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2959 – Maintaining Symptom Stability in the Long-Term Treatment of Bipolar I Disorder

Published online by Cambridge University Press:  15 April 2020

C. Correll
C. Correll*
Affiliation:
The Zucker Hillside Hospital, Glen Oaks, NY, USA

Abstract

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Following remission of an acute episode, patients with bipolar I disorder remain at a high risk for relapse, regardless of the nature of their index episode.1 in particular, if the medication regimen in the acute phase is different than that used in the maintenance phase, there may be a potential loss of efficacy or a change in adverse-event burden associated with the switch. Therefore, choosing the right pharmacotherapy is essential to allow patients to achieve and maintain stability, and prevent the recurrence of mood episodes.

Current clinical practice guidelines recommend combination therapy of atypical antipsychotics and lithium or valproate as firstline treatment in acute patients, or for maintenance treatment in patients with an inadequate response to monotherapy with mood stabilisers.2 Therefore, exploring the long-term benefits and risks of monotherapy compared with combination therapy are essential for improving patient outcomes in the course of routine clinical practice.3 Recent clinical trial evidence suggests that combination therapy is effective in patients with an inadequate response to monotherapy, and that there are relatively lowrisk options regarding adverse events and comorbid physical conditions that are frequently encountered in patients with bipolar I disorder.3

This presentation will explore how to manage patients with a partial response to pharmacotherapy or with persistent residual symptoms long term, and how to address the unmet needs of this patient population in the context of recent clinical trial evidence.

Type
Abstract
Information
European Psychiatry , Volume 28 , Issue S1: Abstracts of the 21th European Congress of Psychiatry , 2013 , 28-E1778
Copyright
Copyright © European Psychiatric Association 2013

References

References:

American Psychiatric AssociationPractice Guideline For The Treatment of Patients With Bipolar Disorder (revision). Am J Psychiatry 1594 Suppl2002 150Google Scholar
Carlson, B.X., et al.Aripiprazole in Combination With Lamotrigine For The Long-term Treatment of Patients With Bipolar i Disorder (manic Or Mixed): a Randomized, Multicenter, Double-blind Study (cn138-392). Bipolar Disord 2002; 14: 41–53CrossRefGoogle Scholar
Marcus, R., et al.Efficacy of Aripiprazole Adjunctive To Lithium Or Valproate in The Long-term Treatment of Patients With Bipolar i Disorder With An Inadequate Response To Lithium Or Valproate Monotherapy: a Multicenter, Double-blind, Randomized Study. Bipolar Disord 2011; 13: 133–144CrossRefGoogle Scholar
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