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Abnormal lateralization in schizophrenia: empirical evidence for an integrated model

Published online by Cambridge University Press:  16 April 2020

N Karny  and
I Nachson
N Karny
Affiliation:
Ness Ziona Rehabilitation and Mental Health Center, Ness Ziona, affiliated with the Sacklar School of Medicine, Tel-Aviv
I Nachson*
Affiliation:
Department of Criminology, Bar-Ilan University, Ramat Gan, 52900Israel
*
*Correspondence.
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Summary

Cerebral deficits in schizophrenia have been associated either with left hemisphere dysfunction, or with impairment in interhemispheric transfer. To test the relative efficacy of the two hypotheses, 63 right-handed subjects (24 paranoid schizophrenics, 21 nonparanoid schizophrenics, and 18 normal controls) were given two auditory lateral tasks: identification of dichotically delivered tonal sequences and digit sets. As the data analyses showed, more correct responses were given by the normal controls than by the patients, and by males than by females. Generally, report (especially from the ear reported second) was better from the right than from the left ear. This right ear advantage (which was more consistent in males than in females) was abnormally large for the paranoid schizophrenics who showed on both tests, relative to normal subjects, a slight decrement in right ear report and a significant decrement in left ear report. The data were interpreted as indicating left hemisphere dysfunction and structural callosal damage in paranoid schizophrenics.

Keywords

abnormal lateralizationschizophreniadichotic listening
Type
Original article
Information
European Psychiatry , Volume 10 , Issue 2 , 1995 , pp. 75 - 84
Copyright
Copyright © Elsevier, Paris 1995

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Footnotes

This study is based on a thesis submitted by Dr N Karny in partial fulfillment of the requirements towards an MA degree in psychiatry at the School for Continuous Studies, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv University, Part of this study was conducted while Dr I Nachson was a fellow at the Institute for Advanced Studies, the hebrew University, Jerusalem, and it was completed while he was a visiting professor in the Department of Psychology, the University of Toronto, Canada.

References

Aharonovich, EKarny, NNachson, IVisual field processing in paranoid and non-paranoid schizophrenics. Eur Psychiatry 1993; 8: 301–7CrossRefGoogle Scholar
Altman, JABalonov, LJDeglin, VLEffects of unilateral disorder of the brain hemisphere function in man on directional hearing. Neuropsychologia 1979;17:295–301CrossRefGoogle Scholar
American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders (3rd edition, revised). Washington, DC,1987Google Scholar
Bakker, DJSchroots, JFTemporal order in normal and disturbed children. In: Pavlidis, GTMiles, TR eds. Dyslexia Research and its Implications to Education. New York: Wiley, 1981; 87–98Google Scholar
Baldessarini, RJChemotherapy in Psychiatry. Cambridge: Harvard University Press, 1985Google Scholar
Beaumont, JGDimond, SJBrain disconnection and schizophrenia. Br J Psychiatry 1973; 123: 661–2CrossRefGoogle Scholar
Bigelow, LBNasrallah, HARauscher, PPCorpus callosum thickness in chronic schizophrenia. Br J Psychiatry 1983; 142: 284–7CrossRefGoogle ScholarPubMed
