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2177 – Neuroanatomical Changes Associated With Subthreshold Depression In Adolescents

Published online by Cambridge University Press:  15 April 2020

H. Vulser ,
M.-L. Paillere-Martinot ,
H. Lemaitre ,
R. Miranda ,
E. Artiges ,
R. Goodman ,
J. Penttilä ,
M. Struve ,
T. Fadai  and
V. Kappel
...Show all authors
H. Vulser
Affiliation:
INSERM, UMR 1000, Research Unit Imaging and Psychiatry, University Paris-Sud, Université Paris Descartes, IFR49, CEA, DSV, I2BM-Service Hospitalier Frédéric Joliot, Orsay
M.-L. Paillere-Martinot
Affiliation:
INSERM, UMR 1000, Research Unit Imaging and Psychiatry, University Paris-Sud, Université Paris Descartes, IFR49, CEA, DSV, I2BM-Service Hospitalier Frédéric Joliot, Orsay AP-HP, Department of Adolescent Psychopathology and Medicine, Maison de Solenn, Cochin Hospital, Paris Université Paris Descartes, Sorbonne Paris Cité
H. Lemaitre
Affiliation:
INSERM, UMR 1000, Research Unit Imaging and Psychiatry, University Paris-Sud, Université Paris Descartes, IFR49, CEA, DSV, I2BM-Service Hospitalier Frédéric Joliot, Orsay Faculté de Médecine, Université Paris-Sud 11
R. Miranda
Affiliation:
INSERM, UMR 1000, Research Unit Imaging and Psychiatry, University Paris-Sud, Université Paris Descartes, IFR49, CEA, DSV, I2BM-Service Hospitalier Frédéric Joliot, Orsay
E. Artiges
Affiliation:
INSERM, UMR 1000, Research Unit Imaging and Psychiatry, University Paris-Sud, Université Paris Descartes, IFR49, CEA, DSV, I2BM-Service Hospitalier Frédéric Joliot, Orsay Faculté de Médecine, Université Paris-Sud 11 Psychiatry Department 91G16, Orsay Hospital, Orsay, France
R. Goodman
Affiliation:
Institute of Psychiatry, Kings College, London, UK
J. Penttilä
Affiliation:
Psychiatry Department, Päijät-Häme Central Hospital, Lahti, Finland
M. Struve
Affiliation:
Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim
T. Fadai
Affiliation:
Psychiatry, Universitaetsklinikum Hamburg Eppendorf, Hamburg
V. Kappel
Affiliation:
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Charité-Universitätsmedizin, Berlin
L. Poustka
Affiliation:
Psychiatry, Central Institute of Mental Health Mannheim, Mannheim, Germany
P. Conrod
Affiliation:
Department of Psychiatry, Universite de Montreal, CHU Ste Justine Hospital, Montreal, QC, Canada
T. Banaschewski
Affiliation:
Psychiatry, Central Institute of Mental Health Mannheim, Mannheim, Germany
A. Barbot
Affiliation:
I2BM-Neurospin, CEA, Gif-sur-Yvette, France
G.J. Barker
Affiliation:
Institute of Psychiatry, Kings College, London, UK
C. Büchel
Affiliation:
Psychiatry, Universitaetsklinikum Hamburg Eppendorf, Hamburg
H. Flor
Affiliation:
Psychology, Central Institute of Mental Health Mannheim, Mannheim
J. Gallinat
Affiliation:
Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité – Universitätsmedizin, Berlin, Germany
H. Garavan
Affiliation:
Psychology, Trinity College Institute of Neuroscience, Dublin, Ireland
A. Heinz
Affiliation:
Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité – Universitätsmedizin, Berlin, Germany
B. Ittermann
Affiliation:
Physikalisch-Technische Bundesanstalt (PTB) Braunschweig/Berlin, Berlin, Germany
C. Lawrence
Affiliation:
School of Psychology, University of Nottingham, Nottingham, UK
E. Loth
Affiliation:
Institute of Psychiatry, Kings College, London, UK
K. Mann
Affiliation:
Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim
T. Paus
Affiliation:
Psychology, Rotman Research Institute
Z. Pausova
Affiliation:
Department of Physiology and Nutritional Sciences, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
M. Rietschel
Affiliation:
Psychiatry, Central Institute of Mental Health Mannheim, Mannheim, Germany
T.W. Robbins
Affiliation:
Behavioural and Clinical Neurosciences Institute, Department of Experimental Psychology, University of Cambridge, Cambridge, UK
M. Smolka
Affiliation:
Department of Psychiatry and Psychotherapy, Technische Universität, Dresden, Germany
G. Schumann
Affiliation:
Institute of Psychiatry, Kings College, London, UK
J.-L. Martinot
Affiliation:
INSERM, UMR 1000, Research Unit Imaging and Psychiatry, University Paris-Sud, Université Paris Descartes, IFR49, CEA, DSV, I2BM-Service Hospitalier Frédéric Joliot, Orsay Faculté de Médecine, Université Paris-Sud 11 Université Paris Descartes, Sorbonne Paris Cité, Paris, France

Abstract

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Introduction

Although neuroimaging studies suggest brain regional abnormalities in depressive disorders, it remains unclear whether abnormalities are present at illness onset or reflect disease progression.

Objectives

We hypothesized that cerebral variations were present in adolescents with subthreshold depression known to be at high risk for later full-blown depression.

Aims

We examined brain structural and diffusion-weighted magnetic resonance images of adolescents with subthreshold depression.

Methods

The participants were extracted from the European IMAGEN study cohort of healthy adolescents recruited at age 14. Subthreshold depression was defined as a distinct period of abnormally depressed or irritable mood, or loss of interest, plus two or more depressive symptoms but without diagnosis of Major Depressive Episode. Comparisons were performed between adolescents meeting these criteria and control adolescents within the T1-weighted imaging modality (118 and 475 adolescents respectively) using voxel-based morphometry and the diffusion tensor imaging modality (89 ad 422 adolescents respectively) using tract-based spatial statistics. Whole brain analyses were performed with a statistical threshold set to p< 0.05 corrected for multiple comparisons.

Results

Compared with controls, adolescents with subthreshold depression had smaller gray matter volume in caudate nuclei, medial frontal and cingulate cortices; smaller white matter volume in anterior limb of internal capsules, left forceps minor and right cingulum; and lower fractional anisotropy and higher radial diffusivity in the genu of corpus callosum.

Conclusions

The findings suggest that adolescents with subthreshold depression have volumetric and microstructural gray and white matter changes in the emotion regulation frontal-striatal-limbic network.

Type
Abstract
Information
European Psychiatry , Volume 28 , Issue S1: Abstracts of the 21th European Congress of Psychiatry , 2013 , 28-E1340
Copyright
Copyright © European Psychiatric Association 2012
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