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2629 – Impaired Emotional Processing is Reflected in Long Latency Event Related Potentials During Visual Emotional Stimulation in Post-Traumatic Patients

Published online by Cambridge University Press:  15 April 2020

H. Shalev ,
R. Saar ,
J. Guez ,
A. Friedman ,
A. Shiber  and
J. Cohen
H. Shalev
Affiliation:
Psychiatry, Soroka University Medical Center Zlotowski Center for Neuroscience, Ben-Gurion University, Beer-Sheva
R. Saar
Affiliation:
Zlotowski Center for Neuroscience, Ben-Gurion University, Beer-Sheva
J. Guez
Affiliation:
Psychiatry, Soroka University Medical Center
A. Friedman
Affiliation:
Zlotowski Center for Neuroscience, Ben-Gurion University, Beer-Sheva
A. Shiber
Affiliation:
Psychiatry, Soroka University Medical Center
J. Cohen
Affiliation:
Zlotowski Center for Neuroscience, Ben-Gurion University, Beer-Sheva Sharett Institute of Oncology, Hadassah Medical Organization, Jerusalem, Israel

Abstract

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Introduction:

PTSD patients display abnormal emotional processing and bias towards negative emotion. Long latency eventrelated potentials (ERP’s) are composed of the P300 and subsequent slow wave activity. These ERP’s are hypothesized to be relevant for attentional and initial memory storage events as well as emotional processing. objectives: This study tested the hypothesis that abnormal emotional processing in PTSD is reflected in altered brain activity, as measured via ERP’s.

Aims:

Detect differences in cortical activity and emotional processing in PTSD patients as compared to controls.

Methods:

ERP’s were recorded from 14 PTSD and 14 control subjects while viewing emotion-laden pictures. Subjects were instructed to press a button depending on the presence of a person or human part in the picture and response time was recorded.

Results:

Long latency ERP data (300-1035 msec) showed valence dependent activity in control subjects distinguishing negative vs. positive and neutral pictures. PTSD patients, however, lacked differential activation and had similar brain activity across all picture valances, which resembled the pattern observed in controls only for negative stimuli.

[Late ERP’s 980-1035msec]

PTSD patients also exhibited longer response time.

Conclusions:

Our results demonstrate abnormal cognitive-emotional processing in PTSD patients and may underlie overgeneralization processes that are part of this disorder.

Type
Abstract
Information
European Psychiatry , Volume 28 , Issue S1: Abstracts of the 21th European Congress of Psychiatry , 2013 , 28-E1557
Copyright
Copyright © European Psychiatric Association 2013
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