2040 – Clinical Characteristics Of Patients With Schizophrenia Associated With Drug And Alcohol Dependence

Abstract

Objective

To analyze social, demographic and clinical characteristics of patients with schizophrenia and comorbidity drug dependence.

Methods

Clinical interview with specially elaborated formalized card. Patients were diagnosed according to ICD-10 criteria. 182 patients were treated in St Petersburg state mental hospital № 3 in 2005-2010.

Results

Alcohol, cannabis, and heroin tend to be the primary substances of abuse. According to the drug usage we form two groups. The first group (n = 105, 57,7%) consisted of patients who abuse alcohol only. The second group consisted of patients who use different types of drugs (n = 77, 42,3%). Both groups had high rates of unemployment, disability, length of stay in a psychiatric hospital.

Schizophrenia patients with multidrug dependence (2^nd group) were younger than patients with alcohol dependence only (1^st group). Middle age of patients of 2^nd group was 31, 38 ± 0, 94 and middle age of patients of 1^st group was 42, 45 ± 1,14. Patients of both group were unemployed 92 (87, 61%) and 62 (80,52%) respectively.

We identified statistically significant between-group differences in patients with paranoid schizophrenia. Patients of 1^st group had paranoid schizophrenia higher 76 (72, 38%) than patients of 2^nd group 39 (50, 65%). On the contrary, simple schizophrenia was diagnosed more often in patients of 2^nd group 29, 87% and 14, 28% respectively.

Drug dependence disorders come before schizophrenia manifestation significantly more often (51,95%) than alcohol use disorders (AUD) (31,43%).

AUD occurred after schizophrenia manifestation (33, 33%) significantly more often than drug dependence disorders (12,9%).