Blumstein, SGoodglass, HTarter, JThe reliability of ear advantage in dichotic listening. Brain Lang 1975; 2: 226–36CrossRefGoogle ScholarPubMed
Bruder, GECerebral laterality and psychopathology: a review of dichotic listening studies. Schizophrenia Bull 1983; 9: 134–51CrossRefGoogle ScholarPubMed
Bruder, GEDichotic listening in psychiatric patients. In: Hugdahl, K eds. Handbook of Dichotic Listening: Theory, Methods and Research 1988; 527–64Google Scholar
Bryden, MPEvidence for sex-related differences in cerebral organization. In: Wittig, MPeterson, AC eds. Sex-Related Differences in Cognitive Functioning. New York: Academic Press, 1979; 121–43Google Scholar
Bryden, MPLaterality: Functional Asymmetry in the Intact Brain. New York: Academic Press, 1982Google Scholar
Bull, HCVenables, PHSpeech perception in schizophrenia. Br J Psychiatry 1974; 125: 350–4CrossRefGoogle Scholar
Carmon, ANachshon, IEffect of unilateral brain damage on perception of temporal order. Cortex 1971; 7: 410–8CrossRefGoogle ScholarPubMed
Carr, SAInterhemispheric transfer of stereognostic information in chronic schizophrenia. Br J Psychiatry 1980; 136: 53–8CrossRefGoogle Scholar
Cutting, JThe Right Cerebral Hemisphere and Psychiatric Disorders. Oxford: Oxford University Press, 1990Google Scholar
Caudrey, DJKirk, KThe perception of speech in schizophrenia and affective disorders. In: Gruzelier, JFlor-Henry, P eds. Hemisphere Asymmetries of Function in Psychopathology. Amsterdam: Elsevier, 1979; 581–602Google Scholar
Clooney, JLMurray, DJSame-different judgments in paranoid and schizophrenic patients: a laterality study. J Abnorm Psychol 1977; 86: 655–8CrossRefGoogle ScholarPubMed
Colbourn, CJLishman, WALateralization of function and psychotic illness: a left hemisphere deficit. In: Gruzelier, JFlor-Henry, P eds. Hemisphere Asymmetries of Function in Psychopathology. Amsterdam: Elsevier, 1979; 539–60Google Scholar
Connoly, JFGruzelier, JHKleinman, KMHirsch, SRLateralized abnormalities in hemisphere-specific tachistoscopic tasks in psychiatric patients and controls. In: Gruzelier, JHFlor-Henry, P eds. Hemisphere Asymmetry of Function in Psychopathology. Amsterdam: Elsevier, 1979; 491–510Google Scholar
Connoly, JFGruzelier, JHManchanda, RElectrocortical and perceptual asymmetries in schizophrenia. In: Flor-Henry, PGruzelier, JH eds. Laterality and Psychopathology. Amsterdam: Elsevier, 1983; 363–78Google Scholar
Coren, SPorac, CDuncan, PA behaviorally validated selfreport inventory to assess four types of lateral preference. J Clin Neuropsychol 1979; 1: 55–84CrossRefGoogle Scholar
Damasio, HDamasio, ARCastro-Caldas, AFerro, JMDichotic listening pattern in relation to interhemispheric disconnexion. Neuropsychologia 1976; 14: 247–50CrossRefGoogle ScholarPubMed
David, ASTachistoscopic tests of colour naming and matching in schizophrenia: evidence for posterior callosum dysfunction?. Psychol Med 1987; 17: 621–30CrossRefGoogle ScholarPubMed
David, ASCallosal transfer in schizophrenia: too much or too little?. J Abnorm Psychol 1993; 102: 573–9CrossRefGoogle ScholarPubMed
Dimond, SDisconnection and psychopathology. In: Gruzelier, JFlor-Henry, P eds. Hemisphere Asymmetries of Function in Psychopathology. Amsterdam: Elsevier, 1979; 35–46Google Scholar
Dimond, SJScammel, REPryce, IGHuws, DGray, CCallosal transfer and left-hand anomia in schizophrenia. Biol Psychiatry 1979; 14: 735–9Google Scholar
