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2158 – Low Vascular Endothelial Growth Factor And Interleukin-8 In Cerebrospinal Fluid Of Suicide Attempters

Published online by Cambridge University Press:  15 April 2020

J. Isung ,
S. Aeinehband ,
F. Mobarrez ,
B. Mårtensson ,
P. Nordström ,
M. Åsberg ,
F. Piehl  and
J. Jokinen
J. Isung
Affiliation:
Department of Clinical Neuroscience, Stockholm, Sweden
S. Aeinehband
Affiliation:
Department of Clinical Neuroscience, Stockholm, Sweden
F. Mobarrez
Affiliation:
Department of Clinical Sciences, Karolinska Institutet (KI), Stockholm, Sweden
B. Mårtensson
Affiliation:
Department of Clinical Neuroscience, Stockholm, Sweden
P. Nordström
Affiliation:
Department of Clinical Neuroscience, Stockholm, Sweden
M. Åsberg
Affiliation:
Department of Clinical Sciences, Karolinska Institutet (KI), Stockholm, Sweden
F. Piehl
Affiliation:
Department of Clinical Neuroscience, Stockholm, Sweden
J. Jokinen
Affiliation:
Department of Clinical Neuroscience, Stockholm, Sweden

Abstract

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Immune system dysregulation influencing pathways for cytokine activity and growth factor expression is implicated in the pathophysiology of several neuropsychiatric disorders.

In this study we analysed cerebrospinal fluid (CSF) cytokines and growth factors with an ultra sensitive immunoassay system in 43 medication free suicide attempters and 20 healthy male volunteers.

CSF Vascular endothelial growth factor (VEGF) and CSF interleukin-8 (IL-8) levels were significantly lower in suicide attempters compared to healthy controls. Further, CSF VEGF showed a significant negative correlation with depression severity as measured with MADRS.

Low CSF levels of VEGF may represent a lack of trophic support to neurons and downregulation of neurogenesis in important areas such as the hippocampus reflecting more severe depressive states. IL-8 has also been reported as important in neuroprotection and is commonly known for its chemokine activity in the innate immune response.

The results support a role for a dysregulation in immune system activation in the pathophysiology of depression and suicidal behaviour. Innate immunity may have a critical role in these mechanisms.

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Abstract
Information
European Psychiatry , Volume 28 , Issue S1: Abstracts of the 21th European Congress of Psychiatry , 2013 , 28-E1327
Copyright
Copyright © European Psychiatric Association 2012
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