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1972 – Imipramine Induced Acute Dystonia In a Child With Enuresis Nocturna: a Case Report

Published online by Cambridge University Press:  15 April 2020

M. Beyazyüz  and
Y. Albayrak
M. Beyazyüz
Affiliation:
Ankara Golbası Statel Hospital, Ankara
Y. Albayrak
Affiliation:
Psychiatry, Kırklareli State Hospital, Istanbul, Turkey

Abstract

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Introduction

Enuresis Nocturna has a very high prevalence in the preschool populationand the prevalence slowly reduces during childhood such that only 1-2% ofadults continue to experience the problem. Imipramine which is a tricyclic antidepressant is widely used in treatment of nocturnal enuresis (1).

Case

B. L. 8-year-old boy was assessed in our outpatient clinic and he had severe torticollis. In history, he had been diagnosed as enuresisnocturna by a child psychiatrist and had given imipramine 10 mg/day for treatment. After three days initiating imipramine 10 mg/day, he had severe muscular spasm on his neck. He had no psychiatric and neurological history.Physical examination, vital signs, serum chemistries, blood counts were withinnormal limits. Biperiden 5 mg administered intramusculary and after 45 minutestorticollis was resolved and he was refered to child psychiatry for the treatment of enuresis nocturna.

Discussion

In literature there are a few cases that are reporting imipramine induced dystonia.The mechanism of dystonia induced by imipramine is elusive but possibly involves complex interactions of dopamine, serotonin, acetylcholine and norepinephrine between cortical structures and basal ganglia (2). Since imipramine is administrated widely in child population; the prescribers should be aware of this rare side effect.

Type
Abstract
Information
European Psychiatry , Volume 28 , Issue S1: Abstracts of the 21th European Congress of Psychiatry , 2013 , 28-E1199
Copyright
Copyright © European Psychiatric Association 2013

References

Järvelin, M.R. Nocturanl Enuresis. Acta Paediatr 1999; 88: 589–591CrossRefGoogle Scholar
Gill, H.S., DeVane, C.L., Risch, S.C. Extrapyramidal Symptoms Associated With Cyclic Antidepressant Treatment: a Review Of Theliterature And Consolidating Hypotheses. J Clin Psychopharmacol 1997;17 5:377389.CrossRefGoogle Scholar
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