Dimond, SJScammel, REPryce, IGHuws, DGray, CSome failure of intermanual and cross-lateral transfer in chronic schizophrenia. J Abnorm Psychol 1980; 89: 505–9CrossRefGoogle Scholar
Eaton, EMBush, JKMaloney, MPSloane, RBWipple, KWhite, KHemispheric dysfunction in schizophrenia: assessment by visual perception tasks. Psychiatr Res 1979; l: 315–32Google Scholar
Efron, RTemporal perception, aphasia, and Deja Vu. Brain 1963; 86: 403–24CrossRefGoogle Scholar
Flor-Henry, PCerebral Basis of Psychopathology. Boston: Wright, 1983Google Scholar
Flor-Henry, PKoles, ZJEEG studies in depression, mania and normals: evidence for partial shifts of laterality in the affective psychoses. Adv Biol Psychiatry 1980; 4: 21–43CrossRefGoogle Scholar
Flor-Henry, PGruzelier, J eds. Laterality and Psychopathology. Amsterdam: Elsevier, 1983Google Scholar
Goldman, PSLodge, AHammer, LRSemmes, JMishkin, MCritical flicker frequency after unilateral temporal lobectomy in man. Neuropsychologia 1968; 6: 355–63CrossRefGoogle Scholar
Gordon, HWCerebral organization in bilinguals. Brain Lang 1980; 9: 255–68CrossRefGoogle ScholarPubMed
Green, PDefective interhemispheric transfer and schizophrenia. J Abnorm Psychol 1978; 87: 472–80Google Scholar
Green, PGlass, AO'Callaghan, MSome implications of abnormal hemisphere interaction in schizophrenia. In: Gruzelier, JFlor-Henry, P eds. Hemisphere Asymmetries of Function in Psychopathology. Amsterdam: Elsevier, 1979; 431–48Google Scholar
Green, MWalker, EAttentional performance in positive and negative-symptom schizophrenia. J Nerv Ment Dis 1986; 174: 208–13CrossRefGoogle ScholarPubMed
Gruzelier, JHBimodal states of arousal and lateralized dysfunction in schizophrenia: effects of chlorpromazine. In: Wynne, LCCromwell, RLMatthysse, S eds. The Nature of Schizophrenia: New Approaches to Treatment. New York: Wiley, 1978; 167–83Google Scholar
Gruzelier, JHTheories of lateralized and interhemispheric dysfunction in syndromes of schizophrenia. In: Burrows, GDRubenstein, NG eds. Handbook of Studies in Schizophrenia. Amsterdam: Elsevier, 1986; 175–96Google Scholar
Gruzelier, JHHammond, NVSchizophrenia: a dominant hemisphere temporal-limbic disorder?. Res Commun Psychol Psychiatr Behav 1976; 1: 33–72Google Scholar
Gruzelier, JHHammond, NVThe effect of chlorpromazine upon bilateral asymmetries in biolectrical skin reactivity of schizophrenics. Studio Psychologica 1977; 19: 40–51Google Scholar
Gruzelier, JHHammond, NVThe effect of chlorpromazine upon psychophysiological endocrine and information pro-cessing measures in schizophrenia. J Psychiatr Res 1978; 14: 167–82CrossRefGoogle Scholar
Gruzelier, JFlor-Henry, P eds. Hemisphere Asymmetries of Function in Psychopathology. Amsterdam: Elsevier, 1979Google Scholar
Gruzelier, JHHammond, NVLateralized deficits and drug influences on the dichotic listening of schizophrenic patients. Biol Psychiatry 1980; 15: 759–79Google ScholarPubMed
Gulman, NCWildschiodtz, GOrbaek, KAlteration of interhemispheric conduction through corpus callosum in chronic schizophrenia. Biol Psychiatry 1982; 17: 585–94Google Scholar
Gur, REMotoric laterality imbalance in schizophrenics: a possible concomitant of left hemisphere dysfunction. Arch Gen Psychiatry 1977; 34: 33–7CrossRefGoogle ScholarPubMed
Gur, RELeft hemisphere dysfunction and left hemisphere overactivation in schizophrenia. J Abnorm Psychol 1978; 87: 226–38CrossRefGoogle Scholar
