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749 – The Factors Associated with Occurrence of Suicidal Risk after Treatment of SSRI in Bipolar Disorder with their First Depressive Episode

Published online by Cambridge University Press:  15 April 2020

Z. Li ,
Y. Guan  and
Y. Fang
Z. Li
Affiliation:
Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University Division of Mood Disorders, Shanghai Mental Health Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Y. Guan
Affiliation:
Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University
Y. Fang
Affiliation:
Division of Mood Disorders, Shanghai Mental Health Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

Abstract

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Objective:

To explore the factors associated with occurrence of suicidal risk after treatment of Selective Serotonin Reuptake Inhibitor (SSRI) in bipolar disorder with their first depressive episode.

Methods:

One hundred and seventy seven bipolar patients were enrolled in this retrospective study. Demographic and clinic features between non-occurrence of suicidal risk group and occurrence of suicidal risk group were compared. Stepwise Logistic regression model was used to identify the associated factors. Concordance statistics (i.e. the area under the ROC curve) was used to compute the discrimination of the associated factors, and Hosmer-Lemeshow goodness-of-fit statistic was used to measure the goodness-of-fit.

Results:

One hundred and fifty four patients were included in non-occurrence of suicidal risk group, while twenty three were included in occurrence of suicidal risk group. Clinical features associated with occurrence of suicidal risk after treatment of SSRI in bipolar disorder were as follows: symptom of irritability (OR=4.04, 95 CI:1.40-11.67) and psychotic symptom (OR=6.23, 95 CI:1.40-27.56).

Conclusion:

This study demonstrated indicated that psychotic symptom and symptom of irritability were associated with occurrence of suicidal risk after treatment of SSRI in bipolar disorder, and it suggested that these two symptoms might be potential to be the predictors of occurrence of suicidal risk after treatment of SSRI in bipolar disorder.

Type
Abstract
Information
European Psychiatry , Volume 28 , Issue S1: Abstracts of the 21th European Congress of Psychiatry , 2013 , 28-E247
Copyright
Copyright © European Psychiatric Association 2013
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