction 2011;106 :342–348.CrossRefGoogle ScholarPubMed
Zetzsche, T., Frodl, T., Preuss, U.W., Schmitt, G., et al.Amygdala volume and depressive symptomsin patients with borderline personality disorder. Biol Psychiat 2006;60 :302–310.CrossRefGoogle Scholar
Submit a response

Comments

No Comments have been published for this article.