Gur, RECognitive concomitants of hemispheric dysfunction in schizophrenia. Arch Gen Psychiatry 1979; 36: 269–74CrossRefGoogle Scholar
Gur, REHemispheric overactivation in schizophrenia. In: Gruzelier, JFlor-Henry, P eds. Hemisphere Asymmetries of Function in Psychopathology. Amsterdam: Elsevier, 1979; 113–24Google Scholar
Hallen, SQuinn, DHewitt, JDefective interhemispheric integration and anomalous language lateralization in children at risk for schizophrenia. J Nerv Ment Dis 1986; 174: 418–27Google Scholar
Halperin, YNachshon, ICarmon, AShift of ear superiority in dichotic listening to temporally patterned nonverbal stimuli. J Acoust Soc Am 1973; 53: 46–50CrossRefGoogle ScholarPubMed
Hammond, NVGruzelier, JHLaterality, attention, and rate effects in the auditory temporal discrimination of chronic schizophrenics: the effect of treatment with chlorpromazine. Q J Exp Psychol 1978; 30: 91–103CrossRefGoogle ScholarPubMed
Hatta, TAyetani, NYoshizaki, KDichotic listening by chronic schizophrenic patients. Intern J Neurosci 1984; 23: 75–80CrossRefGoogle ScholarPubMed
Hatta, TYamamoto, MKawabata, YFunctional hemispheric differences in schizophrenia: interhemispheric transfer defi-cit or selective hemisphere dysfunction?. Biol Psychiatry 1984; 19: 1027–36Google ScholarPubMed
Hiramatsu, KIKameyama, TSaitoh, ONiwa, SICorrelations of event related potentials with schizophrenic deficits in information processing and hemisphere dysfunction. Biol Psychol 1984; 19: 281–94CrossRefGoogle Scholar
Hugdahl, K eds. Handbook of Dichotic Listening: Theory Methods Research. Sussex, England: Wiley, 1988Google Scholar
Ingvar, DHFunctional landscapes of the dominant hemisphere. Brain Res 1986; 107: 181–97CrossRefGoogle Scholar
Johnson, OCrockett, DChanges in perceptual asymmetries with clinical improvement of depression and schizophrenia. J Abnorm Psychol 1982; 91: 45–54Google Scholar
Kimura, DCerebral dominance and the perception of verbal stimuli. Can J Psychol 1961; 15: 166–71CrossRefGoogle Scholar
Kimura, DSome effects of temporal lobe damage on auditory perception. Can J Psychol 1961; 15: 156–65CrossRefGoogle ScholarPubMed
Kimura, DLeft-right differences in the perception of melodies. Q J Psychol 1964; 16: 355–8Google Scholar
Kimura, DAre men's and women's brains really different?. Can Psychol 1987; 28: 133–47Google Scholar
Kinsbourne, MThe normal and deviant development of functional lateralization of the brain. In: Müssen, PHHaith, MMCampos, JJ eds. Infancy and Developmental Psychology4th edHandbook of Clinical PsychologyVol 2.New York: Wiley, 1983; 158–280Google Scholar
Kraft, RHRelationship of ear specialization to degree of task difficulty, sex, and lateral preference. Percept Mot Skills 1982; 54: 703–14CrossRefGoogle ScholarPubMed
Kugler, BTAuditory processing in schizophrenic patients. In: Flor-Henry, PGruzelier, J eds. Laterally and Psychopathology. Amsterdam: Elsevier, 1983; 471–506Google Scholar
Lerner, JNachshon, JCarmon, AResponses of paranoid and nonparanoid schizophrenics on a dichotic listening task. J Nerv Ment Dis 1977; 164: 247–52CrossRefGoogle ScholarPubMed
Lishman, WAToone, BKColbourn, CJMcMeekan, ERLMance, RMDichotic listening in psychotic patients. Br J Psychiatry 1978; 132: 333–41CrossRefGoogle ScholarPubMed
Magaro, PACognition in schizophrenia and paranoia: the integration of cognitive processes. Hillsdale, NJ: Erlbaum, 1980Google Scholar
Magaro, PAThe paranoid and the schizophrenic: the case for distinctive cognitive style. Schizophr Bull 1981; 7: 632–61CrossRefGoogle ScholarPubMed
