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269 – Increase of Beta-endorphin Plasma Level as a Potential Marker of Positive Response to Treatment of Depression

Published online by Cambridge University Press:  15 April 2020

O. Kubryak  and
I. Emelyanova
O. Kubryak
Affiliation:
Research Institute of Normal Physiology named by P.K. Anokhin, Russian Academy of Medical Science
I. Emelyanova
Affiliation:
Moscow Research Institute of Psychiatry, Moscow, Russia

Abstract

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Introduction:

There are new materials in looking for objective tools of mental conditions of depression patients. Grant of Russian humanitarian scientific fund: 11-06-00869.

Objectives:

21 patient (7 male; 14 female; mean age - 38.2 years).

Aims:

Assessment of beta-endorphin concentration in peripheral blood in patients with mild and moderate unipolar depression. Implementation of this parameter as a marker of treatment efficacy.

Methods:

Ethically approved prospective study; HDRS; ELISA; statistical analysis

Results:

Changes in beta-endorphin level appeared to be more significant marker than peptides‘ absolute level. Degree of beta-endorphin changes and degree of HDRS score changes were significantly correlated (p = 0.009; Spearman correlation coefficient ρ = - 0.6). Individual change was calculated as ratio of previous value divided by subsequent value. Therefore, higher increase of beta-endorphin concentration was associated with higher decrease in HDRS score. Figure.

[Figure]

A0 - mean HDRS sample score (n=21); A1 - mean HDRS score in patients with beta-endorphin decrease (n=6); A2 - mean HDRS score in patients with beta-endorphin increase (n=15).

Conclusion:

Preliminary data show that increase in beta-endorphin plasma level in patients with non-psychotic unipolar depression after 2 weeks of treatment is associated with positive response to treatment.

Type
Abstract
Information
European Psychiatry , Volume 28 , Issue S1: Abstracts of the 21th European Congress of Psychiatry , 2013 , 28-E2
Copyright
Copyright © European Psychiatric Association 2013
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