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1903 – Effect Of a Single Dose Of Methadone On Saccadic Refixations In Opioid Addicted Subjects With Hiv (+) And Hiv (-)

Published online by Cambridge University Press:  15 April 2020

J. Feit ,
E. Nowińska ,
K. Pasgreta ,
W. Lasoń ,
P. Walecki  and
E.J. Gorzelańczyk
J. Feit
Affiliation:
Department of Theoretical Basis of Bio-Medical Sciences and Medical Informatics, Collegium Medicum UMK Non-Public Health Care Center Sue Ryder Home, Bydgoszcz
E. Nowińska
Affiliation:
Department of Theoretical Basis of Bio-Medical Sciences and Medical Informatics, Collegium Medicum UMK
K. Pasgreta
Affiliation:
Department of Theoretical Basis of Bio-Medical Sciences and Medical Informatics, Collegium Medicum UMK
W. Lasoń
Affiliation:
Faculty of Medicine, Jagiellonian University, Medical College, Krakow
P. Walecki
Affiliation:
Faculty of Medicine, Jagiellonian University, Medical College, Krakow
E.J. Gorzelańczyk
Affiliation:
Department of Theoretical Basis of Bio-Medical Sciences and Medical Informatics, Collegium Medicum UMK Institute of Psychology, Polish Academy of Sciences, Warszawa Institute of Philosophy, Kazimierz Wielki University, Bydgoszcz, Poland

Abstract

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Introduction

Eye movements are closely related to cognitive and emotional functions. Information of saccadic dynamics during certain tasks may indicate disorders of mental functions that can help to explain the neurobiology of sensory-motor systems and be useful in neuropsychiatric diagnosis.

Aims/objectives

This study aims to assess the impact of a therapeutic dose of methadone on eye movements (saccades) in opioid addicted subjects with HIV(+) and HIV(-).

Methods

Sixty patients (29 patients with HIV(-) and 31 of HIV(+)) from the substitution program were examined. The examination was conducted twice: before and 1,5 hours after the administration of a therapeutic dose of methadone. Performed Latency Test (LT) with saccadometr diagnostic system.

Results

Mean duration of latency measured by LT Test after the administration of a therapeutic dose of methadone increases significantly in HIV(-) subjects but the mean peak velocity decrease in the study group. Mean peak velocity latency in HIV(+) subjects is not statistically significant. Mean duration and amplitude of latency after the administration of a therapeutic dose of methadone is a statistically significant in opioid addicted subjects with HIV(+). It was found that the mean peak velocity before the administration of a therapeutic dose of methadone was statistically significantly different in HIV(-) subjects as compared to HIV(+) ones.

Conclusion

The increase of saccadic refixation parameters values in opioid-addicted subjects after the administration of a therapeutic dose of methadone was observed.

Type
Abstract
Information
European Psychiatry , Volume 28 , Issue S1: Abstracts of the 21th European Congress of Psychiatry , 2013 , 28-E1142
Copyright
Copyright © European Psychiatric Association 2013
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