Magaro, PAChamrad, DLInformation processing and lateralization in schizophrenia. Biol Psychiatry 1983; 18: 29–44Google Scholar
Marin, RSTucker, GJPsychopathology and hemispheric dysfunction: a review. J Nerv Ment Dis 1981; 169: 546–57Google ScholarPubMed
McGlone, JThe neuropsychology of sex differences in human brain organization. In: Goldstein, GTarter, RE eds. Advances in Clinical Neuropsychologyvol 3 New York: Plenum, 1986; 1–30Google Scholar
Merrin, ELSchizophrenia and brain asymmetry: an evaluation of evidence for dominant lobe dysfunction. J Nerv Ment Dis 1981; 169: 405–16Google ScholarPubMed
Milner, BTaylor, LSperry, RWLateralized suppression of dichotically presented digits after commissural section in man. Science 1968; 161: 184–6CrossRefGoogle ScholarPubMed
Moscovitch, MInformation processing and cerebral hemispheres. In: Gazzaniga, MS eds. Handbook of Behavioral Biology vol 2 New York: Plenum, 1979; 379–446Google Scholar
Myslobodsky, MSMintz, MTomer, RNeuroleptic effects and the site of abnormality in schizophrenia. In: Myslobodsky, MS eds. Hemisyndromes: Psychobiology, Neurology, Psychiatry. New York: Academic Press, 1983; 347–88Google Scholar
Nachshon, IEffects of cerebral dominance and attention on dichotic listening. J Life Sci 1973; 3: 107–14Google ScholarPubMed
Nachshon, IHemispheric dysfunctioning in schizophrenia. J Nerv Ment Dis 1980; 168: 241–2CrossRefGoogle Scholar
Nachshon, ICross-cultural differences in laterality. Intern J Neurosci 1986; 30: 291–5CrossRefGoogle ScholarPubMed
Nachshon, ICross-language differences in dichotic listening. Intern J Psychology 1986; 21: 617–25CrossRefGoogle Scholar
Nachshon, IDichotic listening models of cerebral deficits in schizophrenia. In: Hugdahl, K eds. Handbook of Dichotic Listening: Theory, Methods and Research. Sussex, England: Wiley, 1988; 565–94Google Scholar
Nachshon, ICarmon, AEffect of stimulus-response delay on ear superiority for dichotically presented digits. J Exp Psychol 1973; 99: 288–90CrossRefGoogle ScholarPubMed
Nachson, IHarel, SDichotic listening to temporal stimuli by children with reading disabilities 1995(submitted for publication)Google Scholar
Nasrallah, HALaterality and hemisphere dysfunction in schizophrenia. In: Henns, FANasrallah, HA eds. Schizophrenia as a Brain Disease. New York: Oxford University Press, 1982; 273–94Google Scholar
Nasrallah, HAMcCalley-Whitters, MBigelow, LBRauscher, FPAHistological study of the corpus callosum in chronic schizophrenia. Psychiatr Res 1983; 8: 251–60CrossRefGoogle ScholarPubMed
Newlin, DBCarpenter, BGolden, CJHemispheric asymmetries in schizophrenia. Biol Psychiatry 1981; 16: 561–82Google Scholar
Raine, AAndrews, HSheard, CWalder, CManders, DInterhemispheric transfer in schizophrenics, depressives, and normals with schizoid tendencies. J Abnorm Psychol 1989; 98: 35–41CrossRefGoogle ScholarPubMed
Randall, PLA neuroanatomical theory on the etiology of schizophrenia. Medical Hypotheses 1967; 3: 645–58Google Scholar
Rosenthal, RBigelow, LBQuantitative brain measurement in chronic schizophrenia. Br J Psychiatry 1972; 121: 259–64CrossRefGoogle Scholar
Satz, PAchenbach, KPattishall, EFennell, EOrder of report, ear asymmetry and handedness in dichotic listening. Cortex 1965; 1: 377–96CrossRefGoogle Scholar
Schulhoff, CGoodglass, HDichotic listening, side of brain injury and cerebral dominance. Neuropsychologia 1969; 7: 149–60CrossRefGoogle Scholar
Schweitzer, LDifferences of cerebral lateralization among schizophrenic and depressed patients. Biol Psychiatry 1979; 14: 721–33Google ScholarPubMed
Schweitzer, LEvidence of right cerebral hemisphere dysfunction in schizophrenic patients with left hemisphere overactivation. Biol Psychiatry 1982; 17: 655–73Google ScholarPubMed
Schweitzer, LBecker, EWelsh, HAbnormalities of cerebral lateralization in schizophrenic patients. Arch Gen Psychiatry 1978; 35: 982–5CrossRefGoogle Scholar
Serafetinides, EALaterality and voltage in the EEG of psychiatric patients. Dis Nerv System 1972; 33: 622–3Google ScholarPubMed
Serafetinides, EAVoltage laterality in the EEG of psychiatric patients. Dis Nerv System 1973; 34: 190–1Google ScholarPubMed
Sparks, RGeschwind, NDichotic listening in man after section of neocortical commissures. Cortex 1968; 4: 3–16CrossRefGoogle Scholar
Springer, SPGazzaniga, MSDichotic testing of partial and complete split brain subjects. Neuropsychologia 1975; 13: 341–6CrossRefGoogle ScholarPubMed
Springer, SPSidtis, JWilson, DGazzaniga, MSLeft ear performance in dichotic listening following commissurotomy. Neuropsychologia 1978; 16: 305–12CrossRefGoogle ScholarPubMed
Stratta, PRossi, AGallucci, MAmicarelli, IPassariello, RCasacchia, MHemispheric asymmetries and schizophrenia: a preliminary magnetic resonance imaging study. Biol Psychiatry 1989; 25: 275–84CrossRefGoogle ScholarPubMed
Takahashi, RFlor-Henry, PGruzelier, JNiwa, SCerebral Dynamics, Laterality and Psychopathology. Amsterdam: Elsevier, 1987Google Scholar
Tanno, YMachiyama, YLeft hemisphere underactivation in schizophrenia: neuropsychological investigation by means of the letter-shape composite stimuli testTakahashi, RFlor-Henry, PGruzelier, JNiwa, SCerebral Dynamics, Laterally and Psychopathology Amsterdam: Elsevier, 1987; 331–2Google Scholar
Tomer, MAsymmetrical effects of neuroleptics on psychotic patients: performance of a tactile discrimination task. J Nerv Ment Dis 1989; 177: 699–700CrossRefGoogle ScholarPubMed
Tomer, MFlor-Henry, PNeuroleptic reverse attention asymmetries in schizophrenic patients. Biol Psychiatry 1989; 25: 852–60CrossRefGoogle ScholarPubMed
Tress, KHCaudrey, DJMehta, BTactile evoked potentials in schizophrenia: interhemispheric transfer and drug effects. Br J Psychiatry 1983; 143: 156–64CrossRefGoogle ScholarPubMed
Tucker, DMLateral brain function, emotion, and conceptualization. Psychol Bull 1981; 89: 19–46CrossRefGoogle ScholarPubMed
Walker, EHoppes, EEmory, EA reinterpretation of findings on hemispheric dysfunction in schizophrenia. J Nerv Ment Dis 1981; 169: 378–80Google Scholar
Walker, EMcGuire, MBilateral processing of visual and auditory stimuli by psychotic patients: a study of the nature and extent of performance asymmetries. Res Commun Psychol Psychiatr Behav 1982; 7: 441–61Google Scholar
Walker, EMcGuire, MIntra-and interhemisphere information processing in schizophrenia. Psychol Bull 1982; 92: 701–25CrossRefGoogle Scholar
Wexler, BEHeninger, GRAlterations in cerebral laterality during acute psychotic illness. Arch Gen Psychiatry 1979; 36: 278–84CrossRefGoogle ScholarPubMed
Yozawitz, ABruder, GSutton, SSharpe, LGurland, BFleiss, JCosta, LDichotic perception: evidence for right hemisphere dysfunction in affective psychosis. Br J Psychiatry 1979; 135:224–37Google ScholarPubMed
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